GABAergic drug use and global, cognitive, and motor functional outcomes after stroke / A.J.-P. Schwitzguébel in Annals of physical and rehabilitation medicine, Vol. 59, n°5-6 (December 2016)

Public ISBD [article]  inAnnals of physical and rehabilitation medicine > Vol. 59, n°5-6 (December 2016) . - p. 320-325 Titre : GABAergic drug use and global, cognitive, and motor functional outcomes after stroke Type de document : texte imprimé Auteurs : A.J.-P. Schwitzguébel ; Charles Benaïm ; Stefano Carda ; [et al...] Année de publication : 2016 Article en page(s) : p. 320-325 Langues : Français (fre) Mots-clés : Recovery  Rehabilitation  Stroke  GABA-A receptor agonists  Benzodiazepines  Minimal clinically important difference  Functional independence measure Résumé : Background In animal models and healthy volunteers, the use of GABA A receptor agonists (GABA-AGs) seem deleterious for functional recovery. The agents are widely used for subacute stroke, but their effect on functional recovery remains unclear. Objectives We aimed to evaluate the association between GABA-AG use and functional recovery after stroke. Methods We retrospectively recruited 434 survivors of subacute stroke admitted for inpatient rehabilitation between 2000 and 2013 in our institution (107 with and 327 without GABA-AG use). We used multivariate regression to assess the association of GABA-AG use and successful functional recovery, defined as reaching, between admission and discharge, the minimal clinically important difference (MCID) of 22 points on the global Functional Independence Measure (FIM). Secondary analyses were the associations of GABA-AG with cognitive and motor FIM MCID and constant GABA-AG exposure (24h/24 GABA-AG) with global, cognitive and motor FIM MCID. A new estimation of the MCID was performed with the standard error of measurement. Results Reaching the global FIM MCID was associated with GABA-AG use (adjusted odds ratio [aOR] 0.54 [95% CI 0.31–0.91], P=0.02) as well as 24h/24 GABA-AG use (aOR 0.25 [0.08–0.83]; P=0.02). Furthermore, GABA-AG and 24h/24 GABA-AG use was inversely but not always significantly associated with reaching the cognitive FIM MCID (aOR 0.56, P=0.07; aOR 0.26, P=0.06, respectively) and motor FIM MCID (aOR 0.51, P=0.07; aOR 0.13, P=0.01, respectively). The estimated MCID was 19 for global FIM, 4 for cognitive FIM, and 16 for motor FIM. Conclusions GABA-AG use is associated with not reaching successful functional recovery during stroke rehabilitation. Randomised trials are needed to formally establish the potential deleterious effect of GABA-AG use on functional recovery. Permalink : ./index.php?lvl=notice_display&id=47166 [article] GABAergic drug use and global, cognitive, and motor functional outcomes after stroke [texte imprimé] / A.J.-P. Schwitzguébel ; Charles Benaïm ; Stefano Carda ; [et al...] . - 2016 . - p. 320-325. Langues : Français (fre) in Annals of physical and rehabilitation medicine > Vol. 59, n°5-6 (December 2016) . - p. 320-325 Mots-clés : Recovery  Rehabilitation  Stroke  GABA-A receptor agonists  Benzodiazepines  Minimal clinically important difference  Functional independence measure Résumé : Background In animal models and healthy volunteers, the use of GABA A receptor agonists (GABA-AGs) seem deleterious for functional recovery. The agents are widely used for subacute stroke, but their effect on functional recovery remains unclear. Objectives We aimed to evaluate the association between GABA-AG use and functional recovery after stroke. Methods We retrospectively recruited 434 survivors of subacute stroke admitted for inpatient rehabilitation between 2000 and 2013 in our institution (107 with and 327 without GABA-AG use). We used multivariate regression to assess the association of GABA-AG use and successful functional recovery, defined as reaching, between admission and discharge, the minimal clinically important difference (MCID) of 22 points on the global Functional Independence Measure (FIM). Secondary analyses were the associations of GABA-AG with cognitive and motor FIM MCID and constant GABA-AG exposure (24h/24 GABA-AG) with global, cognitive and motor FIM MCID. A new estimation of the MCID was performed with the standard error of measurement. Results Reaching the global FIM MCID was associated with GABA-AG use (adjusted odds ratio [aOR] 0.54 [95% CI 0.31–0.91], P=0.02) as well as 24h/24 GABA-AG use (aOR 0.25 [0.08–0.83]; P=0.02). Furthermore, GABA-AG and 24h/24 GABA-AG use was inversely but not always significantly associated with reaching the cognitive FIM MCID (aOR 0.56, P=0.07; aOR 0.26, P=0.06, respectively) and motor FIM MCID (aOR 0.51, P=0.07; aOR 0.13, P=0.01, respectively). The estimated MCID was 19 for global FIM, 4 for cognitive FIM, and 16 for motor FIM. Conclusions GABA-AG use is associated with not reaching successful functional recovery during stroke rehabilitation. Randomised trials are needed to formally establish the potential deleterious effect of GABA-AG use on functional recovery. Permalink : ./index.php?lvl=notice_display&id=47166

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Document exclu du prêt - à consulter sur place Exclu du prêt

---

1 (1 - 1 / 1)