Dépouillements

A systematic review of porcine models in translational pain research / Suzan Meijs in LabAnimal, Vol. 21 N°12 (December 2021)

Public ISBD [article]  inLabAnimal > Vol. 21 N°12 (December 2021) . - p. 8-24 Titre : A systematic review of porcine models in translational pain research Type de document : texte imprimé Auteurs : Suzan Meijs ; Martin Schmelz ; Sigal Meilin ; Winnie Jensen Année de publication : 2021 Article en page(s) : p. 8-24 Langues : Anglais (eng) Mots-clés : Animals  Models, Animal  Pain / veterinary  Pain Measurement  Proteomics  Swine  Translational Research, Biomedical  Systematic Review Résumé : Translating basic pain research from rodents to humans has proven to be a challenging task. Efforts have been made to develop preclinical large animal models of pain, such as the pig. However, no consistent overview and comparison of pig models of pain are currently available. Therefore, in this review, our primary aim was to identify the available pig models in pain research and compare these models in terms of intensity and duration. First, we systematically searched Proquest, Scopus and Web of Science and compared the duration for which the pigs were significantly sensitized as well as the intensity of mechanical sensitization. We searched models within the specific field of pain and adjacent fields in which pain induction or assessment is relevant, such as pig production. Second, we compared assessment methodologies in surrogate pain models in humans and pigs to identify areas of overlap and possible improvement. Based on the literature search, 23 types of porcine pain models were identified; 13 of which could be compared quantitatively. The induced sensitization lasted from hours to months and intensities ranged from insignificant to the maximum attainable. We also found a near to complete overlap of assessment methodologies between human and pig models within the area of peripheral neurophysiology, which allows for direct comparison of results obtained in the two species. In spite of this overlap, further development of pain assessment methodologies is still needed. We suggest that central nervous system electrophysiology, such as electroencephalography, electrocorticography or intracortical recordings, may pave the way for future objective pain assessment. Permalink : ./index.php?lvl=notice_display&id=99011 [article] A systematic review of porcine models in translational pain research [texte imprimé] / Suzan Meijs ; Martin Schmelz ; Sigal Meilin ; Winnie Jensen . - 2021 . - p. 8-24. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°12 (December 2021) . - p. 8-24 Mots-clés : Animals  Models, Animal  Pain / veterinary  Pain Measurement  Proteomics  Swine  Translational Research, Biomedical  Systematic Review Résumé : Translating basic pain research from rodents to humans has proven to be a challenging task. Efforts have been made to develop preclinical large animal models of pain, such as the pig. However, no consistent overview and comparison of pig models of pain are currently available. Therefore, in this review, our primary aim was to identify the available pig models in pain research and compare these models in terms of intensity and duration. First, we systematically searched Proquest, Scopus and Web of Science and compared the duration for which the pigs were significantly sensitized as well as the intensity of mechanical sensitization. We searched models within the specific field of pain and adjacent fields in which pain induction or assessment is relevant, such as pig production. Second, we compared assessment methodologies in surrogate pain models in humans and pigs to identify areas of overlap and possible improvement. Based on the literature search, 23 types of porcine pain models were identified; 13 of which could be compared quantitatively. The induced sensitization lasted from hours to months and intensities ranged from insignificant to the maximum attainable. We also found a near to complete overlap of assessment methodologies between human and pig models within the area of peripheral neurophysiology, which allows for direct comparison of results obtained in the two species. In spite of this overlap, further development of pain assessment methodologies is still needed. We suggest that central nervous system electrophysiology, such as electroencephalography, electrocorticography or intracortical recordings, may pave the way for future objective pain assessment. Permalink : ./index.php?lvl=notice_display&id=99011

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

The impact of COVID-19 lockdowns on the genetic integrity of your mouse colonies / Natalia Moncaut in LabAnimal, Vol. 21 N°12 (December 2021)  

