(Re)organisation of the somatosensory system after early brain lesion : A lateralization index fMRI study / Jean-Michel Lemée in Annals of physical and rehabilitation medicine, Vol. 63, n°5 (Octobre 2020)

Public ISBD [article]  inAnnals of physical and rehabilitation medicine > Vol. 63, n°5 (Octobre 2020) . - p. 416-421 Titre : (Re)organisation of the somatosensory system after early brain lesion : A lateralization index fMRI study Type de document : texte imprimé Auteurs : Jean-Michel Lemée ; Eva Chinier ; Pauline Ali ; Matthieu Labriffe ; Aram Ter Minassian ; Mickael Dinomais Année de publication : 2020 Article en page(s) : p. 416-421 Note générale : doi.org/10.1016/j.rehab.2019.02.001 Langues : Anglais (eng) Mots-clés : Cerebral palsy  Sensory function  Plasticity  Functional MRI  Lateralization index  Brain lesion Résumé : Objective To evaluate the relationship between neural (re)organization of the somatosensory cortex and impairment of sensory function (2-point discrimination [2PD]) in individuals with unilateral cerebral palsy. Methods We included 21 individuals with unilateral cerebral palsy. 2PD thresholds were evaluated on thumb pads, and activation of the somatosensory cortex was recorded by functional MRI (fMRI) during passive movements of the affected hand. A lateralization index (LI) was calculated for the primary sensory (S1) and secondary sensory (S2) cortices and the correlation between the LI and 2PD thresholds was analysed. Results We found a significant negative correlation between the 2PD thresholds and the S2 LI (r = −0.5, one-tailed P-value = 0.01) and a trend towards a negative correlation with the S1 LI (r = −0.4, one-tailed P-value = 0.05). Conclusion High levels of activation in the contralesional hemisphere were associated with high levels of sensory impairment in individuals with unilateral cerebral palsy. The interhemispheric (re)organization of the somatosensory system may not effectively compensate for somatosensory impairment. Permalink : ./index.php?lvl=notice_display&id=91312 [article] (Re)organisation of the somatosensory system after early brain lesion : A lateralization index fMRI study [texte imprimé] / Jean-Michel Lemée ; Eva Chinier ; Pauline Ali ; Matthieu Labriffe ; Aram Ter Minassian ; Mickael Dinomais . - 2020 . - p. 416-421. doi.org/10.1016/j.rehab.2019.02.001 Langues : Anglais (eng) in Annals of physical and rehabilitation medicine > Vol. 63, n°5 (Octobre 2020) . - p. 416-421 Mots-clés : Cerebral palsy  Sensory function  Plasticity  Functional MRI  Lateralization index  Brain lesion Résumé : Objective To evaluate the relationship between neural (re)organization of the somatosensory cortex and impairment of sensory function (2-point discrimination [2PD]) in individuals with unilateral cerebral palsy. Methods We included 21 individuals with unilateral cerebral palsy. 2PD thresholds were evaluated on thumb pads, and activation of the somatosensory cortex was recorded by functional MRI (fMRI) during passive movements of the affected hand. A lateralization index (LI) was calculated for the primary sensory (S1) and secondary sensory (S2) cortices and the correlation between the LI and 2PD thresholds was analysed. Results We found a significant negative correlation between the 2PD thresholds and the S2 LI (r = −0.5, one-tailed P-value = 0.01) and a trend towards a negative correlation with the S1 LI (r = −0.4, one-tailed P-value = 0.05). Conclusion High levels of activation in the contralesional hemisphere were associated with high levels of sensory impairment in individuals with unilateral cerebral palsy. The interhemispheric (re)organization of the somatosensory system may not effectively compensate for somatosensory impairment. Permalink : ./index.php?lvl=notice_display&id=91312

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