Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons / Sokratis Varitimidis in Acta Orthopaedica Belgica, Vol.82/2 (June 2016)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 179-188 Titre : Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons Type de document : texte imprimé Auteurs : Sokratis Varitimidis ; Zoe Dailiana ; Dimitrios Christou ; [et al...] Année de publication : 2016 Article en page(s) : p. 179-188 Langues : Anglais (eng) Mots-clés : coiffe des rotateurs  rupture Résumé : This study investigates the histological background of torn rotator cuff tendons, evaluates the stability of newly synthesized collagen by measuring the hydroxyproline content and attempts to correlate these findings with the clinical outcome after reconstruction of the rotator cuff. Sixty-one patients underwent reconstruction for a rotator cuff tear. They were evaluated preoperatively with the Constant-Murley score, MRI and ultrasound. Biopsy samples were taken from chronic rotator cuff tears and histological analysis was performed. Hydroxyprolin presence was evaluated in various tissues. Mean follow-up was 46 months. Histological analysis revealed collagen fragmentation and thinning (90.2% of patients), myxoid degeneration (88%), hyaline degeneration (50.8%), chondroid metaplasia (44.3%), calcification (24.7%), fatty infiltration (20.4%) and vascular proliferation (62.3%). Hydroxyproline was under-represented in newly synthesized collagen in 57% of patients. In the majority of the patients with a low hydroxyproline/collagen ratio the histological findings were abnormal. None of the findings was related to the clinical outcome with a statistical significance. Histological and biochemical findings reflected the poor quality of the tendon. The good clinical outcome did not depend on the histological or biochemical findings but rather on the meticulous surgical reconstruction and physical therapy. Permalink : ./index.php?lvl=notice_display&id=46081 [article] Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons [texte imprimé] / Sokratis Varitimidis ; Zoe Dailiana ; Dimitrios Christou ; [et al...] . - 2016 . - p. 179-188. Langues : Anglais (eng) in Acta Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 179-188 Mots-clés : coiffe des rotateurs  rupture Résumé : This study investigates the histological background of torn rotator cuff tendons, evaluates the stability of newly synthesized collagen by measuring the hydroxyproline content and attempts to correlate these findings with the clinical outcome after reconstruction of the rotator cuff. Sixty-one patients underwent reconstruction for a rotator cuff tear. They were evaluated preoperatively with the Constant-Murley score, MRI and ultrasound. Biopsy samples were taken from chronic rotator cuff tears and histological analysis was performed. Hydroxyprolin presence was evaluated in various tissues. Mean follow-up was 46 months. Histological analysis revealed collagen fragmentation and thinning (90.2% of patients), myxoid degeneration (88%), hyaline degeneration (50.8%), chondroid metaplasia (44.3%), calcification (24.7%), fatty infiltration (20.4%) and vascular proliferation (62.3%). Hydroxyproline was under-represented in newly synthesized collagen in 57% of patients. In the majority of the patients with a low hydroxyproline/collagen ratio the histological findings were abnormal. None of the findings was related to the clinical outcome with a statistical significance. Histological and biochemical findings reflected the poor quality of the tendon. The good clinical outcome did not depend on the histological or biochemical findings but rather on the meticulous surgical reconstruction and physical therapy. Permalink : ./index.php?lvl=notice_display&id=46081

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