Detection of mouse viruses in patient-derived xenografts / Alexandra Le Bras in LabAnimal, 06/21 (June 2021 N°6)  

Public ISBD [article]  inLabAnimal > 06/21 (June 2021 N°6) . - p. 6-7 Titre : Detection of mouse viruses in patient-derived xenografts Type de document : texte imprimé Auteurs : Alexandra Le Bras Année de publication : 2021 Article en page(s) : p. 6-7 Note générale : DOI: 10.1038/s41684-021-00761-8 Langues : Anglais (eng) Mots-clés : Animals  Disease Models, Animal  Heterografts  Mice  Viruses En ligne : https://www.nature.com/articles/s41684-021-00761-8 Permalink : ./index.php?lvl=notice_display&id=94505 [article] Detection of mouse viruses in patient-derived xenografts [texte imprimé] / Alexandra Le Bras . - 2021 . - p. 6-7. DOI: 10.1038/s41684-021-00761-8 Langues : Anglais (eng) in LabAnimal > 06/21 (June 2021 N°6) . - p. 6-7 Mots-clés : Animals  Disease Models, Animal  Heterografts  Mice  Viruses En ligne : https://www.nature.com/articles/s41684-021-00761-8 Permalink : ./index.php?lvl=notice_display&id=94505

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Development of a new preclinical model of Parkinson’s disease / Alexandra Le Bras in LabAnimal, 9/2020 (Septembre 2020)  

Public ISBD [article]  inLabAnimal > 9/2020 (Septembre 2020) . - p. 4 Titre : Development of a new preclinical model of Parkinson’s disease Type de document : texte imprimé Auteurs : Alexandra Le Bras Année de publication : 2020 Article en page(s) : p. 4 Langues : Anglais (eng) Résumé : Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra and subsequent reduction of dopamine levels in the striatum, which results in motor impairment. Stem cell transplantation strategies aimed at replacing lost dopamine neurons have shown promising results in preclinical studies, but most of these studies have used toxin-induced models of PD, such as the 6-hydroxydopamine (6-OHDA) rodent model, which do not fully recapitulate human disease and might not predict the long-term effects of the host environment on the transplanted cells. En ligne : https://www.nature.com/articles/s41684-020-0612-3 Permalink : ./index.php?lvl=notice_display&id=90770 [article] Development of a new preclinical model of Parkinson’s disease [texte imprimé] / Alexandra Le Bras . - 2020 . - p. 4. Langues : Anglais (eng) in LabAnimal > 9/2020 (Septembre 2020) . - p. 4 Résumé : Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra and subsequent reduction of dopamine levels in the striatum, which results in motor impairment. Stem cell transplantation strategies aimed at replacing lost dopamine neurons have shown promising results in preclinical studies, but most of these studies have used toxin-induced models of PD, such as the 6-hydroxydopamine (6-OHDA) rodent model, which do not fully recapitulate human disease and might not predict the long-term effects of the host environment on the transplanted cells. En ligne : https://www.nature.com/articles/s41684-020-0612-3 Permalink : ./index.php?lvl=notice_display&id=90770

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Gene-edited SHANK-3 mutant macaques display autism behavior / Alexandra Le Bras in LabAnimal, 09/19 (septembre 2019)  

Public ISBD [article]  inLabAnimal > 09/19 (septembre 2019) . - p. 10 Titre : Gene-edited SHANK-3 mutant macaques display autism behavior Type de document : texte imprimé Auteurs : Alexandra Le Bras Année de publication : 2019 Article en page(s) : p. 10 Langues : Anglais (eng) Résumé : Mutations in SHANK-3 — a gene encoding a synaptic scaffolding protein involved in the formation and maturation of excitatory synapses — are a major cause of Phelan-McDermid syndrome (PMS), an autism spectrum disorder (ASD) with symptoms that include intellectual disability, autistic behaviors, low muscle tone, and delayed or absent speech. En ligne : https://www.nature.com/articles/s41684-019-0366-y Permalink : ./index.php?lvl=notice_display&id=80093 [article] Gene-edited SHANK-3 mutant macaques display autism behavior [texte imprimé] / Alexandra Le Bras . - 2019 . - p. 10. Langues : Anglais (eng) in LabAnimal > 09/19 (septembre 2019) . - p. 10 Résumé : Mutations in SHANK-3 — a gene encoding a synaptic scaffolding protein involved in the formation and maturation of excitatory synapses — are a major cause of Phelan-McDermid syndrome (PMS), an autism spectrum disorder (ASD) with symptoms that include intellectual disability, autistic behaviors, low muscle tone, and delayed or absent speech. En ligne : https://www.nature.com/articles/s41684-019-0366-y Permalink : ./index.php?lvl=notice_display&id=80093

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Protein aggregation contributes to aging in C. elegans / Alexandra Le Bras in LabAnimal, 08/19 (août 2019)  

Public ISBD [article]  inLabAnimal > 08/19 (août 2019) . - p. 8 Titre : Protein aggregation contributes to aging in C. elegans Type de document : texte imprimé Auteurs : Alexandra Le Bras Année de publication : 2019 Article en page(s) : p. 8 Langues : Anglais (eng) En ligne : https://www.nature.com/articles/s41684-019-0335-5 Permalink : ./index.php?lvl=notice_display&id=80087 [article] Protein aggregation contributes to aging in C. elegans [texte imprimé] / Alexandra Le Bras . - 2019 . - p. 8. Langues : Anglais (eng) in LabAnimal > 08/19 (août 2019) . - p. 8 En ligne : https://www.nature.com/articles/s41684-019-0335-5 Permalink : ./index.php?lvl=notice_display&id=80087

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A systems biology approach to understand the effects of diet on lifespan / Alexandra Le Bras in LabAnimal, 10/2020 (Octobre 2020)  

Public ISBD [article]  inLabAnimal > 10/2020 (Octobre 2020) . - p. 4 Titre : A systems biology approach to understand the effects of diet on lifespan Type de document : texte imprimé Auteurs : Alexandra Le Bras Année de publication : 2020 Article en page(s) : p. 4 Note générale : DOI : https://doi.org/10.1038/s41684-020-0632-z Langues : Anglais (eng) Résumé : Dietary restriction (DR), which refers to a reduction in food intake without malnutrition, effectively prolongs lifespan in various species. However, several studies in rodents and Drosophila have shown that this effect is not universal and DR response can vary between strains and genotypes. To identify the mechanisms underlying this variation, a team of investigators led by Daniel Promislow from University of Washington exposed 178 inbred Drosophila melanogaster lines to either a DR or ad libitum (AL) diet. By comparing lifespan response to DR in the different strains and integrating genomic and metabolomic data, the team was able to identify several gene–metabolite networks involved in DR response variation. En ligne : https://www.nature.com/articles/s41684-020-0632-z Permalink : ./index.php?lvl=notice_display&id=90500 [article] A systems biology approach to understand the effects of diet on lifespan [texte imprimé] / Alexandra Le Bras . - 2020 . - p. 4. DOI : https://doi.org/10.1038/s41684-020-0632-z Langues : Anglais (eng) in LabAnimal > 10/2020 (Octobre 2020) . - p. 4 Résumé : Dietary restriction (DR), which refers to a reduction in food intake without malnutrition, effectively prolongs lifespan in various species. However, several studies in rodents and Drosophila have shown that this effect is not universal and DR response can vary between strains and genotypes. To identify the mechanisms underlying this variation, a team of investigators led by Daniel Promislow from University of Washington exposed 178 inbred Drosophila melanogaster lines to either a DR or ad libitum (AL) diet. By comparing lifespan response to DR in the different strains and integrating genomic and metabolomic data, the team was able to identify several gene–metabolite networks involved in DR response variation. En ligne : https://www.nature.com/articles/s41684-020-0632-z Permalink : ./index.php?lvl=notice_display&id=90500

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