[article] 
inActa Orthopaedica Belgica > Vol.87/2 (Juin 2021) . - p. 321-326

Titre :	The impact of direct oral anti-coagulants on hip fracture management : a systematic review and meta-analysis
Type de document :	texte imprimé
Auteurs :	Samuel Holmes ; Sarmad Bahnam
Année de publication :	2021
Article en page(s) :	p. 321-326
Note générale :	https://doi.org/10.52628/87.2.17
Langues :	Anglais (eng)
Mots-clés :	anti-coagulation  DOAC  NOAC  hip  fracture  NOF  neck of femur
Résumé :	Hip fractures are a common presentation in the elderly, a group who commonly have co-morbidities requiring the use of anticoagulants. Recently, direct oral anti-coagulants (DOAC) have become a popular method of anticoagulating patients. The primary aim of this review is to determine if the use of DOAC in elderly patients with hip fractures results in delays to theatre and/or an increased mortality risk. Major databases including Pubmed, MEDLINE and Embase were searched for relevant studies and the included studies reference lists were screened for further studies. A total of 6 studies were included in meta-analysis which was undertaken using RevMan software with 95% confidence interval (CI). Compared to control groups, patients who were anticoagulated with DOAC and required operative management of a hip fracture experienced a statistically significant delay to treatment. However independent analysis showed these patients did not experience an increased mortality risk when compared to the control group. While data is limited, treating clinicians should be comforted by these findings as operative manage- ment can be safely delayed to reduce the risk of intraoperative bleeding.
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[article] The impact of direct oral anti-coagulants on hip fracture management : a systematic review and meta-analysis [texte imprimé] / Samuel Holmes ; Sarmad Bahnam . - 2021 . - p. 321-326.
https://doi.org/10.52628/87.2.17
Langues : Anglais (eng)
in Acta Orthopaedica Belgica > Vol.87/2 (Juin 2021) . - p. 321-326

Mots-clés :	anti-coagulation  DOAC  NOAC  hip  fracture  NOF  neck of femur
Résumé :	Hip fractures are a common presentation in the elderly, a group who commonly have co-morbidities requiring the use of anticoagulants. Recently, direct oral anti-coagulants (DOAC) have become a popular method of anticoagulating patients. The primary aim of this review is to determine if the use of DOAC in elderly patients with hip fractures results in delays to theatre and/or an increased mortality risk. Major databases including Pubmed, MEDLINE and Embase were searched for relevant studies and the included studies reference lists were screened for further studies. A total of 6 studies were included in meta-analysis which was undertaken using RevMan software with 95% confidence interval (CI). Compared to control groups, patients who were anticoagulated with DOAC and required operative management of a hip fracture experienced a statistically significant delay to treatment. However independent analysis showed these patients did not experience an increased mortality risk when compared to the control group. While data is limited, treating clinicians should be comforted by these findings as operative manage- ment can be safely delayed to reduce the risk of intraoperative bleeding.
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