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Lundi : 8h-18h30
Mardi : 8h-17h30
Mercredi 9h-16h30
Jeudi : 8h-18h30
Vendredi : 8h30-12h30 et 13h-14h30
Attention,
Votre centre de documentation sera fermé ce lundi 26 août.
Également, ce mercredi 28 août il sera fermé de 12 à 13h.
Enfin, ce jeudi 29 août il ouvrira à 14h45.
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Détail de l'auteur
Auteur Laure Mathevon |
Documents disponibles écrits par cet auteur
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Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review / Laure Mathevon in Annals of physical and rehabilitation medicine, Vol. 62, n°4 (Juillet 2019)
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[article]
Titre : Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review Type de document : texte imprimé Auteurs : Laure Mathevon ; Arnaud Declemy ; Isabelle Laffont ; Dominic Pérennou Année de publication : 2019 Article en page(s) : p. 241-251 Note générale : doi.org/10.1016/j.rehab.2019.03.004 Langues : Anglais (eng) Mots-clés : Limb spasticity Botulinum toxin Immunogenicity Resistance to treatment Neutralizing antibody Résumé : Background
The imputability of neutralizing antibodies (NABs) in secondary non-response (SnR) to botulinum toxin (BoNT) injections for limb spasticity is still debated.
Objective
This systematic literature review aimed to determine the prevalence of NABs after BoNT injections for limb spasticity and analyze their determinants and their causal role in SnR.
Methods
We searched MEDLINE via PubMed, Cochrane and Embase databases for articles published during 1990–2018. Two independent reviewers extracted the data and assessed the quality of studies with a specific scale (according to PRISMA and STROBE guidelines). Because the techniques used to detect NABs did not influence the results, we calculated the global (all studies) sensitivity and specificity of NAB positivity to reveal SnR.
Results
We included 14 articles published from 2002 to 2018 (including an epublication) describing 5 randomized controlled trials and 5 interventional and 4 observational studies. The quality was satisfactory (mean score 18/28 arbitrary units). NAB detection was the primary criterion in 5 studies and a secondary criterion in 9. In total, 1234 serum samples for 1234 participants (91% with stroke) were tested after injection. NAB prevalence was about 1%, with no significant difference among formulations. NAB positivity seemed favoured by long-duration therapy with high doses and a short interval between injections. The identification of non-response by NAB positivity had poor global sensitivity (56%) but very high specificity (99.6%). No consensual criteria were used to diagnose non-response to BoNT injection.
Conclusions
NAB prevalence is much lower after BoNT treatment for limb spasticity than cervical dystonia. Consensual criteria must be defined to diagnose non-response to BoNT injection. Because immunogenicity is not the most common cause of non-response to BoNT injection, NABs should be sought in individuals with SnR with no other cause explaining the treatment inefficacy. A test with 100% specificity is recommended. In cases for which immunogenicity is the most likely cause of non-response to BoNT injections, some biological arguments suggest trying another BoNT, but no clinical evidence supports this strategy.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065719300417 Permalink : ./index.php?lvl=notice_display&id=84129
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 241-251[article] Immunogenicity induced by botulinum toxin injections for limb spasticity: A systematic review [texte imprimé] / Laure Mathevon ; Arnaud Declemy ; Isabelle Laffont ; Dominic Pérennou . - 2019 . - p. 241-251.
doi.org/10.1016/j.rehab.2019.03.004
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 62, n°4 (Juillet 2019) . - p. 241-251
Mots-clés : Limb spasticity Botulinum toxin Immunogenicity Resistance to treatment Neutralizing antibody Résumé : Background
The imputability of neutralizing antibodies (NABs) in secondary non-response (SnR) to botulinum toxin (BoNT) injections for limb spasticity is still debated.
Objective
This systematic literature review aimed to determine the prevalence of NABs after BoNT injections for limb spasticity and analyze their determinants and their causal role in SnR.
Methods
We searched MEDLINE via PubMed, Cochrane and Embase databases for articles published during 1990–2018. Two independent reviewers extracted the data and assessed the quality of studies with a specific scale (according to PRISMA and STROBE guidelines). Because the techniques used to detect NABs did not influence the results, we calculated the global (all studies) sensitivity and specificity of NAB positivity to reveal SnR.
Results
We included 14 articles published from 2002 to 2018 (including an epublication) describing 5 randomized controlled trials and 5 interventional and 4 observational studies. The quality was satisfactory (mean score 18/28 arbitrary units). NAB detection was the primary criterion in 5 studies and a secondary criterion in 9. In total, 1234 serum samples for 1234 participants (91% with stroke) were tested after injection. NAB prevalence was about 1%, with no significant difference among formulations. NAB positivity seemed favoured by long-duration therapy with high doses and a short interval between injections. The identification of non-response by NAB positivity had poor global sensitivity (56%) but very high specificity (99.6%). No consensual criteria were used to diagnose non-response to BoNT injection.
