[article] 
inLabAnimal > 9/2020 (Septembre 2020) . - p. 4

Titre :	Development of a new preclinical model of Parkinson’s disease
Type de document :	texte imprimé
Auteurs :	Alexandra Le Bras
Année de publication :	2020
Article en page(s) :	p. 4
Langues :	Anglais (eng)
Résumé :	Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra and subsequent reduction of dopamine levels in the striatum, which results in motor impairment. Stem cell transplantation strategies aimed at replacing lost dopamine neurons have shown promising results in preclinical studies, but most of these studies have used toxin-induced models of PD, such as the 6-hydroxydopamine (6-OHDA) rodent model, which do not fully recapitulate human disease and might not predict the long-term effects of the host environment on the transplanted cells.
En ligne :	https://www.nature.com/articles/s41684-020-0612-3
Permalink :	./index.php?lvl=notice_display&id=90770

[article] Development of a new preclinical model of Parkinson’s disease [texte imprimé] / Alexandra Le Bras . - 2020 . - p. 4.
Langues : Anglais (eng)
in LabAnimal > 9/2020 (Septembre 2020) . - p. 4

Résumé :	Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra and subsequent reduction of dopamine levels in the striatum, which results in motor impairment. Stem cell transplantation strategies aimed at replacing lost dopamine neurons have shown promising results in preclinical studies, but most of these studies have used toxin-induced models of PD, such as the 6-hydroxydopamine (6-OHDA) rodent model, which do not fully recapitulate human disease and might not predict the long-term effects of the host environment on the transplanted cells.
En ligne :	https://www.nature.com/articles/s41684-020-0612-3
Permalink :	./index.php?lvl=notice_display&id=90770