Titre :	Added Value and Clinical Significance of NonlinearVariability Indices of Walking Stride Interval inNeurodegenerative Diseases
Type de document :	document électronique
Auteurs :	Frédéric Dierick ; Charlotte Vandevoorde ; Frédéric Chantraine ; Olivier White ; Fabien Buisseret
Année de publication :	2020
Note générale :	Cet article est une prépublication. doi: https://doi.org/10.1101/2020.01.31.20019455
Langues :	Anglais (eng)
Résumé :	Though self-paced walking is highly stereotyped, the stride interval fluctuates from one stride to the next around an average value with a measurable statistical variability. In clinical gait analysis, this variability is usually assessed with indices such the standard deviation or the coefficient of variation (CV). The aim of this study is to understand the added value that nonlinear indices of walking stride interval variability, such as Hurst exponent (H) and Minkowski fractal dimension (D), can provide in a clinical context and to suggest a clinical significance of these indices in the most common neurodegenerative diseases: Parkinson, Huntington, and amyotrophic lateral sclerosis. Although evidence have been accumulated that the stride interval organization at long range displays a more random, less autocorrelated, gait pattern in neurodegenerative diseases compared with young healthy individuals, it is today necessary to recompute CV, H, and D indices in a unified way and to take into account aging impact on these indices. In fact, computed nonlinear indices of variability are mainly dependent on stride interval time series length and algorithms used, making quantitative comparisons between different studies difficult or even impossible. Here, we recompute these indices from available stride interval time series, either coming from our lab or from online databases, or made available to us by the authors of previously conducted research. We confirm that both linear and nonlinear variability indices are relevant indicators of aging process and neurodegenerative diseases. CV is sensitive to aging process and pathology but does not allow to discriminate between specific neurodegenerative diseases. D shows no significative change in pathological groups. However, since H index is correlated with Hoehn & Yahr scores and significantly lowered in patients suffering from Huntington's disease, we recommend it as a relevant supplement to CV.
En ligne :	https://www.medrxiv.org/content/10.1101/2020.01.31.20019455v1.full.pdf
Permalink :	./index.php?lvl=notice_display&id=84497

Added Value and Clinical Significance of NonlinearVariability Indices of Walking Stride Interval inNeurodegenerative Diseases [document électronique] / Frédéric Dierick ; Charlotte Vandevoorde ; Frédéric Chantraine ; Olivier White ; Fabien Buisseret . - 2020.
Cet article est une prépublication.
doi: https://doi.org/10.1101/2020.01.31.20019455
Langues : Anglais (eng)

Résumé :	Though self-paced walking is highly stereotyped, the stride interval fluctuates from one stride to the next around an average value with a measurable statistical variability. In clinical gait analysis, this variability is usually assessed with indices such the standard deviation or the coefficient of variation (CV). The aim of this study is to understand the added value that nonlinear indices of walking stride interval variability, such as Hurst exponent (H) and Minkowski fractal dimension (D), can provide in a clinical context and to suggest a clinical significance of these indices in the most common neurodegenerative diseases: Parkinson, Huntington, and amyotrophic lateral sclerosis. Although evidence have been accumulated that the stride interval organization at long range displays a more random, less autocorrelated, gait pattern in neurodegenerative diseases compared with young healthy individuals, it is today necessary to recompute CV, H, and D indices in a unified way and to take into account aging impact on these indices. In fact, computed nonlinear indices of variability are mainly dependent on stride interval time series length and algorithms used, making quantitative comparisons between different studies difficult or even impossible. Here, we recompute these indices from available stride interval time series, either coming from our lab or from online databases, or made available to us by the authors of previously conducted research. We confirm that both linear and nonlinear variability indices are relevant indicators of aging process and neurodegenerative diseases. CV is sensitive to aging process and pathology but does not allow to discriminate between specific neurodegenerative diseases. D shows no significative change in pathological groups. However, since H index is correlated with Hoehn & Yahr scores and significantly lowered in patients suffering from Huntington's disease, we recommend it as a relevant supplement to CV.
En ligne :	https://www.medrxiv.org/content/10.1101/2020.01.31.20019455v1.full.pdf
Permalink :	./index.php?lvl=notice_display&id=84497