Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches / Marta Anna Szychlinska in Annals of physical and rehabilitation medicine, Vol. 59, n° 3 (June 2016)

Public ISBD [article]  inAnnals of physical and rehabilitation medicine > Vol. 59, n° 3 (June 2016) . - p. 149-156 Titre : Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches Type de document : texte imprimé Auteurs : Marta Anna Szychlinska, Auteur ; Rosalia Leonardi, Auteur ; Mohammed Al-Qahtani, Auteur Année de publication : 2016 Article en page(s) : p. 149-156 Langues : Anglais (eng) Français (fre) Mots-clés : Inflammation  Arthrose  Articulation  Traumatisme  Inflammation,Pro-inflammatory cytokines,Lubricin,Osteoarthritis,Joint injury Résumé : Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief. Permalink : ./index.php?lvl=notice_display&id=45204 [article] Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches [texte imprimé] / Marta Anna Szychlinska, Auteur ; Rosalia Leonardi, Auteur ; Mohammed Al-Qahtani, Auteur . - 2016 . - p. 149-156. Langues : Anglais (eng) Français (fre) in Annals of physical and rehabilitation medicine > Vol. 59, n° 3 (June 2016) . - p. 149-156 Mots-clés : Inflammation  Arthrose  Articulation  Traumatisme  Inflammation,Pro-inflammatory cytokines,Lubricin,Osteoarthritis,Joint injury Résumé : Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief. Permalink : ./index.php?lvl=notice_display&id=45204

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Document exclu du prêt - à consulter sur place Exclu du prêt

---

1 (1 - 1 / 1)