Animal Models For Acquired Heterotopic Ossification / Joris ANTHONISSEN in Acta Orthopaedica Belgica, Vol 80/1 (Mars 2014)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol 80/1 (Mars 2014) . - p.2-10 Titre : Animal Models For Acquired Heterotopic Ossification Type de document : texte imprimé Auteurs : Joris ANTHONISSEN, Auteur ; Christian OSSENDORF, Auteur ; Ulrike RITZ, Auteur ; A HOFFMAN, Auteur ; Pol MARIA ROMMENS, Auteur Année de publication : 2014 Article en page(s) : p.2-10 Langues : Français (fre) Résumé : Heterotopic ossification (HO), the ectopic formation of bone in soft tissues, is a relevant musculoskeletal disorder that, by reduction of range of motion, may lead to significant impairment of quality of live. HO can either be acquired or hereditary. Acquired HO is seen most often after hip prosthetic surgery and pelvic trauma. In contrast, hereditary HO is commonly observed in the axial skeleton, but can affect every joint. Substantial effort has been directed towards understanding the pathophysiology and towards finding both, effective prophylactic and therapeutic treatments. Every improvement of the understanding of the pathophysiologic changes underlying HO as well as the rationale of prophylactic and therapeutic­ treatment regimens in the end, is based on the study of appropriate animal models. Although intriguing models of ‘genetic‘ HO have been developed recently, their relevance to acquired HO remains questionable. As there is still neither proper treatment nor reliable prophylaxis, animal models will remain important in the study of HO. Currently, there are 6 different animal models regularly used for the study of acquired HO. Some of these models can reflect a merely particular part of the disease. Hence, selection of the appropriate animal model for the study of HO is exceedingly important. The present paper reviews the history and major features of the different animal models of acquired HO, and reveals some of the insights gained through the study of animal models?; important biochemical and pathophysiological key features are highlighted. Clinical studies have proved indo­metacine, celecoxib and radiation therapy to be effective in reducing the occurrence of HO, but not always be able to prevent it. Permalink : ./index.php?lvl=notice_display&id=33518 [article] Animal Models For Acquired Heterotopic Ossification [texte imprimé] / Joris ANTHONISSEN, Auteur ; Christian OSSENDORF, Auteur ; Ulrike RITZ, Auteur ; A HOFFMAN, Auteur ; Pol MARIA ROMMENS, Auteur . - 2014 . - p.2-10. Langues : Français (fre) in Acta Orthopaedica Belgica > Vol 80/1 (Mars 2014) . - p.2-10 Résumé : Heterotopic ossification (HO), the ectopic formation of bone in soft tissues, is a relevant musculoskeletal disorder that, by reduction of range of motion, may lead to significant impairment of quality of live. HO can either be acquired or hereditary. Acquired HO is seen most often after hip prosthetic surgery and pelvic trauma. In contrast, hereditary HO is commonly observed in the axial skeleton, but can affect every joint. Substantial effort has been directed towards understanding the pathophysiology and towards finding both, effective prophylactic and therapeutic treatments. Every improvement of the understanding of the pathophysiologic changes underlying HO as well as the rationale of prophylactic and therapeutic­ treatment regimens in the end, is based on the study of appropriate animal models. Although intriguing models of ‘genetic‘ HO have been developed recently, their relevance to acquired HO remains questionable. As there is still neither proper treatment nor reliable prophylaxis, animal models will remain important in the study of HO. Currently, there are 6 different animal models regularly used for the study of acquired HO. Some of these models can reflect a merely particular part of the disease. Hence, selection of the appropriate animal model for the study of HO is exceedingly important. The present paper reviews the history and major features of the different animal models of acquired HO, and reveals some of the insights gained through the study of animal models?; important biochemical and pathophysiological key features are highlighted. Clinical studies have proved indo­metacine, celecoxib and radiation therapy to be effective in reducing the occurrence of HO, but not always be able to prevent it. Permalink : ./index.php?lvl=notice_display&id=33518

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The pathogenesis of heterotopic ossification after traumatic brain injury. A review of current literature / Joris ANTHONISSEN in Acta Orthopaedica Belgica, Vol. 86/3 (Septembre 2020)

Public ISBD [article]  inActa Orthopaedica Belgica > Vol. 86/3 (Septembre 2020) . - p. 369-377 Titre : The pathogenesis of heterotopic ossification after traumatic brain injury. A review of current literature Type de document : texte imprimé Auteurs : Joris ANTHONISSEN, Auteur Année de publication : 2020 Article en page(s) : p. 369-377 Langues : Anglais (eng) Résumé : Neurogenic heterotopic ossification (NHO), mostly defined as a benign process of formation of bone outside the skeletal system, after traumatic brain injury (TBI) is a musculoskeletal disorder that causes pain and reduces the range of motion, often leading to marked impairment of quality of life. The pathogenic factors that link the brain and bone and cause the formation of heterotopic bone are largely unknown. This article will try to summarize the current literature on the pathogenesis of NHO and accelerated fracture healing after TBI. The heterotopic formation of bone after TBI seems to be inducted by a complex interplay between local and systemic factors. For all different forms of HO, the same three conditions are required for the formation of ectopic bone : The presence of osteoprogenitor cells, a permissive environment, and a stimulating factor. The osteoprogenitor cells are thought to be of mesenchymal origin, however recent research suggests a possible neural origin. The permissive environment is created mainly by reactions to hypoxia and both local and sensory nerve inflammation. Many possible inducing factors have been described ; the endogenic route is thought to be the most dominant in the stimulation of HO formation after TBI. The pathogenesis of NHO remains largely unknown, recent research, however, has discovered interesting topics for further research and new possible targets in the prevention of NHO. Permalink : ./index.php?lvl=notice_display&id=92001 [article] The pathogenesis of heterotopic ossification after traumatic brain injury. A review of current literature [texte imprimé] / Joris ANTHONISSEN, Auteur . - 2020 . - p. 369-377. Langues : Anglais (eng) in Acta Orthopaedica Belgica > Vol. 86/3 (Septembre 2020) . - p. 369-377 Résumé : Neurogenic heterotopic ossification (NHO), mostly defined as a benign process of formation of bone outside the skeletal system, after traumatic brain injury (TBI) is a musculoskeletal disorder that causes pain and reduces the range of motion, often leading to marked impairment of quality of life. The pathogenic factors that link the brain and bone and cause the formation of heterotopic bone are largely unknown. This article will try to summarize the current literature on the pathogenesis of NHO and accelerated fracture healing after TBI. The heterotopic formation of bone after TBI seems to be inducted by a complex interplay between local and systemic factors. For all different forms of HO, the same three conditions are required for the formation of ectopic bone : The presence of osteoprogenitor cells, a permissive environment, and a stimulating factor. The osteoprogenitor cells are thought to be of mesenchymal origin, however recent research suggests a possible neural origin. The permissive environment is created mainly by reactions to hypoxia and both local and sensory nerve inflammation. Many possible inducing factors have been described ; the endogenic route is thought to be the most dominant in the stimulation of HO formation after TBI. The pathogenesis of NHO remains largely unknown, recent research, however, has discovered interesting topics for further research and new possible targets in the prevention of NHO. Permalink : ./index.php?lvl=notice_display&id=92001

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