Five-day course of paired associative stimulation fails to improve motor function in stroke patients / Mohamed Tarri in Annals of physical and rehabilitation medicine, Vol. 61, n°2 (Mars 2018)

Public ISBD [article]  inAnnals of physical and rehabilitation medicine > Vol. 61, n°2 (Mars 2018) . - p. 78-84 Titre : Five-day course of paired associative stimulation fails to improve motor function in stroke patients Type de document : texte imprimé Auteurs : Mohamed Tarri ; Nabila Brimhat ; David Gasq ; Benoît Lepage ; Isabelle Loubinoux ; Xavier De Boissezon ; P. Marque ; Evelyne Castel-Lacanal Année de publication : 2018 Article en page(s) : p. 78-84 Note générale : Doi : 10.1016/j.rehab.2017.11.002 Langues : Anglais (eng) Mots-clés : Paired associative stimulation  Stroke  Transcranial magnetic stimulation  Cortical plasticity, Recovery Résumé : Background Non-invasive brain stimulation has been studied as a therapeutic adjunct for upper-limb recovery in patients with stroke. One type of stimulation, paired associative stimulation (PAS), has effects on plasticity in both patients and healthy participants. Lasting several hours, these effects are reversible and topographically specific. Objective The goal was to investigate the presence of a lasting increase in motor cortex plasticity for extensor wrist muscles — extensor carpi radialis (ECR) — and an improvement in upper-limb function after 5 days of daily PAS in patients at the subacute post-stroke stage. Methods A total of 24 patients (mean [SD] age 50.1 [12.1] years, weeks since stroke 10.1 [5.3]) were included in a double-blind, placebo-controlled trial and randomly assigned to the PAS or sham group (n=13 and n=11). For the PAS group, patients underwent a 5-day course of electrical peripheral stimulation combined with magnetic cortical stimulation applied to the ECR muscle in a single daily session at 0.1Hz for 30min; patients with sham treatment received minimal cortical stimulation. Both patient groups underwent 2 hr of conventional physiotherapy. Variations in the motor evoked potential (MEP) surface area of the ECR muscle and Fugl–Meyer Assessment–Upper-Limb motor scores were analysed up to day 12. Results The 2 groups did not differ in electrophysiological or motor parameters. Repeated PAS sessions seemed to affect only patients with low initial cortical excitability. We found considerable variability in PAS effects between patients and across the sessions. Conclusion We failed to induce a lasting effect with PAS in the present study. PAS does not seem to be the main method for post-stroke brain stimulation. Perhaps recruitment of patients could be more selective, possibly targeting those with a wide altered ipsilesional corticomotor pathway. Permalink : ./index.php?lvl=notice_display&id=80450 [article] Five-day course of paired associative stimulation fails to improve motor function in stroke patients [texte imprimé] / Mohamed Tarri ; Nabila Brimhat ; David Gasq ; Benoît Lepage ; Isabelle Loubinoux ; Xavier De Boissezon ; P. Marque ; Evelyne Castel-Lacanal . - 2018 . - p. 78-84. Doi : 10.1016/j.rehab.2017.11.002 Langues : Anglais (eng) in Annals of physical and rehabilitation medicine > Vol. 61, n°2 (Mars 2018) . - p. 78-84 Mots-clés : Paired associative stimulation  Stroke  Transcranial magnetic stimulation  Cortical plasticity, Recovery Résumé : Background Non-invasive brain stimulation has been studied as a therapeutic adjunct for upper-limb recovery in patients with stroke. One type of stimulation, paired associative stimulation (PAS), has effects on plasticity in both patients and healthy participants. Lasting several hours, these effects are reversible and topographically specific. Objective The goal was to investigate the presence of a lasting increase in motor cortex plasticity for extensor wrist muscles — extensor carpi radialis (ECR) — and an improvement in upper-limb function after 5 days of daily PAS in patients at the subacute post-stroke stage. Methods A total of 24 patients (mean [SD] age 50.1 [12.1] years, weeks since stroke 10.1 [5.3]) were included in a double-blind, placebo-controlled trial and randomly assigned to the PAS or sham group (n=13 and n=11). For the PAS group, patients underwent a 5-day course of electrical peripheral stimulation combined with magnetic cortical stimulation applied to the ECR muscle in a single daily session at 0.1Hz for 30min; patients with sham treatment received minimal cortical stimulation. Both patient groups underwent 2 hr of conventional physiotherapy. Variations in the motor evoked potential (MEP) surface area of the ECR muscle and Fugl–Meyer Assessment–Upper-Limb motor scores were analysed up to day 12. Results The 2 groups did not differ in electrophysiological or motor parameters. Repeated PAS sessions seemed to affect only patients with low initial cortical excitability. We found considerable variability in PAS effects between patients and across the sessions. Conclusion We failed to induce a lasting effect with PAS in the present study. PAS does not seem to be the main method for post-stroke brain stimulation. Perhaps recruitment of patients could be more selective, possibly targeting those with a wide altered ipsilesional corticomotor pathway. Permalink : ./index.php?lvl=notice_display&id=80450

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