The genomic landscape of canine diffuse large B-cell lymphoma identifies distinct subtypes with clinical and therapeutic implications / Diana Giannuzzi in LabAnimal, Vol.22 N°8 (août 2022)

Public ISBD [article]  inLabAnimal > Vol.22 N°8 (août 2022) . - p. 5-22 Titre : The genomic landscape of canine diffuse large B-cell lymphoma identifies distinct subtypes with clinical and therapeutic implications Type de document : texte imprimé Auteurs : Diana Giannuzzi ; Laura Marconato ; Antonella Fanelli ; Luca Licenziato ; Rafaella De Maria Année de publication : 2022 Article en page(s) : p. 5-22 Langues : Anglais (eng) Mots-clés : B-cell lymphoma  Cancer genomics Résumé : Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid neoplasm in dogs and in humans. It is characterized by a remarkable degree of clinical heterogeneity that is not completely elucidated by molecular data. This poses a major barrier to understanding the disease and its response to therapy, or when treating dogs with DLBCL within clinical trials. We performed an integrated analysis of exome (n = 77) and RNA sequencing (n = 43) data in a cohort of canine DLBCL to define the genetic landscape of this tumor. A wide range of signaling pathways and cellular processes were found in common with human DLBCL, but the frequencies of the most recurrently mutated genes (TRAF3, SETD2, POT1, TP53, MYC, FBXW7, DDX3X and TBL1XR1) differed. We developed a prognostic model integrating exonic variants and clinical and transcriptomic features to predict the outcome in dogs with DLBCL. These results comprehensively define the genetic drivers of canine DLBCL and can be prospectively utilized to identify new therapeutic opportunities. Permalink : ./index.php?lvl=notice_display&id=105021 [article] The genomic landscape of canine diffuse large B-cell lymphoma identifies distinct subtypes with clinical and therapeutic implications [texte imprimé] / Diana Giannuzzi ; Laura Marconato ; Antonella Fanelli ; Luca Licenziato ; Rafaella De Maria . - 2022 . - p. 5-22. Langues : Anglais (eng) in LabAnimal > Vol.22 N°8 (août 2022) . - p. 5-22 Mots-clés : B-cell lymphoma  Cancer genomics Résumé : Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid neoplasm in dogs and in humans. It is characterized by a remarkable degree of clinical heterogeneity that is not completely elucidated by molecular data. This poses a major barrier to understanding the disease and its response to therapy, or when treating dogs with DLBCL within clinical trials. We performed an integrated analysis of exome (n = 77) and RNA sequencing (n = 43) data in a cohort of canine DLBCL to define the genetic landscape of this tumor. A wide range of signaling pathways and cellular processes were found in common with human DLBCL, but the frequencies of the most recurrently mutated genes (TRAF3, SETD2, POT1, TP53, MYC, FBXW7, DDX3X and TBL1XR1) differed. We developed a prognostic model integrating exonic variants and clinical and transcriptomic features to predict the outcome in dogs with DLBCL. These results comprehensively define the genetic drivers of canine DLBCL and can be prospectively utilized to identify new therapeutic opportunities. Permalink : ./index.php?lvl=notice_display&id=105021

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