Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments / Claire Vinatier in Annals of physical and rehabilitation medicine, Vol. 59, n° 3 (June 2016)

Public ISBD [article]  inAnnals of physical and rehabilitation medicine > Vol. 59, n° 3 (June 2016) . - p. 139-144 Titre : Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments Type de document : texte imprimé Auteurs : Claire Vinatier, Auteur ; Jérôme Guicheux, Auteur Année de publication : 2016 Article en page(s) : p. 139-144 Langues : Anglais (eng) Français (fre) Mots-clés : Tissu  Arthrose  Cellule  Biomatériau  Cartilage tissue engineering,Osteoarthritis,Stem cells,Biomaterials Résumé : Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative joint diseases such as osteoarthrtis. Because of the absence of vascularization, articular cartilage has low capacity for spontaneous repair. Today, and despite a large number of preclinical data, no therapy capable of restoring the healthy structure and function of damaged articular cartilage is clinically available. Tissue-engineering strategies involving the combination of cells, scaffolding biomaterials and bioactive agents have been of interest notably for the repair of damaged articular cartilage. During the last 30 years, cartilage tissue engineering has evolved from the treatment of focal lesions of articular cartilage to the development of strategies targeting the osteoarthritis process. In this review, we focus on the different aspects of tissue engineering applied to cartilage engineering. We first discuss cells, biomaterials and biological or environmental factors instrumental to the development of cartilage tissue engineering, then review the potential development of cartilage engineering strategies targeting new emerging pathogenic mechanisms of osteoarthritis. Permalink : ./index.php?lvl=notice_display&id=45207 [article] Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments [texte imprimé] / Claire Vinatier, Auteur ; Jérôme Guicheux, Auteur . - 2016 . - p. 139-144. Langues : Anglais (eng) Français (fre) in Annals of physical and rehabilitation medicine > Vol. 59, n° 3 (June 2016) . - p. 139-144 Mots-clés : Tissu  Arthrose  Cellule  Biomatériau  Cartilage tissue engineering,Osteoarthritis,Stem cells,Biomaterials Résumé : Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative joint diseases such as osteoarthrtis. Because of the absence of vascularization, articular cartilage has low capacity for spontaneous repair. Today, and despite a large number of preclinical data, no therapy capable of restoring the healthy structure and function of damaged articular cartilage is clinically available. Tissue-engineering strategies involving the combination of cells, scaffolding biomaterials and bioactive agents have been of interest notably for the repair of damaged articular cartilage. During the last 30 years, cartilage tissue engineering has evolved from the treatment of focal lesions of articular cartilage to the development of strategies targeting the osteoarthritis process. In this review, we focus on the different aspects of tissue engineering applied to cartilage engineering. We first discuss cells, biomaterials and biological or environmental factors instrumental to the development of cartilage tissue engineering, then review the potential development of cartilage engineering strategies targeting new emerging pathogenic mechanisms of osteoarthritis. Permalink : ./index.php?lvl=notice_display&id=45207

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