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Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis / Medhat Sdeek in Acta Orthopaedica Belgica, Vol. 87/4 (Décembre 2021)
[article]
Titre : Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis : a prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years Type de document : texte imprimé Auteurs : Medhat Sdeek ; Dian Sabry ; Hisham El-Sdeek Année de publication : 2021 Article en page(s) : p. 729-734 Note générale : https://doi.org/10.52628/87.4.18 Langues : Anglais (eng) Mots-clés : Platelet-rich plasma Hyaluronic acid growth factors intra-articular Résumé : Platelet-rich plasma injections have been proposed as an option for Conservative management of knee Osteoarthritis to provide symptomatic relief and also to delay the need for surgical intervention. Although almost all the current literatures provide some evidence on the benefits of this technique compared with Visco- supplementation, no studies have been performed to compare their Clinical outcomes. The purpose is to compare the Clinical outcomes provided by intra- articular injection of either Platelet rich plasma or Hyaluronic acid to treat knee Osteoarthritis.
Study Design: Randomized Controlled Trial
200 Patients with a history of Symptomatic knee Osteo- arthritis (Kellgren-Lawrence grade 2 or 3) were randomized to undergo 3 blinded intra-articular in- jections of either Platelet rich plasma or Hyaluronic acid. The Interval between successive injections was 2 weeks. Patients were evaluated prospectively before the injection and then at 2, 6, 12, 24, 30 and 36 months. Evaluation was based on International Knee Documentation Committee (IKDC), Visual analog scale, VOMAC Score and the re- injection rate; 189 patients reached the final evaluation. Both platelet rich plasma and Hyaluronic acid were effective in improving knee Symptoms and functional status over time and remained stable over time up to 18 months Post-injection (No re-injection has been performed to any patient incorporated in this study during the first 18 months). The performed re-injections have been significantly lower in the PRP group. Both platelet rich plasma and Hyaluronic acid were effective in improving knee Symptoms and functional status over time and remained stable over time up to 18 months Post-injection. The rate of the required re-injections has been significantly lower in platelet rich plasma group. platelet rich plasma provide longer duration of symptomatic relief, longer duration of functional status improvement and lesser number of needed re-injections than Hyaluronic acid when the patients have been followed through 36 months.Permalink : ./index.php?lvl=notice_display&id=102053
in Acta Orthopaedica Belgica > Vol. 87/4 (Décembre 2021) . - p. 729-734[article] Intra-articular injection of Platelet rich plasma versus Hyaluronic acid for moderate knee osteoarthritis : a prospective, double-blind randomized controlled trial on 189 patients with follow-up for three years [texte imprimé] / Medhat Sdeek ; Dian Sabry ; Hisham El-Sdeek . - 2021 . - p. 729-734.
https://doi.org/10.52628/87.4.18
Langues : Anglais (eng)
in Acta Orthopaedica Belgica > Vol. 87/4 (Décembre 2021) . - p. 729-734
Mots-clés : Platelet-rich plasma Hyaluronic acid growth factors intra-articular Résumé : Platelet-rich plasma injections have been proposed as an option for Conservative management of knee Osteoarthritis to provide symptomatic relief and also to delay the need for surgical intervention. Although almost all the current literatures provide some evidence on the benefits of this technique compared with Visco- supplementation, no studies have been performed to compare their Clinical outcomes. The purpose is to compare the Clinical outcomes provided by intra- articular injection of either Platelet rich plasma or Hyaluronic acid to treat knee Osteoarthritis.
