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STÉRILISATION TEMPORAIRE ET DÉFINITIVE CHEZ LE MÂLE / Alain Fontbonne in Le Point vétérinaire, Vol.53 N°441 (mai 2023)
[article]
Titre : STÉRILISATION TEMPORAIRE ET DÉFINITIVE CHEZ LE MÂLE Type de document : texte imprimé Auteurs : Alain Fontbonne Année de publication : 2023 Article en page(s) : p. 12-16 Langues : Français (fre) Mots-clés : Implant castration mâle male chat chien prévention Résumé : La stérilisation chirurgicale par l’ablation bilatérale des testicules est destinée à empêcher définitivement la reproduction et permet de lutter contre la surpopulation animale en limitant l’abandon d’animaux non désirés et en améliorant le confort de vie du propriétaire avec son animal [8]. Cependant, la stérilisation chirurgicale présente aussi des inconvénients tels que son côté définitif, la prise de poids qu’elle peut entraîner ou l’augmentation du risque d’apparition de certaines affections. En outre, certains propriétaires sont réticents à l’idée d’infliger une intervention à leur animal et l’implant semble être une option à ne pas négliger. L’implant sous-cutané de desloréline bénéficie d’une autorisation de mise sur le marché (AMM) chez le chien et désormais également chez le chat. Permalink : ./index.php?lvl=notice_display&id=110513
in Le Point vétérinaire > Vol.53 N°441 (mai 2023) . - p. 12-16[article] STÉRILISATION TEMPORAIRE ET DÉFINITIVE CHEZ LE MÂLE [texte imprimé] / Alain Fontbonne . - 2023 . - p. 12-16.
Langues : Français (fre)
in Le Point vétérinaire > Vol.53 N°441 (mai 2023) . - p. 12-16
Mots-clés : Implant castration mâle male chat chien prévention Résumé : La stérilisation chirurgicale par l’ablation bilatérale des testicules est destinée à empêcher définitivement la reproduction et permet de lutter contre la surpopulation animale en limitant l’abandon d’animaux non désirés et en améliorant le confort de vie du propriétaire avec son animal [8]. Cependant, la stérilisation chirurgicale présente aussi des inconvénients tels que son côté définitif, la prise de poids qu’elle peut entraîner ou l’augmentation du risque d’apparition de certaines affections. En outre, certains propriétaires sont réticents à l’idée d’infliger une intervention à leur animal et l’implant semble être une option à ne pas négliger. L’implant sous-cutané de desloréline bénéficie d’une autorisation de mise sur le marché (AMM) chez le chien et désormais également chez le chat. Permalink : ./index.php?lvl=notice_display&id=110513 Réservation
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DisponibleCollection of untainted urinary specimens from the bladder of an anesthetized rabbit. / Patrick A. Walsh in LabAnimal-Europe, 04/16 (avril 2016)
[article]
Titre : Collection of untainted urinary specimens from the bladder of an anesthetized rabbit. Type de document : texte imprimé Auteurs : Patrick A. Walsh Année de publication : 2016 Article en page(s) : p. 20-22 Langues : Anglais (eng) Mots-clés : Anesthesia/veterinary Animals Catheters, Indwelling/veterinary Male Rabbits* Urinary Bladder* Urinary Catheterization/methods Urinary Catheterization/veterinary* Urine Specimen Collection/methods Urine Specimen Collection/veterinary* Résumé : It is difficult to collect untainted urine specimens over short intervals of time during renal studies with rabbits. This is because both the ureters and the bladder of this species are relatively friable and minor manipulation can easily cause intraluminal bleeding. We have developed and refined an effective technique and protocol for placing an indwelling urinary bladder catheter into an anesthetized rabbit. The procedure is easy to perform and completely effective and reliable, allowing high-quality urinary specimens to be collected at intervals of 15-20 min over a period of 3-4 hours during a study of acute metabolic acidosis. Permalink : ./index.php?lvl=notice_display&id=76496
in LabAnimal-Europe > 04/16 (avril 2016) . - p. 20-22[article] Collection of untainted urinary specimens from the bladder of an anesthetized rabbit. [texte imprimé] / Patrick A. Walsh . - 2016 . - p. 20-22.