Public ISBD [article]  inLabAnimal > Vol. 21 N°12 (December 2021) . - p. 25-26 Titre : The impact of COVID-19 lockdowns on the genetic integrity of your mouse colonies Type de document : texte imprimé Auteurs : Natalia Moncaut ; Sarah Hart-Johnson Année de publication : 2021 Article en page(s) : p. 25-26 Langues : Anglais (eng) Mots-clés : Animals  COVID-19  Communicable Disease Control  Humans  Mice  SARS-CoV-2 En ligne : https://www.nature.com/articles/s41684-021-00872-2 Permalink : ./index.php?lvl=notice_display&id=99012 [article] The impact of COVID-19 lockdowns on the genetic integrity of your mouse colonies [texte imprimé] / Natalia Moncaut ; Sarah Hart-Johnson . - 2021 . - p. 25-26. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°12 (December 2021) . - p. 25-26 Mots-clés : Animals  COVID-19  Communicable Disease Control  Humans  Mice  SARS-CoV-2 En ligne : https://www.nature.com/articles/s41684-021-00872-2 Permalink : ./index.php?lvl=notice_display&id=99012

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

Guideline for the Care and Use of Laboratory Animals in Iran / Siavash Ahmadi-Noorbakhsh in LabAnimal, Vol. 21 N°12 (December 2021)

Public ISBD [article]  inLabAnimal > Vol. 21 N°12 (December 2021) . - p. 27-29 Titre : Guideline for the Care and Use of Laboratory Animals in Iran Type de document : texte imprimé Auteurs : Siavash Ahmadi-Noorbakhsh ; Esmat Mirabzadeh Ardakani ; Jila Sadighi Année de publication : 2021 Article en page(s) : p. 27-29 Langues : Anglais (eng) Mots-clés : Animals  Animals, Laboratory  Iran Permalink : ./index.php?lvl=notice_display&id=99013 [article] Guideline for the Care and Use of Laboratory Animals in Iran [texte imprimé] / Siavash Ahmadi-Noorbakhsh ; Esmat Mirabzadeh Ardakani ; Jila Sadighi . - 2021 . - p. 27-29. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°12 (December 2021) . - p. 27-29 Mots-clés : Animals  Animals, Laboratory  Iran Permalink : ./index.php?lvl=notice_display&id=99013

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

Development and characterization of a new swine model of invasive pneumococcal pneumonia / Rosanel Amaro in LabAnimal, Vol. 21 N°12 (December 2021)  

