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Votre centre de documentation fermera de 12h30 à 13h ce vendredi 28 juin et fermera à 14h30.
Dès ce lundi 1er juillet jusqu'au mercredi 10 juillet l'horaire du centre de documentation sera adapté :
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Mercredi 3 juillet : de 9h à 12h et de 12h30 à 15h15
Jeudi 4 juillet : de 8h à 12h30 et de 13h à 18h30
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Réouverture dès ce lundi 19 août.
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Guideline for the Care and Use of Laboratory Animals in Iran / Siavash Ahmadi-Noorbakhsh in LabAnimal, Vol. 21 N°12 (December 2021)
[article]
Titre : Guideline for the Care and Use of Laboratory Animals in Iran Type de document : texte imprimé Auteurs : Siavash Ahmadi-Noorbakhsh ; Esmat Mirabzadeh Ardakani ; Jila Sadighi Année de publication : 2021 Article en page(s) : p. 27-29 Langues : Anglais (eng) Mots-clés : Animals Animals, Laboratory Iran Permalink : ./index.php?lvl=notice_display&id=99013
in LabAnimal > Vol. 21 N°12 (December 2021) . - p. 27-29[article] Guideline for the Care and Use of Laboratory Animals in Iran [texte imprimé] / Siavash Ahmadi-Noorbakhsh ; Esmat Mirabzadeh Ardakani ; Jila Sadighi . - 2021 . - p. 27-29.
Langues : Anglais (eng)
in LabAnimal > Vol. 21 N°12 (December 2021) . - p. 27-29
Mots-clés : Animals Animals, Laboratory Iran Permalink : ./index.php?lvl=notice_display&id=99013 Réservation
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DisponibleMethods for measuring pain in laboratory animals. / Dustin M. Graham in LabAnimal-Europe, 04/16 (avril 2016)
[article]
Titre : Methods for measuring pain in laboratory animals. Type de document : texte imprimé Auteurs : Dustin M. Graham Année de publication : 2016 Article en page(s) : p. 23-25 Langues : Anglais (eng) Mots-clés : Animals Animals, Laboratory* Behavior, Animal Facial Expression Movement/physiology Nociception Pain/physiopathology Pain Measurement/methods* Résumé : Pain is one of the most important variables that members of the lab animal science community try to control and minimize, and it is a critical topic of research in clinical and basic sciences. Objective measurements of pain severity, especially in non-verbal animals that are used as disease models, can be difficult to obtain, but several developments in behavioral neuroscience are making the measurement of pain more consistent, automated and accurate. Permalink : ./index.php?lvl=notice_display&id=76497
in LabAnimal-Europe > 04/16 (avril 2016) . - p. 23-25[article] Methods for measuring pain in laboratory animals. [texte imprimé] / Dustin M. Graham . - 2016 . - p. 23-25.
Langues : Anglais (eng)
in LabAnimal-Europe > 04/16 (avril 2016) . - p. 23-25
Mots-clés : Animals Animals, Laboratory* Behavior, Animal Facial Expression Movement/physiology Nociception Pain/physiopathology Pain Measurement/methods* Résumé : Pain is one of the most important variables that members of the lab animal science community try to control and minimize, and it is a critical topic of research in clinical and basic sciences. Objective measurements of pain severity, especially in non-verbal animals that are used as disease models, can be difficult to obtain, but several developments in behavioral neuroscience are making the measurement of pain more consistent, automated and accurate. Permalink : ./index.php?lvl=notice_display&id=76497 Réservation
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DisponibleBlood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus) / Wendy R. Williams in LabAnimal-Europe, 02/16 (février 2016)
[article]
Titre : Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus) Type de document : texte imprimé Auteurs : Wendy R. Williams, Auteur Année de publication : 2016 Article en page(s) : p. 10-17 Langues : Anglais (eng) Mots-clés : Anesthetics/pharmacology* Anesthetics, Combined/pharmacology Animals Animals, Laboratory Blood Cell Count/veterinary Blood Chemical Analysis/veterinary* Female Guinea Pigs/blood* Isoflurane/pharmacology* Ketamine/pharmacology* Liver/enzymology Xylazine/pharmacology* Anesthetics Anesthetics, Combined Xylazine Ketamine Isoflurane Résumé : Abstract
The guinea pig is a common animal model that is used in biomedical research to study a variety of systems, including hormonal and immunological responses, pulmonary physiology, corticosteroid response and others. However, because guinea pigs are evolutionarily a prey species, they do not readily show behavioral signs of disease, which can make it difficult to detect illness in a laboratory setting. Minimally invasive blood tests, such as complete blood counts and plasma biochemistry assays, are useful in both human and veterinary medicine as an initial diagnostic technique to rule in or rule out systemic illness. In guinea pigs, phlebotomy for such tests often requires that the animals be anesthetized first. The authors evaluated hematological and plasma biochemical effects of two anesthetic agents that are commonly used with guinea pigs in a research setting: isoflurane and a combination of ketamine and xylazine. Hematological and plasma biochemical parameters were significantly different when guinea pigs were under either anesthetic, compared to when they were unanesthetized. Plasma proteins, liver enzymes, white blood cells and red blood cells appeared to be significantly altered by both anesthetics, and hematological and plasma biochemical differences were greater when guinea pigs were anesthetized with the combination of ketamine and xylazine than when they were anesthetized with isoflurane. Overall these results indicate that both anesthetics can significantly influence hematological and plasma biochemical parameters in guinea pigs.Permalink : ./index.php?lvl=notice_display&id=66491
in LabAnimal-Europe > 02/16 (février 2016) . - p. 10-17[article] Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus) [texte imprimé] / Wendy R. Williams, Auteur . - 2016 . - p. 10-17.
