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Crispants take the spotlight / Wouter Masselink in LabAnimal, 05/21 (May 2021 Vol. 21 N°5)

Public ISBD [article]  inLabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 12-13 Titre : Crispants take the spotlight Type de document : texte imprimé Auteurs : Wouter Masselink Année de publication : 2021 Article en page(s) : p. 12-13 Note générale : DOI: 10.1038/s41684-021-00739-6 Langues : Anglais (eng) Mots-clés : Phenotype Résumé : A new CRISPR/Cas9 method that can generate F0 mutant zebrafish has the potential to cut costs, spare time, and reduce animal use for researchers interested in screening loss-of-function alleles in vivo. Permalink : ./index.php?lvl=notice_display&id=94501 [article] Crispants take the spotlight [texte imprimé] / Wouter Masselink . - 2021 . - p. 12-13. DOI: 10.1038/s41684-021-00739-6 Langues : Anglais (eng) in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 12-13 Mots-clés : Phenotype Résumé : A new CRISPR/Cas9 method that can generate F0 mutant zebrafish has the potential to cut costs, spare time, and reduce animal use for researchers interested in screening loss-of-function alleles in vivo. Permalink : ./index.php?lvl=notice_display&id=94501

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MODs in need / Jim Kling in LabAnimal, 05/21 (May 2021 Vol. 21 N°5)

Public ISBD [article]  inLabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 14-16 Titre : MODs in need Type de document : texte imprimé Auteurs : Jim Kling Année de publication : 2021 Article en page(s) : p. 14-16 Langues : Anglais (eng) Résumé : Following funding cuts, several model organism databases and the larger efforts that rely on their data are left facing uncertain futures. Permalink : ./index.php?lvl=notice_display&id=94502 [article] MODs in need [texte imprimé] / Jim Kling . - 2021 . - p. 14-16. Langues : Anglais (eng) in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 14-16 Résumé : Following funding cuts, several model organism databases and the larger efforts that rely on their data are left facing uncertain futures. Permalink : ./index.php?lvl=notice_display&id=94502

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Companion canines hold clues for cancer research / Alla Katsnelson in LabAnimal, 05/21 (May 2021 Vol. 21 N°5)  

Public ISBD [article]  inLabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 20-22 Titre : Companion canines hold clues for cancer research Type de document : texte imprimé Auteurs : Alla Katsnelson Année de publication : 2021 Article en page(s) : p. 20-22 Note générale : DOI: 10.1038/s41684-021-00741-y Langues : Anglais (eng) Mots-clés : Animals  Dogs  Humans  Models, Animal  Neoplasms  Pets  Research Résumé : Research using pet dogs as animal models of cancer is helping to inform treatments for human patients — and vice versa. En ligne : https://www.nature.com/articles/s41684-021-00741-y Permalink : ./index.php?lvl=notice_display&id=94503 [article] Companion canines hold clues for cancer research [texte imprimé] / Alla Katsnelson . - 2021 . - p. 20-22. DOI: 10.1038/s41684-021-00741-y Langues : Anglais (eng) in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 20-22 Mots-clés : Animals  Dogs  Humans  Models, Animal  Neoplasms  Pets  Research Résumé : Research using pet dogs as animal models of cancer is helping to inform treatments for human patients — and vice versa. En ligne : https://www.nature.com/articles/s41684-021-00741-y Permalink : ./index.php?lvl=notice_display&id=94503

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Focal brainstem infarction in the adult rat / Ai Namioka in LabAnimal, 05/21 (May 2021 Vol. 21 N°5)

Public ISBD [article]  inLabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 23-36 Titre : Focal brainstem infarction in the adult rat Type de document : texte imprimé Auteurs : Ai Namioka ; Takahiro Namiokai ; Masanori Sasak ; et al. Année de publication : 2021 Article en page(s) : p. 23-36 Note générale : DOI: 10.1038/s41684-021-00722-1 Langues : Anglais (eng) Mots-clés : Animals  Brain Stem Infarctions  Disease Models, Animal  Female  Humans  Rats  Rats, Sprague-Dawley  Stroke Résumé : Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia are available, and they show great variability or cause early lethality. New, reliable animal models are therefore needed. By selectively ligating four points of the lower basilar artery, we developed a new focal basilar artery occlusion model that causes a localized brainstem ischemic lesion in female Sprague–Dawley rats. Analysis of ischemic lesion volume and neurological deficits over a period of 28 d showed that the rats present symptoms specific to this type of stroke while the ischemic lesion remains relatively unchanged over time. This procedure allows higher survival rates and extended observation periods compared with other models of brainstem ischemia. The procedure takes ~40 min, can be performed by researchers with basic surgical skills and does not require specialized surgical equipment. This protocol is highly reliable and will be useful to evaluate new therapeutic approaches to promote functional recovery in patients with brainstem ischemia. Permalink : ./index.php?lvl=notice_display&id=94504 [article] Focal brainstem infarction in the adult rat [texte imprimé] / Ai Namioka ; Takahiro Namiokai ; Masanori Sasak ; et al. . - 2021 . - p. 23-36. DOI: 10.1038/s41684-021-00722-1 Langues : Anglais (eng) in LabAnimal > 05/21 (May 2021 Vol. 21 N°5) . - p. 23-36 Mots-clés : Animals  Brain Stem Infarctions  Disease Models, Animal  Female  Humans  Rats  Rats, Sprague-Dawley  Stroke Résumé : Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia are available, and they show great variability or cause early lethality. New, reliable animal models are therefore needed. By selectively ligating four points of the lower basilar artery, we developed a new focal basilar artery occlusion model that causes a localized brainstem ischemic lesion in female Sprague–Dawley rats. Analysis of ischemic lesion volume and neurological deficits over a period of 28 d showed that the rats present symptoms specific to this type of stroke while the ischemic lesion remains relatively unchanged over time. This procedure allows higher survival rates and extended observation periods compared with other models of brainstem ischemia. The procedure takes ~40 min, can be performed by researchers with basic surgical skills and does not require specialized surgical equipment. This protocol is highly reliable and will be useful to evaluate new therapeutic approaches to promote functional recovery in patients with brainstem ischemia. Permalink : ./index.php?lvl=notice_display&id=94504

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