Public ISBD [article]  inLabAnimal > Vol. 21 N°12 (December 2021) . - p. 30-41 Titre : Development and characterization of a new swine model of invasive pneumococcal pneumonia Type de document : texte imprimé Auteurs : Rosanel Amaro ; Gianluigi Li Bassi ; Ana Motos ; et al. Année de publication : 2021 Article en page(s) : p. 30-41 Langues : Anglais (eng) Mots-clés : Animals  Anti-Bacterial Agents / therapeutic use  Drug Resistance, Bacterial  Humans  Macrolides / pharmacology  Pneumonia, Pneumococcal / drug therapy  Pneumonia, Pneumococcal / veterinary  Streptococcus pneumoniae  Swine Résumé : Streptococcus pneumoniae is the most common microbial cause of community-acquired pneumonia. Currently, there are no available models of severe pneumococcal pneumonia in mechanically ventilated animals to mimic clinical conditions of critically ill patients. We studied endogenous pulmonary flora in 4 healthy pigs and in an additional 10 pigs in which we intra-bronchially instilled S. pneumoniae serotype 19 A, characterized by its resistance to penicillin, macrolides and tetracyclines. The pigs underwent ventilation for 72 h. All pigs that were not challenged with S. pneumoniae completed the 72-h study, whereas 30% of infected pigs did not. At 24 h, we clinically confirmed pneumonia in the infected pigs; upon necropsy, we sampled lung tissue for microbiological/histological confirmation of pneumococcal pneumonia. In control pigs, Streptococcus suis and Staphylococcus aureus were the most commonly encountered pathogens, and their lung tissue mean ± s.e.m. concentration was 7.94 ± 20 c.f.u./g. In infected pigs, S. pneumoniae was found in the lungs of all pigs (mean ± s.e.m. pulmonary concentration of 1.26 × 105 ± 2 × 102 c.f.u./g). Bacteremia was found in 50% of infected pigs. Pneumococcal pneumonia was confirmed in all infected pigs at 24 h. Pneumonia was associated with thrombocytopenia, an increase in prothrombin time, cardiac output and vasopressor dependency index and a decrease in systemic vascular resistance. Upon necropsy, microbiological/histological pneumococcal pneumonia was confirmed in 8 of 10 pigs. We have therefore developed a novel model of penicillin- and macrolide-resistant pneumococcal pneumonia in mechanically ventilated pigs with bacteremia and severe hemodynamic compromise. The model could prove valuable for appraising the pathogenesis of pneumococcal pneumonia, the effects associated with macrolide resistance and the outcomes related to the use of new diagnostic strategies and antibiotic or complementary therapies. En ligne : https://www.nature.com/articles/s41684-021-00876-y Permalink : ./index.php?lvl=notice_display&id=99014 [article] Development and characterization of a new swine model of invasive pneumococcal pneumonia [texte imprimé] / Rosanel Amaro ; Gianluigi Li Bassi ; Ana Motos ; et al. . - 2021 . - p. 30-41. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°12 (December 2021) . - p. 30-41 Mots-clés : Animals  Anti-Bacterial Agents / therapeutic use  Drug Resistance, Bacterial  Humans  Macrolides / pharmacology  Pneumonia, Pneumococcal / drug therapy  Pneumonia, Pneumococcal / veterinary  Streptococcus pneumoniae  Swine Résumé : Streptococcus pneumoniae is the most common microbial cause of community-acquired pneumonia. Currently, there are no available models of severe pneumococcal pneumonia in mechanically ventilated animals to mimic clinical conditions of critically ill patients. We studied endogenous pulmonary flora in 4 healthy pigs and in an additional 10 pigs in which we intra-bronchially instilled S. pneumoniae serotype 19 A, characterized by its resistance to penicillin, macrolides and tetracyclines. The pigs underwent ventilation for 72 h. All pigs that were not challenged with S. pneumoniae completed the 72-h study, whereas 30% of infected pigs did not. At 24 h, we clinically confirmed pneumonia in the infected pigs; upon necropsy, we sampled lung tissue for microbiological/histological confirmation of pneumococcal pneumonia. In control pigs, Streptococcus suis and Staphylococcus aureus were the most commonly encountered pathogens, and their lung tissue mean ± s.e.m. concentration was 7.94 ± 20 c.f.u./g. In infected pigs, S. pneumoniae was found in the lungs of all pigs (mean ± s.e.m. pulmonary concentration of 1.26 × 105 ± 2 × 102 c.f.u./g). Bacteremia was found in 50% of infected pigs. Pneumococcal pneumonia was confirmed in all infected pigs at 24 h. Pneumonia was associated with thrombocytopenia, an increase in prothrombin time, cardiac output and vasopressor dependency index and a decrease in systemic vascular resistance. Upon necropsy, microbiological/histological pneumococcal pneumonia was confirmed in 8 of 10 pigs. We have therefore developed a novel model of penicillin- and macrolide-resistant pneumococcal pneumonia in mechanically ventilated pigs with bacteremia and severe hemodynamic compromise. The model could prove valuable for appraising the pathogenesis of pneumococcal pneumonia, the effects associated with macrolide resistance and the outcomes related to the use of new diagnostic strategies and antibiotic or complementary therapies. En ligne : https://www.nature.com/articles/s41684-021-00876-y Permalink : ./index.php?lvl=notice_display&id=99014

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible