Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: a behavioral and molecular analysis / Indra A. Van Assche in LabAnimal, Vol.22 N°12 (décembre 2022)

Public ISBD [article]  inLabAnimal > Vol.22 N°12 (décembre 2022) . - p. 6-17 Titre : Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: a behavioral and molecular analysis Type de document : texte imprimé Auteurs : Indra A. Van Assche ; Mc Stephen Padilla ; Olivia S. R. P. Stupart ; Amy L. Milton Année de publication : 2022 Article en page(s) : p. 6-17 Langues : Anglais (eng) Mots-clés : émotion  extinction  conditionnement de la peur  psychologie  stress post-traumatique  animaux  Traumatologie animale  Comportement animal Résumé : Post-traumatic stress disorder (PTSD) is a debilitating mental health condition for which current treatments have long-term efficacy in 50% of patients. There is a clear need for better understanding of the mechanisms underlying PTSD and the development of new treatment approaches. Analog trauma procedures in animals, such as the stress-enhanced fear learning (SEFL) procedure, can be used to produce behavioral and neurobiological changes that have validity in modeling PTSD. However, by necessity, the modeling of PTSD in animals requires them to potentially experience pain and suffering. Consistent with the ‘3Rs’ (reduction, refinement and replacement) of animal research, this study aimed to determine whether the SEFL procedure can be refined to reduce potential animal pain and suffering while retaining the same behavioral and neurobiological changes. Here we showed that PTSD-relevant changes could be produced in both behavior and the brain of rats that were group- rather than single-housed and that received lower-magnitude electric shocks in the ‘trauma analog’ session. We also varied the number of shock exposures in the trauma analog session, finding SEFL-susceptible and SEFL-resilient populations at all levels of shock exposure, but with greater levels of shock increasing the proportion of rats showing the SEFL-susceptible phenotype. These data demonstrate that the SEFL procedure can be used as an animal analog of PTSD with reduced potential pain and suffering to the animals and that variations in the procedure could be used to generate specific proportions of SEFL-susceptible and SEFL-resilient animals in future studies. Permalink : ./index.php?lvl=notice_display&id=107959 [article] Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: a behavioral and molecular analysis [texte imprimé] / Indra A. Van Assche ; Mc Stephen Padilla ; Olivia S. R. P. Stupart ; Amy L. Milton . - 2022 . - p. 6-17. Langues : Anglais (eng) in LabAnimal > Vol.22 N°12 (décembre 2022) . - p. 6-17 Mots-clés : émotion  extinction  conditionnement de la peur  psychologie  stress post-traumatique  animaux  Traumatologie animale  Comportement animal Résumé : Post-traumatic stress disorder (PTSD) is a debilitating mental health condition for which current treatments have long-term efficacy in 50% of patients. There is a clear need for better understanding of the mechanisms underlying PTSD and the development of new treatment approaches. Analog trauma procedures in animals, such as the stress-enhanced fear learning (SEFL) procedure, can be used to produce behavioral and neurobiological changes that have validity in modeling PTSD. However, by necessity, the modeling of PTSD in animals requires them to potentially experience pain and suffering. Consistent with the ‘3Rs’ (reduction, refinement and replacement) of animal research, this study aimed to determine whether the SEFL procedure can be refined to reduce potential animal pain and suffering while retaining the same behavioral and neurobiological changes. Here we showed that PTSD-relevant changes could be produced in both behavior and the brain of rats that were group- rather than single-housed and that received lower-magnitude electric shocks in the ‘trauma analog’ session. We also varied the number of shock exposures in the trauma analog session, finding SEFL-susceptible and SEFL-resilient populations at all levels of shock exposure, but with greater levels of shock increasing the proportion of rats showing the SEFL-susceptible phenotype. These data demonstrate that the SEFL procedure can be used as an animal analog of PTSD with reduced potential pain and suffering to the animals and that variations in the procedure could be used to generate specific proportions of SEFL-susceptible and SEFL-resilient animals in future studies. Permalink : ./index.php?lvl=notice_display&id=107959

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