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6 résultat(s) recherche sur le mot-clé 'Botulinum toxin'
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Role Of Motor End Plate-Targeted Botulinum Toxin Type A Injections In Children With Cerebral Palsy / Anja Van Campenhout in Acta Orthopaedica Belgica, Vol 81/2 (Juin 2015)
[article]
Titre : Role Of Motor End Plate-Targeted Botulinum Toxin Type A Injections In Children With Cerebral Palsy Type de document : texte imprimé Auteurs : Anja Van Campenhout, Auteur ; Lynn BAR-ON, Auteur ; Kaat Desloovere, Auteur Année de publication : 2015 Article en page(s) : p.167-171 Langues : Anglais (eng) Mots-clés : Botulinum toxin cerebral palsy motor end plate Résumé : Botulinum toxin type A (BTX) injections are frequently used in children with cerebral palsy (CP) to control spasticity. Injection variables still lead to variable outcomes of this treatment. Using instrumented spasticity assessment and muscle volume assessment the most effective location of the injection was demonstrated for gracilis and psoas muscles in children withCP. It was found that this treatment is most effectivewhen injected in the motor endplate zones of the selected muscles. This review article presents all available research on the role of motor endplate-targeting of BTX injections in children with CP. Permalink : ./index.php?lvl=notice_display&id=40531
in Acta Orthopaedica Belgica > Vol 81/2 (Juin 2015) . - p.167-171[article] Role Of Motor End Plate-Targeted Botulinum Toxin Type A Injections In Children With Cerebral Palsy [texte imprimé] / Anja Van Campenhout, Auteur ; Lynn BAR-ON, Auteur ; Kaat Desloovere, Auteur . - 2015 . - p.167-171.
Langues : Anglais (eng)
in Acta Orthopaedica Belgica > Vol 81/2 (Juin 2015) . - p.167-171
Mots-clés : Botulinum toxin cerebral palsy motor end plate Résumé : Botulinum toxin type A (BTX) injections are frequently used in children with cerebral palsy (CP) to control spasticity. Injection variables still lead to variable outcomes of this treatment. Using instrumented spasticity assessment and muscle volume assessment the most effective location of the injection was demonstrated for gracilis and psoas muscles in children withCP. It was found that this treatment is most effectivewhen injected in the motor endplate zones of the selected muscles. This review article presents all available research on the role of motor endplate-targeting of BTX injections in children with CP. Permalink : ./index.php?lvl=notice_display&id=40531 Exemplaires (1)
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Exclu du prêtAdjunct therapies to improve outcomes after botulinum toxin injection in children: A systematic review / L. Mathevon in Annals of physical and rehabilitation medicine, Vol. 62, n°4 (Juillet 2019)
[article]
Titre : Adjunct therapies to improve outcomes after botulinum toxin injection in children: A systematic review Type de document : texte imprimé Auteurs : L. Mathevon ; Isabelle V. Bonan ; J.-L. Barnais ; Mickael Dinomais Année de publication : 2019 Article en page(s) : p. 283-290 Note générale : doi.org/10.1016/j.rehab.2018.06.010 Langues : Anglais (eng) Mots-clés : Spasticity Cerebral palsy Botulinum toxin Casting Rehabilitation programme Résumé : Background
Botulinum toxin (BTX) injection alone is not sufficient to treat spasticity in children, notably those with cerebral palsy; thus, there is an emerging trend for adjunct therapies to offer greater outcomes than BTX alone.
Objective
The aim of this systematic review was to evaluate the general effectiveness of adjunct therapies regardless of their nature in children with spasticity.
Methods
Medline, Cochrane and Embase databases were searched from January 1980 to March 15, 2018 for reports of parallel-group trials (randomized controlled trials [RCTs] and non-RCTs) assessing adjunct therapies after BTX injection for treating spasticity in children. Two independent reviewers extracted data and assessed the risk of bias by using the PEDro scale for RCTs and Downs and Black scale (D&B) for non-RCTs.
Results
Overall, 20 articles involving 662 participants met the inclusion criteria. The average quality was good for the 16 RCTs (mean PEDro score 7.4 [SD 1.6]) and poor to moderate for the 4 non-RCTs (D&B score 9 to 17). Adjunct therapies consisted of casting/posture, electrical stimulation, resistance training and rehabilitation programmes. Casting associated with BTX injection improved the range of passive and active motion and reduced spasticity better than did BTX alone (9 studies), with a follow-up of 1 year. Resistance training enhanced the quality and performance of muscles without increasing spasticity. Only 3 rehabilitation programmes were studied, with encouraging results for activities.
