Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons / Sokratis Varitimidis in Acta Orthopaedica Belgica, Vol.82/2 (June 2016)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 179-188 Titre : Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons Type de document : texte imprimé Auteurs : Sokratis Varitimidis ; Zoe Dailiana ; Dimitrios Christou ; [et al...] Année de publication : 2016 Article en page(s) : p. 179-188 Langues : Anglais (eng) Mots-clés : coiffe des rotateurs  rupture Résumé : This study investigates the histological background of torn rotator cuff tendons, evaluates the stability of newly synthesized collagen by measuring the hydroxyproline content and attempts to correlate these findings with the clinical outcome after reconstruction of the rotator cuff. Sixty-one patients underwent reconstruction for a rotator cuff tear. They were evaluated preoperatively with the Constant-Murley score, MRI and ultrasound. Biopsy samples were taken from chronic rotator cuff tears and histological analysis was performed. Hydroxyprolin presence was evaluated in various tissues. Mean follow-up was 46 months. Histological analysis revealed collagen fragmentation and thinning (90.2% of patients), myxoid degeneration (88%), hyaline degeneration (50.8%), chondroid metaplasia (44.3%), calcification (24.7%), fatty infiltration (20.4%) and vascular proliferation (62.3%). Hydroxyproline was under-represented in newly synthesized collagen in 57% of patients. In the majority of the patients with a low hydroxyproline/collagen ratio the histological findings were abnormal. None of the findings was related to the clinical outcome with a statistical significance. Histological and biochemical findings reflected the poor quality of the tendon. The good clinical outcome did not depend on the histological or biochemical findings but rather on the meticulous surgical reconstruction and physical therapy. Permalink : ./index.php?lvl=notice_display&id=46081 [article] Histological and biochemical evidence related to the collagen quality in torn rotator cuff tendons [texte imprimé] / Sokratis Varitimidis ; Zoe Dailiana ; Dimitrios Christou ; [et al...] . - 2016 . - p. 179-188. Langues : Anglais (eng) in Acta Orthopaedica Belgica > Vol.82/2 (June 2016) . - p. 179-188 Mots-clés : coiffe des rotateurs  rupture Résumé : This study investigates the histological background of torn rotator cuff tendons, evaluates the stability of newly synthesized collagen by measuring the hydroxyproline content and attempts to correlate these findings with the clinical outcome after reconstruction of the rotator cuff. Sixty-one patients underwent reconstruction for a rotator cuff tear. They were evaluated preoperatively with the Constant-Murley score, MRI and ultrasound. Biopsy samples were taken from chronic rotator cuff tears and histological analysis was performed. Hydroxyprolin presence was evaluated in various tissues. Mean follow-up was 46 months. Histological analysis revealed collagen fragmentation and thinning (90.2% of patients), myxoid degeneration (88%), hyaline degeneration (50.8%), chondroid metaplasia (44.3%), calcification (24.7%), fatty infiltration (20.4%) and vascular proliferation (62.3%). Hydroxyproline was under-represented in newly synthesized collagen in 57% of patients. In the majority of the patients with a low hydroxyproline/collagen ratio the histological findings were abnormal. None of the findings was related to the clinical outcome with a statistical significance. Histological and biochemical findings reflected the poor quality of the tendon. The good clinical outcome did not depend on the histological or biochemical findings but rather on the meticulous surgical reconstruction and physical therapy. Permalink : ./index.php?lvl=notice_display&id=46081

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Operative management of humeral nonunions. Factors that influence the outcome / Antonios KOUTALOS in Acta Orthopaedica Belgica, Vol. 81/3 (Septembre 2015)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol. 81/3 (Septembre 2015) . - p.501-510 Titre : Operative management of humeral nonunions. Factors that influence the outcome Type de document : texte imprimé Auteurs : Antonios KOUTALOS, Auteur ; Sokratis Varitimidis, Auteur ; Zoe Dailiana, Auteur Année de publication : 2015 Article en page(s) : p.501-510 Langues : Anglais (eng) Mots-clés : Humeral nonunion  plate fixation  bone graft  infection  atrophic nonunion Résumé : The purpose of this study is to present the outcome of surgically treated humeral nonunions and find factors that affect the outcome. Fortytwo patients with humeral nonunions (30 shaft, 7 proximal and 5 distal) were reviewed in a prospective manner. Treatment was based on a specific algorithm. Demographics, time to union, range of motion, functional outcome and complications were recorded and analysed. Results: Mean follow-up was 78 months and mean time to union was 4.3 months. Infection was associated with delayed union of the pseudarthrosis, while range of motion was negatively affected by the location (proximal) and the AO type of the initial fracture. Complication rate was 17%. Conclusion: The surgical management of humeral nonunions yields a favourable outcome with reduced rate of complications. Infection prolonged healing time, while proximal location of the nonunion and the type B or C fracture according to AO/OTA classification adversely affected range of motion. Permalink : ./index.php?lvl=notice_display&id=40927 [article] Operative management of humeral nonunions. Factors that influence the outcome [texte imprimé] / Antonios KOUTALOS, Auteur ; Sokratis Varitimidis, Auteur ; Zoe Dailiana, Auteur . - 2015 . - p.501-510. Langues : Anglais (eng) in Acta Orthopaedica Belgica > Vol. 81/3 (Septembre 2015) . - p.501-510 Mots-clés : Humeral nonunion  plate fixation  bone graft  infection  atrophic nonunion Résumé : The purpose of this study is to present the outcome of surgically treated humeral nonunions and find factors that affect the outcome. Fortytwo patients with humeral nonunions (30 shaft, 7 proximal and 5 distal) were reviewed in a prospective manner. Treatment was based on a specific algorithm. Demographics, time to union, range of motion, functional outcome and complications were recorded and analysed. Results: Mean follow-up was 78 months and mean time to union was 4.3 months. Infection was associated with delayed union of the pseudarthrosis, while range of motion was negatively affected by the location (proximal) and the AO type of the initial fracture. Complication rate was 17%. Conclusion: The surgical management of humeral nonunions yields a favourable outcome with reduced rate of complications. Infection prolonged healing time, while proximal location of the nonunion and the type B or C fracture according to AO/OTA classification adversely affected range of motion. Permalink : ./index.php?lvl=notice_display&id=40927

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