Langues : Anglais (eng)
in LabAnimal-Europe > 04/16 (avril 2016) . - p. 20-22
Mots-clés : Anesthesia/veterinary Animals Catheters, Indwelling/veterinary Male Rabbits* Urinary Bladder* Urinary Catheterization/methods Urinary Catheterization/veterinary* Urine Specimen Collection/methods Urine Specimen Collection/veterinary* Résumé : It is difficult to collect untainted urine specimens over short intervals of time during renal studies with rabbits. This is because both the ureters and the bladder of this species are relatively friable and minor manipulation can easily cause intraluminal bleeding. We have developed and refined an effective technique and protocol for placing an indwelling urinary bladder catheter into an anesthetized rabbit. The procedure is easy to perform and completely effective and reliable, allowing high-quality urinary specimens to be collected at intervals of 15-20 min over a period of 3-4 hours during a study of acute metabolic acidosis. Permalink : ./index.php?lvl=notice_display&id=76496 Réservation
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DisponibleLack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats / Alan Cowan in LabAnimal-Europe, 02/16 (février 2016)
[article]
Titre : Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats Type de document : texte imprimé Auteurs : Alan Cowan, Auteur Année de publication : 2016 Article en page(s) : p. 18-27 Langues : Anglais (eng) Mots-clés : Analgesics, Opioid/adverse effects* Animals Body Weight/drug effects Buprenorphine/adverse effects* Delayed-Action Preparations Dose-Response Relationship, Drug Female Injections, Subcutaneous Male Nausea/chemically induced Postoperative Period Rats, Inbred F344 Analgesics, Opioid Buprenorphine Résumé : Abstract
Extended-release buprenorphine is an effective analgesic in laboratory animals, and its safety has been established in mice but not in rats. The authors used a target animal safety trial to evaluate the safety of extended-release buprenorphine in rats. Fischer 344 rats received post-surgical subcutaneous injections of 1.3 mg, 3.9 mg or 6.5 mg buprenorphine per kg body weight (two times, six times or ten times the intended dose, respectively), and their body weight, clinical signs and symptoms, clinical pathology and histopathology were monitored for 4 d. Body weight was not significantly different in rats that received buprenorphine compared with control rats. Signs of nausea-related behavior were observed in 25% of the rats treated with buprenorphine. Clinical pathology results for all rats were normal, and gross and microscopic histopathology examinations identified no substantial abnormalities, suggesting that this behavior was of minor consequence. Other adverse events previously reported to occur with opiate therapy, including weight loss and dermal lesions at drug injection sites, were not observed in this study. The results of this study show that post-surgical administration of an extended-release buprenorphine product is safe in Fischer 344 rats and does not necessarily cause substantial adverse effects, confirming that opiate therapy is a viable choice in laboratory animal medicine.Permalink : ./index.php?lvl=notice_display&id=66490
in LabAnimal-Europe > 02/16 (février 2016) . - p. 18-27[article] Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats [texte imprimé] / Alan Cowan, Auteur . - 2016 . - p. 18-27.
