Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus) / Wendy R. Williams in LabAnimal-Europe, 02/16 (février 2016)

Public ISBD [article]  inLabAnimal-Europe > 02/16 (février 2016) . - p. 10-17 Titre : Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus) Type de document : texte imprimé Auteurs : Wendy R. Williams, Auteur Année de publication : 2016 Article en page(s) : p. 10-17 Langues : Anglais (eng) Mots-clés : Anesthetics/pharmacology*  Anesthetics, Combined/pharmacology  Animals  Animals, Laboratory  Blood Cell Count/veterinary  Blood Chemical Analysis/veterinary*  Female  Guinea Pigs/blood*  Isoflurane/pharmacology*  Ketamine/pharmacology*  Liver/enzymology  Xylazine/pharmacology*  Anesthetics  Anesthetics, Combined  Xylazine  Ketamine  Isoflurane Résumé : Abstract The guinea pig is a common animal model that is used in biomedical research to study a variety of systems, including hormonal and immunological responses, pulmonary physiology, corticosteroid response and others. However, because guinea pigs are evolutionarily a prey species, they do not readily show behavioral signs of disease, which can make it difficult to detect illness in a laboratory setting. Minimally invasive blood tests, such as complete blood counts and plasma biochemistry assays, are useful in both human and veterinary medicine as an initial diagnostic technique to rule in or rule out systemic illness. In guinea pigs, phlebotomy for such tests often requires that the animals be anesthetized first. The authors evaluated hematological and plasma biochemical effects of two anesthetic agents that are commonly used with guinea pigs in a research setting: isoflurane and a combination of ketamine and xylazine. Hematological and plasma biochemical parameters were significantly different when guinea pigs were under either anesthetic, compared to when they were unanesthetized. Plasma proteins, liver enzymes, white blood cells and red blood cells appeared to be significantly altered by both anesthetics, and hematological and plasma biochemical differences were greater when guinea pigs were anesthetized with the combination of ketamine and xylazine than when they were anesthetized with isoflurane. Overall these results indicate that both anesthetics can significantly influence hematological and plasma biochemical parameters in guinea pigs. Permalink : ./index.php?lvl=notice_display&id=66491 [article] Blood profiles in unanesthetized and anesthetized guinea pigs (Cavia porcellus) [texte imprimé] / Wendy R. Williams, Auteur . - 2016 . - p. 10-17. Langues : Anglais (eng) in LabAnimal-Europe > 02/16 (février 2016) . - p. 10-17 Mots-clés : Anesthetics/pharmacology*  Anesthetics, Combined/pharmacology  Animals  Animals, Laboratory  Blood Cell Count/veterinary  Blood Chemical Analysis/veterinary*  Female  Guinea Pigs/blood*  Isoflurane/pharmacology*  Ketamine/pharmacology*  Liver/enzymology  Xylazine/pharmacology*  Anesthetics  Anesthetics, Combined  Xylazine  Ketamine  Isoflurane Résumé : Abstract The guinea pig is a common animal model that is used in biomedical research to study a variety of systems, including hormonal and immunological responses, pulmonary physiology, corticosteroid response and others. However, because guinea pigs are evolutionarily a prey species, they do not readily show behavioral signs of disease, which can make it difficult to detect illness in a laboratory setting. Minimally invasive blood tests, such as complete blood counts and plasma biochemistry assays, are useful in both human and veterinary medicine as an initial diagnostic technique to rule in or rule out systemic illness. In guinea pigs, phlebotomy for such tests often requires that the animals be anesthetized first. The authors evaluated hematological and plasma biochemical effects of two anesthetic agents that are commonly used with guinea pigs in a research setting: isoflurane and a combination of ketamine and xylazine. Hematological and plasma biochemical parameters were significantly different when guinea pigs were under either anesthetic, compared to when they were unanesthetized. Plasma proteins, liver enzymes, white blood cells and red blood cells appeared to be significantly altered by both anesthetics, and hematological and plasma biochemical differences were greater when guinea pigs were anesthetized with the combination of ketamine and xylazine than when they were anesthetized with isoflurane. Overall these results indicate that both anesthetics can significantly influence hematological and plasma biochemical parameters in guinea pigs. Permalink : ./index.php?lvl=notice_display&id=66491

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