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Résultat de la recherche
3 résultat(s) recherche sur le mot-clé 'Immunogenicity'
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Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review / Laure Mathevon in Annals of physical and rehabilitation medicine, Vol. 62, n°4 (Juillet 2019)
[article]
Titre : Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review Type de document : texte imprimé Auteurs : Laure Mathevon ; Arnaud Declemy ; Isabelle Laffont ; Dominic Pérennou Année de publication : 2019 Article en page(s) : p. 241-251 Note générale : doi.org/10.1016/j.rehab.2019.03.004 Langues : Anglais (eng) Mots-clés : Limb spasticity Botulinum toxin Immunogenicity Resistance to treatment Neutralizing antibody Résumé : Background
The imputability of neutralizing antibodies (NABs) in secondary non-response (SnR) to botulinum toxin (BoNT) injections for limb spasticity is still debated.
Objective
This systematic literature review aimed to determine the prevalence of NABs after BoNT injections for limb spasticity and analyze their determinants and their causal role in SnR.
Methods
We searched MEDLINE via PubMed, Cochrane and Embase databases for articles published during 1990–2018. Two independent reviewers extracted the data and assessed the quality of studies with a specific scale (according to PRISMA and STROBE guidelines). Because the techniques used to detect NABs did not influence the results, we calculated the global (all studies) sensitivity and specificity of NAB positivity to reveal SnR.
Results
We included 14 articles published from 2002 to 2018 (including an epublication) describing 5 randomized controlled trials and 5 interventional and 4 observational studies. The quality was satisfactory (mean score 18/28 arbitrary units). NAB detection was the primary criterion in 5 studies and a secondary criterion in 9. In total, 1234 serum samples for 1234 participants (91% with stroke) were tested after injection. NAB prevalence was about 1%, with no significant difference among formulations. NAB positivity seemed favoured by long-duration therapy with high doses and a short interval between injections. The identification of non-response by NAB positivity had poor global sensitivity (56%) but very high specificity (99.6%). No consensual criteria were used to diagnose non-response to BoNT injection.
Conclusions
NAB prevalence is much lower after BoNT treatment for limb spasticity than cervical dystonia. Consensual criteria must be defined to diagnose non-response to BoNT injection. Because immunogenicity is not the most common cause of non-response to BoNT injection, NABs should be sought in individuals with SnR with no other cause explaining the treatment inefficacy. A test with 100% specificity is recommended. In cases for which immunogenicity is the most likely cause of non-response to BoNT injections, some biological arguments suggest trying another BoNT, but no clinical evidence supports this strategy.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065719300417 Permalink : ./index.php?lvl=notice_display&id=84129
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 241-251[article] Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review [texte imprimé] / Laure Mathevon ; Arnaud Declemy ; Isabelle Laffont ; Dominic Pérennou . - 2019 . - p. 241-251.
doi.org/10.1016/j.rehab.2019.03.004
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 241-251
Mots-clés : Limb spasticity Botulinum toxin Immunogenicity Resistance to treatment Neutralizing antibody Résumé : Background
The imputability of neutralizing antibodies (NABs) in secondary non-response (SnR) to botulinum toxin (BoNT) injections for limb spasticity is still debated.
Objective
This systematic literature review aimed to determine the prevalence of NABs after BoNT injections for limb spasticity and analyze their determinants and their causal role in SnR.
Methods
We searched MEDLINE via PubMed, Cochrane and Embase databases for articles published during 1990–2018. Two independent reviewers extracted the data and assessed the quality of studies with a specific scale (according to PRISMA and STROBE guidelines). Because the techniques used to detect NABs did not influence the results, we calculated the global (all studies) sensitivity and specificity of NAB positivity to reveal SnR.
Results
We included 14 articles published from 2002 to 2018 (including an epublication) describing 5 randomized controlled trials and 5 interventional and 4 observational studies. The quality was satisfactory (mean score 18/28 arbitrary units). NAB detection was the primary criterion in 5 studies and a secondary criterion in 9. In total, 1234 serum samples for 1234 participants (91% with stroke) were tested after injection. NAB prevalence was about 1%, with no significant difference among formulations. NAB positivity seemed favoured by long-duration therapy with high doses and a short interval between injections. The identification of non-response by NAB positivity had poor global sensitivity (56%) but very high specificity (99.6%). No consensual criteria were used to diagnose non-response to BoNT injection.
