Non-Metastatic Pelvic Ewing’s Sarcoma : oncologic outcomes and evaluation of prognostic factors / Asterios Dramis in Acta Orthopaedica Belgica, Vol.82/2 (June 2016)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 216-221 Titre : Non-Metastatic Pelvic Ewing’s Sarcoma : oncologic outcomes and evaluation of prognostic factors Type de document : texte imprimé Auteurs : Asterios Dramis ; Robert J. Grimer ; Konstantinos Malizos ; [et al...] Année de publication : 2016 Article en page(s) : p. 216-221 Langues : Anglais (eng) Mots-clés : sarcome d'Ewing  bassin  traitement Résumé : We are reporting our experience on patients with pelvic Ewing’s Sarcoma treated in our unit. We retrospectively reviewed a series of patients with non-metastatic pelvic Ewing’s sarcoma treated between 1977 and 2009. Patients were classified into three groups according to the local treatment received : Group 1. radiotherapy-chemo ; Group 2. surgery-chemo and Group 3. radiotherapy-surgery-chemo. Recurrence free and overall survival rates were calculated using the Kaplan-Meier method. Influence of various factors (age at diagnosis, gender, tumour site and size, chemotherapy response, surgical margins and type of treatment) on survival was assessed with a logistic regression model. A total of 85 patients were treated with a mean follow-up of 65.8 months and mean tumour volume of 435ml. The 5-year survival for all patients was 40.7% decreased to 36.2% at 10 years. A significant prognostic factor identified was chemotherapy response only. There was a trend for improved survival and local control rates for patients who had chemotherapy and surgery and the results were apparent for all tumours irrespective of size but not statistically significant. Currently, the optimal management of pelvic Ewing’s sarcoma is controversial but our study shows a trend for improved survival for patients treated with chemotherapy and surgery. Permalink : ./index.php?lvl=notice_display&id=46086 [article] Non-Metastatic Pelvic Ewing’s Sarcoma : oncologic outcomes and evaluation of prognostic factors [texte imprimé] / Asterios Dramis ; Robert J. Grimer ; Konstantinos Malizos ; [et al...] . - 2016 . - p. 216-221. Langues : Anglais (eng) in Acta Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 216-221 Mots-clés : sarcome d'Ewing  bassin  traitement Résumé : We are reporting our experience on patients with pelvic Ewing’s Sarcoma treated in our unit. We retrospectively reviewed a series of patients with non-metastatic pelvic Ewing’s sarcoma treated between 1977 and 2009. Patients were classified into three groups according to the local treatment received : Group 1. radiotherapy-chemo ; Group 2. surgery-chemo and Group 3. radiotherapy-surgery-chemo. Recurrence free and overall survival rates were calculated using the Kaplan-Meier method. Influence of various factors (age at diagnosis, gender, tumour site and size, chemotherapy response, surgical margins and type of treatment) on survival was assessed with a logistic regression model. A total of 85 patients were treated with a mean follow-up of 65.8 months and mean tumour volume of 435ml. The 5-year survival for all patients was 40.7% decreased to 36.2% at 10 years. A significant prognostic factor identified was chemotherapy response only. There was a trend for improved survival and local control rates for patients who had chemotherapy and surgery and the results were apparent for all tumours irrespective of size but not statistically significant. Currently, the optimal management of pelvic Ewing’s sarcoma is controversial but our study shows a trend for improved survival for patients treated with chemotherapy and surgery. Permalink : ./index.php?lvl=notice_display&id=46086

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