Langues : Anglais (eng)
in LabAnimal-Europe > 02/16 (février 2016) . - p. 18-27
Mots-clés : Analgesics, Opioid/adverse effects* Animals Body Weight/drug effects Buprenorphine/adverse effects* Delayed-Action Preparations Dose-Response Relationship, Drug Female Injections, Subcutaneous Male Nausea/chemically induced Postoperative Period Rats, Inbred F344 Analgesics, Opioid Buprenorphine Résumé : Abstract
Extended-release buprenorphine is an effective analgesic in laboratory animals, and its safety has been established in mice but not in rats. The authors used a target animal safety trial to evaluate the safety of extended-release buprenorphine in rats. Fischer 344 rats received post-surgical subcutaneous injections of 1.3 mg, 3.9 mg or 6.5 mg buprenorphine per kg body weight (two times, six times or ten times the intended dose, respectively), and their body weight, clinical signs and symptoms, clinical pathology and histopathology were monitored for 4 d. Body weight was not significantly different in rats that received buprenorphine compared with control rats. Signs of nausea-related behavior were observed in 25% of the rats treated with buprenorphine. Clinical pathology results for all rats were normal, and gross and microscopic histopathology examinations identified no substantial abnormalities, suggesting that this behavior was of minor consequence. Other adverse events previously reported to occur with opiate therapy, including weight loss and dermal lesions at drug injection sites, were not observed in this study. The results of this study show that post-surgical administration of an extended-release buprenorphine product is safe in Fischer 344 rats and does not necessarily cause substantial adverse effects, confirming that opiate therapy is a viable choice in laboratory animal medicine.Permalink : ./index.php?lvl=notice_display&id=66490 Réservation
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DisponiblePercutaneous microembolization of the left coronary artery to model ischemic heart disease in rats / Allard Wagenaar in LabAnimal-Europe, 02/16 (février 2016)
[article]
Titre : Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats Type de document : texte imprimé Auteurs : Allard Wagenaar Année de publication : 2016 Article en page(s) : p. 29-37 Langues : Anglais (eng) Mots-clés : Animals Cardiac Catheterization Coronary Vessels/surgery Disease Models, Animal Embolism/complications Male Microspheres Myocardial Infarction/etiology Myocardial Ischemia*/etiology Polyethylene Rats, Sprague-Dawley Résumé : Abstract
Small animal models of myocardial infarction are used for a wide variety of research purposes, but common techniques for generating such models require thoracic surgeries that increase mortality risk and damage important structures, such as the pericardial sac. Here, we describe a technique for modeling myocardial infarction in rats by selective coronary microembolization, which has hitherto been described only in large animals. This technique selectively catheterizes the left coronary artery using a custom-made catheter that is introduced and precisely placed under fluoroscopic guidance. Microspheres are then injected through the catheter to cause embolization. This process creates multiple simultaneous micro-infarcts that resemble those from clinical embolization after a percutaneous coronary intervention. As this technique does not require thoracic surgery, a low attrition rate was expected and once it was optimized, this technique had a low mortality rate of just 14% during experimental application. This technique creates infarcts that appear small but are associated with transient ECG changes and a persistently lower ejection fraction after embolization. Microspheres are retained in the myocardial tissue and are visible by epifluorescent microscopy after histological staining and recognizable as a distinct speckle pattern in ultrasound images.Permalink : ./index.php?lvl=notice_display&id=66489
in LabAnimal-Europe > 02/16 (février 2016) . - p. 29-37[article] Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats [texte imprimé] / Allard Wagenaar . - 2016 . - p. 29-37.
Langues : Anglais (eng)
in LabAnimal-Europe > 02/16 (février 2016) . - p. 29-37
Mots-clés : Animals Cardiac Catheterization Coronary Vessels/surgery Disease Models, Animal Embolism/complications Male Microspheres Myocardial Infarction/etiology Myocardial Ischemia*/etiology Polyethylene Rats, Sprague-Dawley Résumé : Abstract
Small animal models of myocardial infarction are used for a wide variety of research purposes, but common techniques for generating such models require thoracic surgeries that increase mortality risk and damage important structures, such as the pericardial sac. Here, we describe a technique for modeling myocardial infarction in rats by selective coronary microembolization, which has hitherto been described only in large animals. This technique selectively catheterizes the left coronary artery using a custom-made catheter that is introduced and precisely placed under fluoroscopic guidance. Microspheres are then injected through the catheter to cause embolization. This process creates multiple simultaneous micro-infarcts that resemble those from clinical embolization after a percutaneous coronary intervention. As this technique does not require thoracic surgery, a low attrition rate was expected and once it was optimized, this technique had a low mortality rate of just 14% during experimental application. This technique creates infarcts that appear small but are associated with transient ECG changes and a persistently lower ejection fraction after embolization. Microspheres are retained in the myocardial tissue and are visible by epifluorescent microscopy after histological staining and recognizable as a distinct speckle pattern in ultrasound images.Permalink : ./index.php?lvl=notice_display&id=66489 Réservation
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