Effectiveness and safety of collagenase Clostridium histolyticum in Dupuytren’s disease : an observational study in Belgium / Frederik Verstreken in Acta Orthopaedica Belgica, Vol.82/2 (June 2016)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 397-404 Titre : Effectiveness and safety of collagenase Clostridium histolyticum in Dupuytren’s disease : an observational study in Belgium Type de document : texte imprimé Auteurs : Frederik Verstreken ; Ilse Degreef ; Arne Decramer ; [et al...] Année de publication : 2016 Article en page(s) : p. 397-404 Langues : Anglais (eng) Mots-clés : maladie de Dupuytren  collagène Résumé : Dupuytren’s disease is a connective tissue disorder leading to contractures. It can be treated surgically or through injections of collagenase Clostridium histolyticum (CCH). Patients with Dupuytren’s contracture (> 20°) and a palpable cord were included in this observational study, aiming to characterise the Belgian patient population and to assess the effectiveness and safety of CCH. Overall, 108 patients (114 joints) received at least one injection of CCH, and 104 patients completed the study. The percentages of joints achieving a degree of contracture of 5° or less, or a relative contracture reduction of at least 50% after the extension procedure were 64.9% and 90.1%, respectively. The mean number of injections per cord was 1.0. The Unité Rhumatologique des Affections de la Main score decreased from 29.4 ± 11.0 to 12.9 ± 6.3 (mean ± SD ; p < 0.0001). CCH was demonstrated to be effective, safe and able to increase quality of life. Permalink : ./index.php?lvl=notice_display&id=46251 [article] Effectiveness and safety of collagenase Clostridium histolyticum in Dupuytren’s disease : an observational study in Belgium [texte imprimé] / Frederik Verstreken ; Ilse Degreef ; Arne Decramer ; [et al...] . - 2016 . - p. 397-404. Langues : Anglais (eng) in Acta Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 397-404 Mots-clés : maladie de Dupuytren  collagène Résumé : Dupuytren’s disease is a connective tissue disorder leading to contractures. It can be treated surgically or through injections of collagenase Clostridium histolyticum (CCH). Patients with Dupuytren’s contracture (> 20°) and a palpable cord were included in this observational study, aiming to characterise the Belgian patient population and to assess the effectiveness and safety of CCH. Overall, 108 patients (114 joints) received at least one injection of CCH, and 104 patients completed the study. The percentages of joints achieving a degree of contracture of 5° or less, or a relative contracture reduction of at least 50% after the extension procedure were 64.9% and 90.1%, respectively. The mean number of injections per cord was 1.0. The Unité Rhumatologique des Affections de la Main score decreased from 29.4 ± 11.0 to 12.9 ± 6.3 (mean ± SD ; p < 0.0001). CCH was demonstrated to be effective, safe and able to increase quality of life. Permalink : ./index.php?lvl=notice_display&id=46251

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