Langues : Anglais (eng)
in LabAnimal-Europe > 02/16 (février 2016) . - p. 10-17
Mots-clés : Anesthetics/pharmacology* Anesthetics, Combined/pharmacology Animals Animals, Laboratory Blood Cell Count/veterinary Blood Chemical Analysis/veterinary* Female Guinea Pigs/blood* Isoflurane/pharmacology* Ketamine/pharmacology* Liver/enzymology Xylazine/pharmacology* Anesthetics Anesthetics, Combined Xylazine Ketamine Isoflurane Résumé : Abstract
The guinea pig is a common animal model that is used in biomedical research to study a variety of systems, including hormonal and immunological responses, pulmonary physiology, corticosteroid response and others. However, because guinea pigs are evolutionarily a prey species, they do not readily show behavioral signs of disease, which can make it difficult to detect illness in a laboratory setting. Minimally invasive blood tests, such as complete blood counts and plasma biochemistry assays, are useful in both human and veterinary medicine as an initial diagnostic technique to rule in or rule out systemic illness. In guinea pigs, phlebotomy for such tests often requires that the animals be anesthetized first. The authors evaluated hematological and plasma biochemical effects of two anesthetic agents that are commonly used with guinea pigs in a research setting: isoflurane and a combination of ketamine and xylazine. Hematological and plasma biochemical parameters were significantly different when guinea pigs were under either anesthetic, compared to when they were unanesthetized. Plasma proteins, liver enzymes, white blood cells and red blood cells appeared to be significantly altered by both anesthetics, and hematological and plasma biochemical differences were greater when guinea pigs were anesthetized with the combination of ketamine and xylazine than when they were anesthetized with isoflurane. Overall these results indicate that both anesthetics can significantly influence hematological and plasma biochemical parameters in guinea pigs.Permalink : ./index.php?lvl=notice_display&id=66491 Réservation
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DisponibleAntibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. / Joanna E. Fishback in LabAnimal-Europe, 03/16 (mars 2016)
[article]
Titre : Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Type de document : texte imprimé Auteurs : Joanna E. Fishback Année de publication : 2016 Article en page(s) : p. 10-14 Langues : Anglais (eng) Mots-clés : Adjuvants, Immunologic/administration & dosage Adjuvants, Immunologic/pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal/administration & dosage Anti-Inflammatory Agents, Non-Steroidal/pharmacology* Antibody Formation/drug effects Carbazoles/administration & dosage Carbazoles/pharmacology* Drug Therapy, Combination Female Freund's Adjuvant/administration & dosage Freund's Adjuvant/pharmacology* Rabbits/immunology* Adjuvants, Immunologic Anti-Inflammatory Agents, Non-Steroidal Carbazoles Freund's Adjuvant carprofen Résumé : Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA. Note de contenu : Erratum in Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Permalink : ./index.php?lvl=notice_display&id=76492
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 10-14[article] Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. [texte imprimé] / Joanna E. Fishback . - 2016 . - p. 10-14.
Langues : Anglais (eng)
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 10-14
Mots-clés : Adjuvants, Immunologic/administration & dosage Adjuvants, Immunologic/pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal/administration & dosage Anti-Inflammatory Agents, Non-Steroidal/pharmacology* Antibody Formation/drug effects Carbazoles/administration & dosage Carbazoles/pharmacology* Drug Therapy, Combination Female Freund's Adjuvant/administration & dosage Freund's Adjuvant/pharmacology* Rabbits/immunology* Adjuvants, Immunologic Anti-Inflammatory Agents, Non-Steroidal Carbazoles Freund's Adjuvant carprofen Résumé : Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA. Note de contenu : Erratum in Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Permalink : ./index.php?lvl=notice_display&id=76492 Réservation
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DisponibleCommon swine models of cardiovascular disease for research and training / Veronica Crisóstomo in LabAnimal-Europe, 03/16 (mars 2016)
[article]
Titre : Common swine models of cardiovascular disease for research and training Type de document : texte imprimé Auteurs : Veronica Crisóstomo Année de publication : 2016 Article en page(s) : p. 16-28 Langues : Anglais (eng) Mots-clés : Animals Biomedical Research/education Cardiovascular Diseases/diagnosis* Cardiovascular Diseases/etiology Cardiovascular Diseases/therapy* Disease Models, Animal Sus scrofa* Résumé : Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems. Permalink : ./index.php?lvl=notice_display&id=76493
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 16-28[article] Common swine models of cardiovascular disease for research and training [texte imprimé] / Veronica Crisóstomo . - 2016 . - p. 16-28.
Langues : Anglais (eng)
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 16-28
Mots-clés : Animals Biomedical Research/education Cardiovascular Diseases/diagnosis* Cardiovascular Diseases/etiology Cardiovascular Diseases/therapy* Disease Models, Animal Sus scrofa* Résumé : Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems. Permalink : ./index.php?lvl=notice_display&id=76493 Réservation
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DisponibleDevelopment and characterization of a new swine model of invasive pneumococcal pneumonia / Rosanel Amaro in LabAnimal, Vol. 21 N°12 (December 2021)
PermalinkKeeping an eye on the human-animal interface / Ellen P. Neff in LabAnimal, 04/21 (Avril 2021 vol. 21 N°4)
PermalinkLack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats / Alan Cowan in LabAnimal-Europe, 02/16 (février 2016)
PermalinkOral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems / Sina M Schalbetter in LabAnimal, 04/21 (Avril 2021 vol. 21 N°4)
PermalinkPercutaneous microembolization of the left coronary artery to model ischemic heart disease in rats / Allard Wagenaar in LabAnimal-Europe, 02/16 (février 2016)
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