A critical appraisal of open- and closed-chest models of experimental myocardial ischemia / Sofoklis Mitsos in LabAnimal-Europe, 6/09 (Juin 2009)

Public ISBD [article]  inLabAnimal-Europe > 6/09 (Juin 2009) . - p. 34-47 Titre : A critical appraisal of open- and closed-chest models of experimental myocardial ischemia Type de document : texte imprimé Auteurs : Sofoklis Mitsos Année de publication : 2009 Article en page(s) : p. 34-47 Langues : Anglais (eng) Résumé : Myocardial ischemia is one of the most extensively studied topics in modern cardiovascular research. Early investigators first reported experimental myocardial ischemia (EMI) in 1862. The open-chest (surgical) approach is a well-developed model of EMI that enables researchers to directly access and observe the heart. With this approach, EMI is generally induced by surgical ligation of a coronary artery. A drawback of the open-chest model is the need for major surgery, which can result in local and systemic side effects. Alternative closed-chest models of EMI have been developed; most of these models involve endovascular catheterization with coronary artery embolization or thrombosis. Closed-chest techniques eliminate the need for invasive surgery, and the resultant model is more physiologically similar to clinical myocardial ischemia than is EMI produced by artery ligation. The authors present a review of open- and closed-chest models of EMI and discuss the advantages and disadvantages of each approach. Permalink : ./index.php?lvl=notice_display&id=76441 [article] A critical appraisal of open- and closed-chest models of experimental myocardial ischemia [texte imprimé] / Sofoklis Mitsos . - 2009 . - p. 34-47. Langues : Anglais (eng) in LabAnimal-Europe > 6/09 (Juin 2009) . - p. 34-47 Résumé : Myocardial ischemia is one of the most extensively studied topics in modern cardiovascular research. Early investigators first reported experimental myocardial ischemia (EMI) in 1862. The open-chest (surgical) approach is a well-developed model of EMI that enables researchers to directly access and observe the heart. With this approach, EMI is generally induced by surgical ligation of a coronary artery. A drawback of the open-chest model is the need for major surgery, which can result in local and systemic side effects. Alternative closed-chest models of EMI have been developed; most of these models involve endovascular catheterization with coronary artery embolization or thrombosis. Closed-chest techniques eliminate the need for invasive surgery, and the resultant model is more physiologically similar to clinical myocardial ischemia than is EMI produced by artery ligation. The authors present a review of open- and closed-chest models of EMI and discuss the advantages and disadvantages of each approach. Permalink : ./index.php?lvl=notice_display&id=76441

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