Conclusions
NAB prevalence is much lower after BoNT treatment for limb spasticity than cervical dystonia. Consensual criteria must be defined to diagnose non-response to BoNT injection. Because immunogenicity is not the most common cause of non-response to BoNT injection, NABs should be sought in individuals with SnR with no other cause explaining the treatment inefficacy. A test with 100% specificity is recommended. In cases for which immunogenicity is the most likely cause of non-response to BoNT injections, some biological arguments suggest trying another BoNT, but no clinical evidence supports this strategy.En ligne : https://www.sciencedirect.com/science/article/pii/S1877065719300417 Permalink : ./index.php?lvl=notice_display&id=84129 Exemplaires (1)
Cote Support Localisation Section Disponibilité Revue Revue Centre de Documentation HELHa Campus Montignies Armoires à volets Document exclu du prêt - à consulter sur place
Exclu du prêtTilted writing after stroke, a sign of biased verticality representation / Caroline Jolly in Annals of physical and rehabilitation medicine, Vol. 63, n°1 (Janvier 2020)
[article]
Titre : Tilted writing after stroke, a sign of biased verticality representation Type de document : texte imprimé Auteurs : Caroline Jolly ; Céline Piscicelli ; Remi Gimat ; Claire Berenger ; Eric Guinet ; Laure Mathevon ; Anne Chrispin ; Shenhao Dai ; Monica Baciu ; Dominic Pérennou Année de publication : 2020 Article en page(s) : p. 85-88 Note générale : doi.org/10.1016/j.rehab.2019.12.001 Langues : Anglais (eng) Résumé : Handwriting is a complex task involving motor, linguistic, perceptual, and attentional skills predominantly controlled by the left hemisphere but requiring a spatial organization that depends on the right hemisphere [1]. Handwriting is often affected after right-hemispheric lesions, with a spectrum of signs related to the spatial layout of the written language [2], [3], [4], [5], constituting spatial dysgraphia/agraphia [2], [6], [7]. These signs are multi-faceted [2], [3], [5], [7]. Most deal with spatial compression or mental rotation of the space and are related to spatial neglect: omitting the left half of the paper, overwriting or compressing some words, and omitting and substituting letters or graphemes. Some deal with the visual processing of complex material to write (simultagnosia) [8]. Others such as tilted writing remain to be understood.
Here we present a case suggesting that the tilted handwriting after stroke might be due to a counterclockwise tilt in representing the vertical, transposed on the sheet of paper referring to top and bottom.Permalink : ./index.php?lvl=notice_display&id=90771
in Annals of physical and rehabilitation medicine > Vol. 63, n°1 (Janvier 2020) . - p. 85-88[article] Tilted writing after stroke, a sign of biased verticality representation [texte imprimé] / Caroline Jolly ; Céline Piscicelli ; Remi Gimat ; Claire Berenger ; Eric Guinet ; Laure Mathevon ; Anne Chrispin ; Shenhao Dai ; Monica Baciu ; Dominic Pérennou . - 2020 . - p. 85-88.
doi.org/10.1016/j.rehab.2019.12.001
Langues : Anglais (eng)
in Annals of physical and rehabilitation medicine > Vol. 63, n°1 (Janvier 2020) . - p. 85-88
Résumé : Handwriting is a complex task involving motor, linguistic, perceptual, and attentional skills predominantly controlled by the left hemisphere but requiring a spatial organization that depends on the right hemisphere [1]. Handwriting is often affected after right-hemispheric lesions, with a spectrum of signs related to the spatial layout of the written language [2], [3], [4], [5], constituting spatial dysgraphia/agraphia [2], [6], [7]. These signs are multi-faceted [2], [3], [5], [7]. Most deal with spatial compression or mental rotation of the space and are related to spatial neglect: omitting the left half of the paper, overwriting or compressing some words, and omitting and substituting letters or graphemes. Some deal with the visual processing of complex material to write (simultagnosia) [8]. Others such as tilted writing remain to be understood.
Here we present a case suggesting that the tilted handwriting after stroke might be due to a counterclockwise tilt in representing the vertical, transposed on the sheet of paper referring to top and bottom.Permalink : ./index.php?lvl=notice_display&id=90771 Exemplaires (1)
Cote Support Localisation Section Disponibilité Revue Revue Centre de Documentation HELHa Campus Montignies Armoires à volets Document exclu du prêt - à consulter sur place
Exclu du prêt