Study Design: Randomized Controlled Trial
200 Patients with a history of Symptomatic knee Osteo- arthritis (Kellgren-Lawrence grade 2 or 3) were randomized to undergo 3 blinded intra-articular in- jections of either Platelet rich plasma or Hyaluronic acid. The Interval between successive injections was 2 weeks. Patients were evaluated prospectively before the injection and then at 2, 6, 12, 24, 30 and 36 months. Evaluation was based on International Knee Documentation Committee (IKDC), Visual analog scale, VOMAC Score and the re- injection rate; 189 patients reached the final evaluation. Both platelet rich plasma and Hyaluronic acid were effective in improving knee Symptoms and functional status over time and remained stable over time up to 18 months Post-injection (No re-injection has been performed to any patient incorporated in this study during the first 18 months). The performed re-injections have been significantly lower in the PRP group. Both platelet rich plasma and Hyaluronic acid were effective in improving knee Symptoms and functional status over time and remained stable over time up to 18 months Post-injection. The rate of the required re-injections has been significantly lower in platelet rich plasma group. platelet rich plasma provide longer duration of symptomatic relief, longer duration of functional status improvement and lesser number of needed re-injections than Hyaluronic acid when the patients have been followed through 36 months.Permalink : ./index.php?lvl=notice_display&id=102053 Réservation
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DisponiblePlatelet-rich plasma vs platelet-rich plasma plus hyaluronic acid for haemophilic knee arthropathy treatment / Maria Eulalia Landro in Acta Orthopaedica Belgica, Vol. 87/4 (Décembre 2021)
[article]
Titre : Platelet-rich plasma vs platelet-rich plasma plus hyaluronic acid for haemophilic knee arthropathy treatment Type de document : texte imprimé Auteurs : Maria Eulalia Landro ; Carla Daffunchio ; Guillermo Cambiaggi ; Gustavo Galatro Année de publication : 2021 Article en page(s) : p. 705-712 Note générale : https://doi.org/10.52628/87.4.15 Langues : Anglais (eng) Mots-clés : Knee arthropathy haemophilia platelet-rich plasma hyaluronic acid Résumé : Repeated joint bleeding leads to chronic synovitis, cartilage damage and bone alterations which result in haemophilic arthropathy and are associated with pain, functional impairment and poor quality of life. There are evidence that Hyaluronic Acid (HA) and Platelet-rich Plasma (PRP) have different mechanisms of action in the treatment of arthropathy for this reason we decided to use both components. The aim of this study is to compare, the efficacy, safety and duration of a single intra-articular injection of PRP against PRP+HA for pain, bleeding episodes and joint health, in the same patient with bilateral hemophilic knee arthropathy. Twenty-one men patients (42 knee joints) were treated with intra- articular injections of PRP or PRP+HA. All of them were haemophilia type A severe. The mean age was 36.6 years (21-72). All patients were evaluated for: Haemophilia Joint Health Score (HJHS), pain (VAS), the number of bleeding episodes (BE) in the last 30 days, before treatment, at three and six months after treatment. Statistically significant improvement were shown for both knee joints at three and six months after treatment for VAS and BE (P < 0.00001). The HJHS score did not significantly improve for either knee in the 6-month period after injection. A single PRP or PRP+HA injection is safe and effective in treating haemophilic arthropathy of the knee for up to 6 months follow-up, reducing pain, bleeding episodes and delaying total knee arthroplasty. Permalink : ./index.php?lvl=notice_display&id=102050
in Acta Orthopaedica Belgica > Vol. 87/4 (Décembre 2021) . - p. 705-712[article] Platelet-rich plasma vs platelet-rich plasma plus hyaluronic acid for haemophilic knee arthropathy treatment [texte imprimé] / Maria Eulalia Landro ; Carla Daffunchio ; Guillermo Cambiaggi ; Gustavo Galatro . - 2021 . - p. 705-712.
https://doi.org/10.52628/87.4.15
Langues : Anglais (eng)
in Acta Orthopaedica Belgica > Vol. 87/4 (Décembre 2021) . - p. 705-712
Mots-clés : Knee arthropathy haemophilia platelet-rich plasma hyaluronic acid Résumé : Repeated joint bleeding leads to chronic synovitis, cartilage damage and bone alterations which result in haemophilic arthropathy and are associated with pain, functional impairment and poor quality of life. There are evidence that Hyaluronic Acid (HA) and Platelet-rich Plasma (PRP) have different mechanisms of action in the treatment of arthropathy for this reason we decided to use both components. The aim of this study is to compare, the efficacy, safety and duration of a single intra-articular injection of PRP against PRP+HA for pain, bleeding episodes and joint health, in the same patient with bilateral hemophilic knee arthropathy. Twenty-one men patients (42 knee joints) were treated with intra- articular injections of PRP or PRP+HA. All of them were haemophilia type A severe. The mean age was 36.6 years (21-72). All patients were evaluated for: Haemophilia Joint Health Score (HJHS), pain (VAS), the number of bleeding episodes (BE) in the last 30 days, before treatment, at three and six months after treatment. Statistically significant improvement were shown for both knee joints at three and six months after treatment for VAS and BE (P < 0.00001). The HJHS score did not significantly improve for either knee in the 6-month period after injection. A single PRP or PRP+HA injection is safe and effective in treating haemophilic arthropathy of the knee for up to 6 months follow-up, reducing pain, bleeding episodes and delaying total knee arthroplasty. Permalink : ./index.php?lvl=notice_display&id=102050 Réservation
Réserver ce document
Exemplaires (1)
Cote Support Localisation Section Disponibilité Revue Revue Centre de Documentation HELHa Campus Montignies Armoires à volets Disponible
Disponible