[article]
| Titre : |
The Significance Of Interleukin-6 And Lactate In The Synovial Fluid For Diagnosing Native Septic Arthritis |
| Type de document : |
texte imprimé |
| Auteurs : |
Marcus LENSKI, Auteur ; Michael A. SCHERER, Auteur |
| Année de publication : |
2014 |
| Article en page(s) : |
p.18-25 |
| Langues : |
Français (fre) |
| Résumé : |
Aim of this study was to evaluate the role of synovial interleukin-6 and synovial lactate for predicting native septic arthritis. We analyzed retrospectively synovial fluid parameters (interleukin-6, total-protein, glucose, lactate, synovial-fluid-white-blood-cell-count) of 62 patients with culture-verified native septic arthritis and compared them to 57 patients with acute aseptic arthritis. Receiver-Operating-Characteristic-curves were calculated to determine the ‘Area-under-the-curves’ (AUC), the best thresholds and the corresponding likelihood-ratios. The best parameter for diagnosing septic arthritis was synovial lactate (AUC = 0.864, sensitivity = 74.5%, specificity = 87.2%), followed by synovial interleukin-6 (AUC = 0.803, sensitivity = 92.5%, specificity = 64.1%) and the synovial-fluid-white-blood-cell-count (AUC = 0.782, sensitivity = 71.2%, specificity = 84.9%). Synovial lactate levels above 10 mmol/l almost proofed septic arthritis (interval-Likelihood-Ratio = 20.4), synovial interleukin-6 levels lower than 7000 pg/ml almost ruled out infection (interval-Likelihood-Ratio = 0.12). If none of these thresholds are met, physicians should estimate disease probability by the simultaneous use of the interval-Likelihood-Ratios of synovial lactate, synovial interleukin-6 and synovial-fluid-white-blood-cell-count. |
| Permalink : |
./index.php?lvl=notice_display&id=33520 |
in Acta Orthopaedica Belgica > Vol 80/1 (Mars 2014) . - p.18-25
[article] The Significance Of Interleukin-6 And Lactate In The Synovial Fluid For Diagnosing Native Septic Arthritis [texte imprimé] / Marcus LENSKI, Auteur ; Michael A. SCHERER, Auteur . - 2014 . - p.18-25. Langues : Français ( fre) in Acta Orthopaedica Belgica > Vol 80/1 (Mars 2014) . - p.18-25
| Résumé : |
Aim of this study was to evaluate the role of synovial interleukin-6 and synovial lactate for predicting native septic arthritis. We analyzed retrospectively synovial fluid parameters (interleukin-6, total-protein, glucose, lactate, synovial-fluid-white-blood-cell-count) of 62 patients with culture-verified native septic arthritis and compared them to 57 patients with acute aseptic arthritis. Receiver-Operating-Characteristic-curves were calculated to determine the ‘Area-under-the-curves’ (AUC), the best thresholds and the corresponding likelihood-ratios. The best parameter for diagnosing septic arthritis was synovial lactate (AUC = 0.864, sensitivity = 74.5%, specificity = 87.2%), followed by synovial interleukin-6 (AUC = 0.803, sensitivity = 92.5%, specificity = 64.1%) and the synovial-fluid-white-blood-cell-count (AUC = 0.782, sensitivity = 71.2%, specificity = 84.9%). Synovial lactate levels above 10 mmol/l almost proofed septic arthritis (interval-Likelihood-Ratio = 20.4), synovial interleukin-6 levels lower than 7000 pg/ml almost ruled out infection (interval-Likelihood-Ratio = 0.12). If none of these thresholds are met, physicians should estimate disease probability by the simultaneous use of the interval-Likelihood-Ratios of synovial lactate, synovial interleukin-6 and synovial-fluid-white-blood-cell-count. |
| Permalink : |
./index.php?lvl=notice_display&id=33520 |
|  |
The Significance Of Interleukin-6 And Lactate In The Synovial Fluid For Diagnosing Native Septic Arthritis in Acta Orthopaedica Belgica, Vol 80/1 (Mars 2014)
