Focal brainstem infarction in the adult rat / Ai Namioka in LabAnimal, 05/21 (May 2021 Vol. 21 N°5)

Public ISBD [article]  inLabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 23-36 Titre : Focal brainstem infarction in the adult rat Type de document : texte imprimé Auteurs : Ai Namioka ; Takahiro Namiokai ; Masanori Sasak ; et al. Année de publication : 2021 Article en page(s) : p. 23-36 Note générale : DOI: 10.1038/s41684-021-00722-1 Langues : Anglais (eng) Mots-clés : Animals  Brain Stem Infarctions  Disease Models, Animal  Female  Humans  Rats  Rats, Sprague-Dawley  Stroke Résumé : Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia are available, and they show great variability or cause early lethality. New, reliable animal models are therefore needed. By selectively ligating four points of the lower basilar artery, we developed a new focal basilar artery occlusion model that causes a localized brainstem ischemic lesion in female Sprague–Dawley rats. Analysis of ischemic lesion volume and neurological deficits over a period of 28 d showed that the rats present symptoms specific to this type of stroke while the ischemic lesion remains relatively unchanged over time. This procedure allows higher survival rates and extended observation periods compared with other models of brainstem ischemia. The procedure takes ~40 min, can be performed by researchers with basic surgical skills and does not require specialized surgical equipment. This protocol is highly reliable and will be useful to evaluate new therapeutic approaches to promote functional recovery in patients with brainstem ischemia. Permalink : ./index.php?lvl=notice_display&id=94504 [article] Focal brainstem infarction in the adult rat [texte imprimé] / Ai Namioka ; Takahiro Namiokai ; Masanori Sasak ; et al. . - 2021 . - p. 23-36. DOI: 10.1038/s41684-021-00722-1 Langues : Anglais (eng) in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 23-36 Mots-clés : Animals  Brain Stem Infarctions  Disease Models, Animal  Female  Humans  Rats  Rats, Sprague-Dawley  Stroke Résumé : Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia are available, and they show great variability or cause early lethality. New, reliable animal models are therefore needed. By selectively ligating four points of the lower basilar artery, we developed a new focal basilar artery occlusion model that causes a localized brainstem ischemic lesion in female Sprague–Dawley rats. Analysis of ischemic lesion volume and neurological deficits over a period of 28 d showed that the rats present symptoms specific to this type of stroke while the ischemic lesion remains relatively unchanged over time. This procedure allows higher survival rates and extended observation periods compared with other models of brainstem ischemia. The procedure takes ~40 min, can be performed by researchers with basic surgical skills and does not require specialized surgical equipment. This protocol is highly reliable and will be useful to evaluate new therapeutic approaches to promote functional recovery in patients with brainstem ischemia. Permalink : ./index.php?lvl=notice_display&id=94504

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