Conclusions
NAB prevalence is much lower after BoNT treatment for limb spasticity than cervical dystonia. Consensual criteria must be defined to diagnose non-response to BoNT injection. Because immunogenicity is not the most common cause of non-response to BoNT injection, NABs should be sought in individuals with SnR with no other cause explaining the treatment inefficacy. A test with 100% specificity is recommended. In cases for which immunogenicity is the most likely cause of non-response to BoNT injections, some biological arguments suggest trying another BoNT, but no clinical evidence supports this strategy.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065719300417 Permalink : ./index.php?lvl=notice_display&id=84129 Exemplaires (1)
Cote Support Localisation Section Disponibilité Revue Revue Centre de Documentation HELHa Campus Montignies Armoires à volets Document exclu du prêt - à consulter sur place
Exclu du prêtL'analyse biochimique en 10 étapes. Etape 1 : Les analyses biochimiques : éviter les erreurs (1) / Nicolas Soetart in Le Point vétérinaire Expert Canin, 404 (Avril 2020)
Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire Vaccination raisonnée du chat en 2020 / Séverine Boullier in Le Point vétérinaire Expert Canin, 404 (Avril 2020)
[article]
Titre : Vaccination raisonnée du chat en 2020 Type de document : texte imprimé Auteurs : Séverine Boullier ; Martin Monier Année de publication : 2020 Article en page(s) : P. 21-36 Langues : Français (fre) Mots-clés : pharmacovigilance vaccines serious adverse reactions hypersensitivity lack of efficacy cat Vaccines contagious diseases immunogenicity adjuvants Résumé : Lorsque les virus rusent et mutent, seule solution : la prévention, meilleure arme : la vaccination. Comme l’affirme avec génie Balzac, « la véritable puissance ne consiste pas à frapper fort, mais à frapper juste ». Les vaccins sont pensés sur ce fondement. Et les résultats sont spectaculaires : maladies éradiquées ou contrôlées, pandémies enrayées. Cela viendra pour le nouveau coronavirus humain. Heureusement.Les principales maladies contagieuses chez les chats bénéficient depuis longtemps de cette prévention. Mais son ampleur est insuffisante. La défiance actuelle impose même Note de contenu : VACCINATION : Les vaccins disponibles chez le chat
VACCINATION : Effets indésirables graves postvaccinaux chez le chat
Fiche de synthèsePermalink : ./index.php?lvl=notice_display&id=86010
in Le Point vétérinaire Expert Canin > 404 (Avril 2020) . - P. 21-36[article] Vaccination raisonnée du chat en 2020 [texte imprimé] / Séverine Boullier ; Martin Monier . - 2020 . - P. 21-36.
Langues : Français (fre)
in Le Point vétérinaire Expert Canin > 404 (Avril 2020) . - P. 21-36
Mots-clés : pharmacovigilance vaccines serious adverse reactions hypersensitivity lack of efficacy cat Vaccines contagious diseases immunogenicity adjuvants Résumé : Lorsque les virus rusent et mutent, seule solution : la prévention, meilleure arme : la vaccination. Comme l’affirme avec génie Balzac, « la véritable puissance ne consiste pas à frapper fort, mais à frapper juste ». Les vaccins sont pensés sur ce fondement. Et les résultats sont spectaculaires : maladies éradiquées ou contrôlées, pandémies enrayées. Cela viendra pour le nouveau coronavirus humain. Heureusement.Les principales maladies contagieuses chez les chats bénéficient depuis longtemps de cette prévention. Mais son ampleur est insuffisante. La défiance actuelle impose même Note de contenu : VACCINATION : Les vaccins disponibles chez le chat
VACCINATION : Effets indésirables graves postvaccinaux chez le chat
Fiche de synthèsePermalink : ./index.php?lvl=notice_display&id=86010 Exemplaires
Cote Support Localisation Section Disponibilité aucun exemplaire