Conclusion
Lower-limb posture with casting in children has a high level of evidence, but the long-term efficacy of short-leg casting needs to be evaluated. A comparison between the different modalities of casting is missing, and studies specifically devoted to testing the different kinds of casting are needed. Moreover, the delay to casting after BTX injection is not clear. Data on electrical stimulation are not conclusive. Despite the small number of studies, resistance training could be an interesting adjunct therapy notably to avoid loss of strength after BTX injection. Rehabilitation programmes after BTX injection still need to be evaluated.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065718314301 Permalink : ./index.php?lvl=notice_display&id=84133
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 283-290[article] Adjunct therapies to improve outcomes after botulinum toxin injection in children: A systematic review [texte imprimé] / L. Mathevon ; Isabelle V. Bonan ; J.-L. Barnais ; Mickael Dinomais . - 2019 . - p. 283-290.
doi.org/10.1016/j.rehab.2018.06.010
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 283-290
Mots-clés : Spasticity Cerebral palsy Botulinum toxin Casting Rehabilitation programme Résumé : Background
Botulinum toxin (BTX) injection alone is not sufficient to treat spasticity in children, notably those with cerebral palsy; thus, there is an emerging trend for adjunct therapies to offer greater outcomes than BTX alone.
Objective
The aim of this systematic review was to evaluate the general effectiveness of adjunct therapies regardless of their nature in children with spasticity.
Methods
Medline, Cochrane and Embase databases were searched from January 1980 to March 15, 2018 for reports of parallel-group trials (randomized controlled trials [RCTs] and non-RCTs) assessing adjunct therapies after BTX injection for treating spasticity in children. Two independent reviewers extracted data and assessed the risk of bias by using the PEDro scale for RCTs and Downs and Black scale (D&B) for non-RCTs.
Results
Overall, 20 articles involving 662 participants met the inclusion criteria. The average quality was good for the 16 RCTs (mean PEDro score 7.4 [SD 1.6]) and poor to moderate for the 4 non-RCTs (D&B score 9 to 17). Adjunct therapies consisted of casting/posture, electrical stimulation, resistance training and rehabilitation programmes. Casting associated with BTX injection improved the range of passive and active motion and reduced spasticity better than did BTX alone (9 studies), with a follow-up of 1 year. Resistance training enhanced the quality and performance of muscles without increasing spasticity. Only 3 rehabilitation programmes were studied, with encouraging results for activities.
Conclusion
Lower-limb posture with casting in children has a high level of evidence, but the long-term efficacy of short-leg casting needs to be evaluated. A comparison between the different modalities of casting is missing, and studies specifically devoted to testing the different kinds of casting are needed. Moreover, the delay to casting after BTX injection is not clear. Data on electrical stimulation are not conclusive. Despite the small number of studies, resistance training could be an interesting adjunct therapy notably to avoid loss of strength after BTX injection. Rehabilitation programmes after BTX injection still need to be evaluated.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065718314301 Permalink : ./index.php?lvl=notice_display&id=84133 Exemplaires (1)
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Exclu du prêtChronic exertional compartment syndrome in hands successfully treated with botulinum toxin-A: A case / Cyril Orta in Annals of physical and rehabilitation medicine, Vol. 61, n°3 (Mai 2018)
[article]
Titre : Chronic exertional compartment syndrome in hands successfully treated with botulinum toxin-A: A case Type de document : texte imprimé Auteurs : Cyril Orta ; Julien Petit ; Vincent Gremeaux Année de publication : 2018 Article en page(s) : p. 183-185 Langues : Anglais (eng) Mots-clés : Chronic exertional compartment syndrome Botulinum toxin Hand Evaluation Permalink : ./index.php?lvl=notice_display&id=80466
in Annals of physical and rehabilitation medicine > Vol. 61, n°3 (Mai 2018) . - p. 183-185[article] Chronic exertional compartment syndrome in hands successfully treated with botulinum toxin-A: A case [texte imprimé] / Cyril Orta ; Julien Petit ; Vincent Gremeaux . - 2018 . - p. 183-185.
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 61, n°3 (Mai 2018) . - p. 183-185
Mots-clés : Chronic exertional compartment syndrome Botulinum toxin Hand Evaluation Permalink : ./index.php?lvl=notice_display&id=80466 Exemplaires (1)
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Exclu du prêtDoes botulinum toxin treatment improve upper limb active function? / Jonathan Lévy in Annals of physical and rehabilitation medicine, Vol. 62, n°4 (Juillet 2019)
[article]
Titre : Does botulinum toxin treatment improve upper limb active function? Type de document : texte imprimé Auteurs : Jonathan Lévy Année de publication : 2019 Article en page(s) : p. 234-240 Note générale : https://doi.org/10.1016/j.rehab.2018.05.1320 Langues : Anglais (eng) Mots-clés : Spasticity Botulinum toxin Rehabilitation Outcome Upper limb Stroke Résumé : Background
Spasticity following lesions of the central nervous system such as stroke is a major cause of impairment and disability, especially when it affects the upper limb, and can be focally relieved by intramuscular injections of botulinum toxin (BT). Functional improvements of the affected upper limb after a BT focal treatment remain controversial.
