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Focal brainstem infarction in the adult rat / Ai Namioka in LabAnimal, 05/21 (May 2021 Vol. 21 N°5)
[article]
Titre : Focal brainstem infarction in the adult rat Type de document : texte imprimé Auteurs : Ai Namioka ; Takahiro Namiokai ; Masanori Sasak ; et al. Année de publication : 2021 Article en page(s) : p. 23-36 Note générale : DOI: 10.1038/s41684-021-00722-1 Langues : Anglais (eng) Mots-clés : Animals Brain Stem Infarctions Disease Models, Animal Female Humans Rats Rats, Sprague-Dawley Stroke Résumé : Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia are available, and they show great variability or cause early lethality. New, reliable animal models are therefore needed. By selectively ligating four points of the lower basilar artery, we developed a new focal basilar artery occlusion model that causes a localized brainstem ischemic lesion in female Sprague–Dawley rats. Analysis of ischemic lesion volume and neurological deficits over a period of 28 d showed that the rats present symptoms specific to this type of stroke while the ischemic lesion remains relatively unchanged over time. This procedure allows higher survival rates and extended observation periods compared with other models of brainstem ischemia. The procedure takes ~40 min, can be performed by researchers with basic surgical skills and does not require specialized surgical equipment. This protocol is highly reliable and will be useful to evaluate new therapeutic approaches to promote functional recovery in patients with brainstem ischemia. Permalink : ./index.php?lvl=notice_display&id=94504
in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 23-36[article] Focal brainstem infarction in the adult rat [texte imprimé] / Ai Namioka ; Takahiro Namiokai ; Masanori Sasak ; et al. . - 2021 . - p. 23-36.
DOI: 10.1038/s41684-021-00722-1
Langues : Anglais (eng)
in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 23-36
Mots-clés : Animals Brain Stem Infarctions Disease Models, Animal Female Humans Rats Rats, Sprague-Dawley Stroke Résumé : Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia are available, and they show great variability or cause early lethality. New, reliable animal models are therefore needed. By selectively ligating four points of the lower basilar artery, we developed a new focal basilar artery occlusion model that causes a localized brainstem ischemic lesion in female Sprague–Dawley rats. Analysis of ischemic lesion volume and neurological deficits over a period of 28 d showed that the rats present symptoms specific to this type of stroke while the ischemic lesion remains relatively unchanged over time. This procedure allows higher survival rates and extended observation periods compared with other models of brainstem ischemia. The procedure takes ~40 min, can be performed by researchers with basic surgical skills and does not require specialized surgical equipment. This protocol is highly reliable and will be useful to evaluate new therapeutic approaches to promote functional recovery in patients with brainstem ischemia. Permalink : ./index.php?lvl=notice_display&id=94504 Réservation
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DisponiblePercutaneous microembolization of the left coronary artery to model ischemic heart disease in rats / Allard Wagenaar in LabAnimal-Europe, 02/16 (février 2016)
[article]
Titre : Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats Type de document : texte imprimé Auteurs : Allard Wagenaar Année de publication : 2016 Article en page(s) : p. 29-37 Langues : Anglais (eng) Mots-clés : Animals Cardiac Catheterization Coronary Vessels/surgery Disease Models, Animal Embolism/complications Male Microspheres Myocardial Infarction/etiology Myocardial Ischemia*/etiology Polyethylene Rats, Sprague-Dawley Résumé : Abstract
Small animal models of myocardial infarction are used for a wide variety of research purposes, but common techniques for generating such models require thoracic surgeries that increase mortality risk and damage important structures, such as the pericardial sac. Here, we describe a technique for modeling myocardial infarction in rats by selective coronary microembolization, which has hitherto been described only in large animals. This technique selectively catheterizes the left coronary artery using a custom-made catheter that is introduced and precisely placed under fluoroscopic guidance. Microspheres are then injected through the catheter to cause embolization. This process creates multiple simultaneous micro-infarcts that resemble those from clinical embolization after a percutaneous coronary intervention. As this technique does not require thoracic surgery, a low attrition rate was expected and once it was optimized, this technique had a low mortality rate of just 14% during experimental application. This technique creates infarcts that appear small but are associated with transient ECG changes and a persistently lower ejection fraction after embolization. Microspheres are retained in the myocardial tissue and are visible by epifluorescent microscopy after histological staining and recognizable as a distinct speckle pattern in ultrasound images.Permalink : ./index.php?lvl=notice_display&id=66489
in LabAnimal-Europe > 02/16 (février 2016) . - p. 29-37[article] Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats [texte imprimé] / Allard Wagenaar . - 2016 . - p. 29-37.
Langues : Anglais (eng)
in LabAnimal-Europe > 02/16 (février 2016) . - p. 29-37
Mots-clés : Animals Cardiac Catheterization Coronary Vessels/surgery Disease Models, Animal Embolism/complications Male Microspheres Myocardial Infarction/etiology Myocardial Ischemia*/etiology Polyethylene Rats, Sprague-Dawley Résumé : Abstract
Small animal models of myocardial infarction are used for a wide variety of research purposes, but common techniques for generating such models require thoracic surgeries that increase mortality risk and damage important structures, such as the pericardial sac. Here, we describe a technique for modeling myocardial infarction in rats by selective coronary microembolization, which has hitherto been described only in large animals. This technique selectively catheterizes the left coronary artery using a custom-made catheter that is introduced and precisely placed under fluoroscopic guidance. Microspheres are then injected through the catheter to cause embolization. This process creates multiple simultaneous micro-infarcts that resemble those from clinical embolization after a percutaneous coronary intervention. As this technique does not require thoracic surgery, a low attrition rate was expected and once it was optimized, this technique had a low mortality rate of just 14% during experimental application. This technique creates infarcts that appear small but are associated with transient ECG changes and a persistently lower ejection fraction after embolization. Microspheres are retained in the myocardial tissue and are visible by epifluorescent microscopy after histological staining and recognizable as a distinct speckle pattern in ultrasound images.Permalink : ./index.php?lvl=notice_display&id=66489 Réservation
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