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Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system / Mónica J. B. Amorim in LabAnimal, Vol. 21 N°11 (November 2021)  

Public ISBD [article]  inLabAnimal > Vol. 21 N°11 (November 2021) . - p. 8-19 Titre : Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system Type de document : texte imprimé Auteurs : Mónica J. B. Amorim ; Yannick Gansemans ; Susana I. L. Gomes ; et al. Année de publication : 2021 Article en page(s) : p. 8-19 Langues : Anglais (eng) Résumé : Enchytraeids (Annelida) are soil invertebrates with worldwide distribution that have served as ecotoxicology models for over 20 years. We present the first high-quality reference genome of Enchytraeus crypticus, assembled from a combination of Pacific Bioscience single-molecule real-time and Illumina sequencing platforms as a 525.2 Mbp genome (910 gapless scaffolds and 18,452 genes). We highlight isopenicillin, acquired by horizontal gene transfer and conferring antibiotic function. Significant gene family expansions associated with regeneration (long interspersed nuclear elements), the innate immune system (tripartite motif-containing protein) and response to stress (cytochrome P450) were identified. The ACE (Angiotensin-converting enzyme) — a homolog of ACE2, which is involved in the coronavirus SARS-CoV-2 cell entry — is also present in E. crypticus. There is an obvious potential of using E. crypticus as a model to study interactions between regeneration, the innate immune system and aging-dependent decline. En ligne : https://www.nature.com/articles/s41684-021-00831-x Permalink : ./index.php?lvl=notice_display&id=98138 [article] Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system [texte imprimé] / Mónica J. B. Amorim ; Yannick Gansemans ; Susana I. L. Gomes ; et al. . - 2021 . - p. 8-19. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°11 (November 2021) . - p. 8-19 Résumé : Enchytraeids (Annelida) are soil invertebrates with worldwide distribution that have served as ecotoxicology models for over 20 years. We present the first high-quality reference genome of Enchytraeus crypticus, assembled from a combination of Pacific Bioscience single-molecule real-time and Illumina sequencing platforms as a 525.2 Mbp genome (910 gapless scaffolds and 18,452 genes). We highlight isopenicillin, acquired by horizontal gene transfer and conferring antibiotic function. Significant gene family expansions associated with regeneration (long interspersed nuclear elements), the innate immune system (tripartite motif-containing protein) and response to stress (cytochrome P450) were identified. The ACE (Angiotensin-converting enzyme) — a homolog of ACE2, which is involved in the coronavirus SARS-CoV-2 cell entry — is also present in E. crypticus. There is an obvious potential of using E. crypticus as a model to study interactions between regeneration, the innate immune system and aging-dependent decline. En ligne : https://www.nature.com/articles/s41684-021-00831-x Permalink : ./index.php?lvl=notice_display&id=98138

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On the past, present, and future of in vivo science / Ellen P. Neff in LabAnimal, Vol. 21 N°11 (November 2021)

Public ISBD [article]  inLabAnimal > Vol. 21 N°11 (November 2021) . - p. 23-27 Titre : On the past, present, and future of in vivo science Type de document : texte imprimé Auteurs : Ellen P. Neff Année de publication : 2021 Article en page(s) : p. 23-27 Langues : Anglais (eng) Résumé : Lab Animal asked a group of experts in industry and academia about how the field has changed over their careers and how they think animal research can be improved in the future. Permalink : ./index.php?lvl=notice_display&id=98139 [article] On the past, present, and future of in vivo science [texte imprimé] / Ellen P. Neff . - 2021 . - p. 23-27. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°11 (November 2021) . - p. 23-27 Résumé : Lab Animal asked a group of experts in industry and academia about how the field has changed over their careers and how they think animal research can be improved in the future. Permalink : ./index.php?lvl=notice_display&id=98139

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Know Your Model: A brief history of making mutant mouse genetic models / Susan M. Bello in LabAnimal, Vol. 21 N°11 (November 2021)

Public ISBD [article]  inLabAnimal > Vol. 21 N°11 (November 2021) . - p. 31-34 Titre : Know Your Model: A brief history of making mutant mouse genetic models Type de document : texte imprimé Auteurs : Susan M. Bello ; Michelle N. Perry ; Cynthia L. Smith Année de publication : 2021 Article en page(s) : p. 31-34 Langues : Anglais (eng) Mots-clés : Animals  Mice  Models, Genetic* Résumé : For over a century, researchers have used mice as models and adapted many new methods to create novel mutations in them. In the past 100+ years, we have gone from breeding strains for selected traits to inducing random mutations throughout the genome to creating designer alleles with multiple functions. Each method offers opportunities and challenges for researchers as they try to address specific research questions with mouse models. Permalink : ./index.php?lvl=notice_display&id=98140 [article] Know Your Model: A brief history of making mutant mouse genetic models [texte imprimé] / Susan M. Bello ; Michelle N. Perry ; Cynthia L. Smith . - 2021 . - p. 31-34. Langues : Anglais (eng) in LabAnimal > Vol. 21 N°11 (November 2021) . - p. 31-34 Mots-clés : Animals  Mice  Models, Genetic* Résumé : For over a century, researchers have used mice as models and adapted many new methods to create novel mutations in them. In the past 100+ years, we have gone from breeding strains for selected traits to inducing random mutations throughout the genome to creating designer alleles with multiple functions. Each method offers opportunities and challenges for researchers as they try to address specific research questions with mouse models. Permalink : ./index.php?lvl=notice_display&id=98140

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