Objective
We aimed to assess the functional effects of BT treatment on upper-limb spasticity in the literature, identify flaws and deficiencies in proving these effects and propose leads for future trials.
Methods
We searched the MEDLINE and Cochrane databases for trials, reviews and meta-analyses assessing the effect of BT injection in upper-limb spasticity. This was a non-systematic narrative review, and the selection of articles was based on the authors’ expertise. The review focused on stroke-related spasticity and disability.
Results
Patients’ therapeutic targets involved use of the disability assessment scale (DAS) or goal attainment scale (GAS). Impairments and passive function goals prevailed for active function and participation and were more frequently achieved for the former than the latter. Meta-analyses showed no to mild effect sizes for improvement in upper-limb function but failed to show higher and/or better use of the paretic upper limb in activities of daily living after BT injection.
Conclusion
BT injections for impairment and passive function are related to improved kinematic parameters; however, the relation between relief of spasticity and improved upper-limb activity has not been established. Possible explanations for the lack of functional effect in studies are first, disability is mainly due to muscle weakness rather than spasticity, so patients with the best underlying motricity may benefit the most from BT injections; second, assessment methods may not be adapted to screen eligible patients; third, most studies’ endpoints were at 4 to 12 weeks after a single injection, but repeated treatment sessions might be needed to observe functional outcome on the upper limbs; and finally, the association of rehabilitation programs or non-pharmacological treatments may enhance the functional effects of BT injections.En ligne : https://www.sciencedirect.com/science/article/pii/S187706571831409X Permalink : ./index.php?lvl=notice_display&id=84128
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 234-240[article] Does botulinum toxin treatment improve upper limb active function? [texte imprimé] / Jonathan Lévy . - 2019 . - p. 234-240.
https://doi.org/10.1016/j.rehab.2018.05.1320
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 234-240
Mots-clés : Spasticity Botulinum toxin Rehabilitation Outcome Upper limb Stroke Résumé : Background
Spasticity following lesions of the central nervous system such as stroke is a major cause of impairment and disability, especially when it affects the upper limb, and can be focally relieved by intramuscular injections of botulinum toxin (BT). Functional improvements of the affected upper limb after a BT focal treatment remain controversial.
Objective
We aimed to assess the functional effects of BT treatment on upper-limb spasticity in the literature, identify flaws and deficiencies in proving these effects and propose leads for future trials.
Methods
We searched the MEDLINE and Cochrane databases for trials, reviews and meta-analyses assessing the effect of BT injection in upper-limb spasticity. This was a non-systematic narrative review, and the selection of articles was based on the authors’ expertise. The review focused on stroke-related spasticity and disability.
Results
Patients’ therapeutic targets involved use of the disability assessment scale (DAS) or goal attainment scale (GAS). Impairments and passive function goals prevailed for active function and participation and were more frequently achieved for the former than the latter. Meta-analyses showed no to mild effect sizes for improvement in upper-limb function but failed to show higher and/or better use of the paretic upper limb in activities of daily living after BT injection.
Conclusion
BT injections for impairment and passive function are related to improved kinematic parameters; however, the relation between relief of spasticity and improved upper-limb activity has not been established. Possible explanations for the lack of functional effect in studies are first, disability is mainly due to muscle weakness rather than spasticity, so patients with the best underlying motricity may benefit the most from BT injections; second, assessment methods may not be adapted to screen eligible patients; third, most studies’ endpoints were at 4 to 12 weeks after a single injection, but repeated treatment sessions might be needed to observe functional outcome on the upper limbs; and finally, the association of rehabilitation programs or non-pharmacological treatments may enhance the functional effects of BT injections.En ligne : https://www.sciencedirect.com/science/article/pii/S187706571831409X Permalink : ./index.php?lvl=notice_display&id=84128 Exemplaires (1)
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Exclu du prêtImmunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review / Laure Mathevon in Annals of physical and rehabilitation medicine, Vol. 62, n°4 (Juillet 2019)
[article]
Titre : Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review Type de document : texte imprimé Auteurs : Laure Mathevon ; Arnaud Declemy ; Isabelle Laffont ; Dominic Pérennou Année de publication : 2019 Article en page(s) : p. 241-251 Note générale : doi.org/10.1016/j.rehab.2019.03.004 Langues : Anglais (eng) Mots-clés : Limb spasticity Botulinum toxin Immunogenicity Resistance to treatment Neutralizing antibody Résumé : Background
The imputability of neutralizing antibodies (NABs) in secondary non-response (SnR) to botulinum toxin (BoNT) injections for limb spasticity is still debated.
