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Translational science / Rebecca L. Walker in LabAnimal, Vol.22 N°2 (février 2022)

Public ISBD [article]  inLabAnimal > Vol.22 N°2 (février 2022) . - p. 6-24 Titre : Translational science : a survey of US bioimedical researchers' perspectives and practices Type de document : texte imprimé Auteurs : Rebecca L. Walker ; Katherine W Saylor ; Margaret Waltz ; Jill A. Fisher Année de publication : 2022 Article en page(s) : p. 6-24 Langues : Anglais (eng) Résumé : This national survey aimed to identify how biomedical researchers using vertebrate animals viewed issues of significance for translational science, including oversight and public engagement, and to analyze how researcher characteristics and animal model choice correlate with those views. Responses from 1,187 researchers showed awareness of, and concerns about, problems of translation, reproducibility and rigor. Surveyed scientists were nevertheless optimistic about the value of animal studies, were favorable about research oversight and reported openness with non-scientists in discussing their animal work. Differences in survey responses among researchers also point to diverse perspectives within the animal research community on these matters. Most significant was variability associated with the primary type of animal that surveyed scientists used in their work. Other significant divergence in opinion appeared on the basis of professional role factors, including the type of degree held, workplace setting, type of funding, experience on an institutional animal care and use committee and personal demographic characteristics of age and gender. Permalink : ./index.php?lvl=notice_display&id=101199 [article] Translational science : a survey of US bioimedical researchers' perspectives and practices [texte imprimé] / Rebecca L. Walker ; Katherine W Saylor ; Margaret Waltz ; Jill A. Fisher . - 2022 . - p. 6-24. Langues : Anglais (eng) in LabAnimal > Vol.22 N°2 (février 2022) . - p. 6-24 Résumé : This national survey aimed to identify how biomedical researchers using vertebrate animals viewed issues of significance for translational science, including oversight and public engagement, and to analyze how researcher characteristics and animal model choice correlate with those views. Responses from 1,187 researchers showed awareness of, and concerns about, problems of translation, reproducibility and rigor. Surveyed scientists were nevertheless optimistic about the value of animal studies, were favorable about research oversight and reported openness with non-scientists in discussing their animal work. Differences in survey responses among researchers also point to diverse perspectives within the animal research community on these matters. Most significant was variability associated with the primary type of animal that surveyed scientists used in their work. Other significant divergence in opinion appeared on the basis of professional role factors, including the type of degree held, workplace setting, type of funding, experience on an institutional animal care and use committee and personal demographic characteristics of age and gender. Permalink : ./index.php?lvl=notice_display&id=101199

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Assembly and operation of an easy-to-make portable device for facilitating mouse lateral tail-vein injection / Qi Wu in LabAnimal, Vol.22 N°2 (février 2022)

Public ISBD [article]  inLabAnimal > Vol.22 N°2 (février 2022) . - p. 25-35 Titre : Assembly and operation of an easy-to-make portable device for facilitating mouse lateral tail-vein injection Type de document : texte imprimé Auteurs : Qi Wu ; Zhen Xing ; Bin Chen Année de publication : 2022 Article en page(s) : p. 25-35 Langues : Anglais (eng) Résumé : Drug delivery by lateral tail-vein injection in mice is widely used in preclinical research, but the technique is laborious to perform because the tail vein is hardly visible and too small to be cannulated. Misinjections of test components can lead to defective or even false experiment results. We present a simple but useful injection-assistant device to visualize the tail vein of mice. The device consists of a light-emitting diode (LED) circuit and a finger component. The finger component consists of an open-looped ring to slide on the finger, a slot to accommodate the mouse’s tail and a lamp cage in which to set the LED lamp. Once the mouse’s tail has been illuminated, the tail vein can be clearly seen as a dark line along the bright background of the tail, which facilitates venipuncture and improves the success rate of tail-vein injection. If the protocol provided has been followed correctly, a robust tail-vein injection-assistant device can be set up in 3 h with low-cost components. Permalink : ./index.php?lvl=notice_display&id=101200 [article] Assembly and operation of an easy-to-make portable device for facilitating mouse lateral tail-vein injection [texte imprimé] / Qi Wu ; Zhen Xing ; Bin Chen . - 2022 . - p. 25-35. Langues : Anglais (eng) in LabAnimal > Vol.22 N°2 (février 2022) . - p. 25-35 Résumé : Drug delivery by lateral tail-vein injection in mice is widely used in preclinical research, but the technique is laborious to perform because the tail vein is hardly visible and too small to be cannulated. Misinjections of test components can lead to defective or even false experiment results. We present a simple but useful injection-assistant device to visualize the tail vein of mice. The device consists of a light-emitting diode (LED) circuit and a finger component. The finger component consists of an open-looped ring to slide on the finger, a slot to accommodate the mouse’s tail and a lamp cage in which to set the LED lamp. Once the mouse’s tail has been illuminated, the tail vein can be clearly seen as a dark line along the bright background of the tail, which facilitates venipuncture and improves the success rate of tail-vein injection. If the protocol provided has been followed correctly, a robust tail-vein injection-assistant device can be set up in 3 h with low-cost components. Permalink : ./index.php?lvl=notice_display&id=101200

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