Longitudinal study of a NoGo-P3 event-related potential component following mild traumatic brain injury in adults / Gian Candrian in Annals of physical and rehabilitation medicine, Vol. 61, n°1 (Janvier 2018)

Public ISBD [article]  inAnnals of physical and rehabilitation medicine > Vol. 61, n°1 (Janvier 2018) . - p. 18-26 Titre : Longitudinal study of a NoGo-P3 event-related potential component following mild traumatic brain injury in adults Type de document : texte imprimé Auteurs : Gian Candrian ; Andreas Müller ; Patrizia Dall'Acqua ; Kyveli Kompatsiari ; Gian-Marco Baschera ; Ladislav Mica ; Hans-Peter Simmen ; Richard Glaab ; Javier Fandino ; Markus Schwendinger ; Christophe Meier ; Erika Jasmin Ulbrich ; Sönke Johannes Année de publication : 2018 Article en page(s) : p. 18-26 Note générale : Doi : 10.1016/j.rehab.2017.07.246 Langues : Anglais (eng) Mots-clés : Mild traumatic brain injury  Event-related potentials  Independent component analysis  Longitudinal Résumé : Background Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls. Methods We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis. Results Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury. Furthermore, mixed ANOVA revealed a significant time by group interaction (P<0.05), so the effect of time differed for symptomatic MTBI patients and healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3 months post-injury and were comparable to those of controls from 3 months to 1 year post-injury. However, amplitudes for 3 MTBI patients with particularly severe complaints 1 year post-injury did not normalize and were lower than those for the remaining MTBI sample (P<0.05). Conclusions Selected event-related potentials can be used as a sensitive and objective tool to illustrate the cognitive consequences of and recovery after MTBI. Permalink : ./index.php?lvl=notice_display&id=80435 [article] Longitudinal study of a NoGo-P3 event-related potential component following mild traumatic brain injury in adults [texte imprimé] / Gian Candrian ; Andreas Müller ; Patrizia Dall'Acqua ; Kyveli Kompatsiari ; Gian-Marco Baschera ; Ladislav Mica ; Hans-Peter Simmen ; Richard Glaab ; Javier Fandino ; Markus Schwendinger ; Christophe Meier ; Erika Jasmin Ulbrich ; Sönke Johannes . - 2018 . - p. 18-26. Doi : 10.1016/j.rehab.2017.07.246 Langues : Anglais (eng) in Annals of physical and rehabilitation medicine > Vol. 61, n°1 (Janvier 2018) . - p. 18-26 Mots-clés : Mild traumatic brain injury  Event-related potentials  Independent component analysis  Longitudinal Résumé : Background Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls. Methods We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis. Results Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury. Furthermore, mixed ANOVA revealed a significant time by group interaction (P<0.05), so the effect of time differed for symptomatic MTBI patients and healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3 months post-injury and were comparable to those of controls from 3 months to 1 year post-injury. However, amplitudes for 3 MTBI patients with particularly severe complaints 1 year post-injury did not normalize and were lower than those for the remaining MTBI sample (P<0.05). Conclusions Selected event-related potentials can be used as a sensitive and objective tool to illustrate the cognitive consequences of and recovery after MTBI. Permalink : ./index.php?lvl=notice_display&id=80435

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