[article] 
inAnnals of physical and rehabilitation medicine > Vol. 59, n° 3 (June 2016) . - p. 149-156

Titre :	Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches
Type de document :	texte imprimé
Auteurs :	Marta Anna Szychlinska, Auteur ; Rosalia Leonardi, Auteur ; Mohammed Al-Qahtani, Auteur
Année de publication :	2016
Article en page(s) :	p. 149-156
Langues :	Anglais (eng) Français (fre)
Mots-clés :	Inflammation  Arthrose  Articulation  Traumatisme  Inflammation,Pro-inflammatory cytokines,Lubricin,Osteoarthritis,Joint injury
Résumé :	Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief.
Permalink :	./index.php?lvl=notice_display&id=45204

[article] Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches [texte imprimé] / Marta Anna Szychlinska, Auteur ; Rosalia Leonardi, Auteur ; Mohammed Al-Qahtani, Auteur . - 2016 . - p. 149-156.
Langues : Anglais (eng) Français (fre)
in Annals of physical and rehabilitation medicine > Vol. 59, n° 3 (June 2016) . - p. 149-156

Mots-clés :	Inflammation  Arthrose  Articulation  Traumatisme  Inflammation,Pro-inflammatory cytokines,Lubricin,Osteoarthritis,Joint injury
Résumé :	Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief.
Permalink :	./index.php?lvl=notice_display&id=45204