Objective
This systematic literature review aimed to determine the prevalence of NABs after BoNT injections for limb spasticity and analyze their determinants and their causal role in SnR.
Methods
We searched MEDLINE via PubMed, Cochrane and Embase databases for articles published during 1990–2018. Two independent reviewers extracted the data and assessed the quality of studies with a specific scale (according to PRISMA and STROBE guidelines). Because the techniques used to detect NABs did not influence the results, we calculated the global (all studies) sensitivity and specificity of NAB positivity to reveal SnR.
Results
We included 14 articles published from 2002 to 2018 (including an epublication) describing 5 randomized controlled trials and 5 interventional and 4 observational studies. The quality was satisfactory (mean score 18/28 arbitrary units). NAB detection was the primary criterion in 5 studies and a secondary criterion in 9. In total, 1234 serum samples for 1234 participants (91% with stroke) were tested after injection. NAB prevalence was about 1%, with no significant difference among formulations. NAB positivity seemed favoured by long-duration therapy with high doses and a short interval between injections. The identification of non-response by NAB positivity had poor global sensitivity (56%) but very high specificity (99.6%). No consensual criteria were used to diagnose non-response to BoNT injection.
Conclusions
NAB prevalence is much lower after BoNT treatment for limb spasticity than cervical dystonia. Consensual criteria must be defined to diagnose non-response to BoNT injection. Because immunogenicity is not the most common cause of non-response to BoNT injection, NABs should be sought in individuals with SnR with no other cause explaining the treatment inefficacy. A test with 100% specificity is recommended. In cases for which immunogenicity is the most likely cause of non-response to BoNT injections, some biological arguments suggest trying another BoNT, but no clinical evidence supports this strategy.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065719300417 Permalink : ./index.php?lvl=notice_display&id=84129
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 241-251[article] Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review [texte imprimé] / Laure Mathevon ; Arnaud Declemy ; Isabelle Laffont ; Dominic Pérennou . - 2019 . - p. 241-251.
doi.org/10.1016/j.rehab.2019.03.004
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 241-251
Mots-clés : Limb spasticity Botulinum toxin Immunogenicity Resistance to treatment Neutralizing antibody Résumé : Background
The imputability of neutralizing antibodies (NABs) in secondary non-response (SnR) to botulinum toxin (BoNT) injections for limb spasticity is still debated.
Objective
This systematic literature review aimed to determine the prevalence of NABs after BoNT injections for limb spasticity and analyze their determinants and their causal role in SnR.
Methods
We searched MEDLINE via PubMed, Cochrane and Embase databases for articles published during 1990–2018. Two independent reviewers extracted the data and assessed the quality of studies with a specific scale (according to PRISMA and STROBE guidelines). Because the techniques used to detect NABs did not influence the results, we calculated the global (all studies) sensitivity and specificity of NAB positivity to reveal SnR.
Results
We included 14 articles published from 2002 to 2018 (including an epublication) describing 5 randomized controlled trials and 5 interventional and 4 observational studies. The quality was satisfactory (mean score 18/28 arbitrary units). NAB detection was the primary criterion in 5 studies and a secondary criterion in 9. In total, 1234 serum samples for 1234 participants (91% with stroke) were tested after injection. NAB prevalence was about 1%, with no significant difference among formulations. NAB positivity seemed favoured by long-duration therapy with high doses and a short interval between injections. The identification of non-response by NAB positivity had poor global sensitivity (56%) but very high specificity (99.6%). No consensual criteria were used to diagnose non-response to BoNT injection.
Conclusions
NAB prevalence is much lower after BoNT treatment for limb spasticity than cervical dystonia. Consensual criteria must be defined to diagnose non-response to BoNT injection. Because immunogenicity is not the most common cause of non-response to BoNT injection, NABs should be sought in individuals with SnR with no other cause explaining the treatment inefficacy. A test with 100% specificity is recommended. In cases for which immunogenicity is the most likely cause of non-response to BoNT injections, some biological arguments suggest trying another BoNT, but no clinical evidence supports this strategy.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065719300417 Permalink : ./index.php?lvl=notice_display&id=84129 Exemplaires (1)
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Exclu du prêtPain during injections of botulinum toxin in children: Influence of the localization technique / M. BAYON-MOTTU in Annals of physical and rehabilitation medicine, Vol. 57, n°9-10 (Décembre 2014)
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