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Réouverture dès ce lundi 19 août.
Lundi : 8h-18h30
Mardi : 8h-18h30
Mercredi 9h-16h30
Jeudi : 8h-18h30
Vendredi : 8h-16h30
Votre centre de documentation fermera de 12h30 à 13h ce vendredi 28 juin et fermera à 14h30.
Dès ce lundi 1er juillet jusqu'au mercredi 10 juillet l'horaire du centre de documentation sera adapté :
Lundi 1er juillet : de 8h à 12h et de 12h30 à 16h
Mardi 2 juillet : de 8h à 12h15
Mercredi 3 juillet : de 9h à 12h et de 12h30 à 15h15
Jeudi 4 juillet : de 8h à 12h30 et de 13h à 18h30
Lundi 8 juillet : de 8h à 12h et de 12h30 à 16h
Mardi 9 juillet : de 8h à 12h15
Réouverture dès ce lundi 19 août.
Bienvenue sur le catalogue du centre de documentation du campus de Montignies.
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Replacement of surgical vasectomy through the use of wild-type sterile hybrids / Chris Preece in LabAnimal, 03/21 (mars 2021)
[article]
Titre : Replacement of surgical vasectomy through the use of wild-type sterile hybrids Type de document : texte imprimé Auteurs : Chris Preece ; Samy Alghadban ; Amine Bouchareb ; et al. Année de publication : 2021 Article en page(s) : p. 9-15 Langues : Anglais (eng) Résumé : For the production and rederivation of mouse strains, pseudopregnant female mice are used for embryo transfer and serve as surrogate mothers to support embryo development to term. Vasectomized males are commonly used to render pseudopregnancy in females, generated by surgical procedures associated with considerable pain and discomfort. Genetically modified mouse strains with a sterility phenotype provide a non-surgical replacement and represent an important application of the 3Rs (Replacement, Reduction, Refinement). However, the maintenance of such genetically modified mouse strains requires extensive breeding and genotyping procedures, which are regulated procedures under national legislation. As an alternative, we have explored the use of sterile male hybrids that result when two wild-type mouse subspecies, Mus musculus musculus and Mus musculus domesticus, interbreed. We find the male STUSB6F1 hybrid, resulting from the mating of female STUS/Fore with male C57BL/6J, ideally suited and demonstrate that its performance for the production of oviduct and uterine transfer recipients is indistinguishable when compared to surgically vasectomized mice. The use of these sterile hybrids avoids the necessity for surgical procedures or the breeding of sterile genetically modified lines and can be generated by the simple mating of two wild-type laboratory strains—a non-regulated procedure. Furthermore, in contrast with the breeding of genetically sterile mice, all male offspring are sterile and suitable for the generation of pseudopregnancy, allowing their efficient production with minimal breeding pairs. Permalink : ./index.php?lvl=notice_display&id=92721
in LabAnimal > 03/21 (mars 2021) . - p. 9-15[article] Replacement of surgical vasectomy through the use of wild-type sterile hybrids [texte imprimé] / Chris Preece ; Samy Alghadban ; Amine Bouchareb ; et al. . - 2021 . - p. 9-15.
Langues : Anglais (eng)
in LabAnimal > 03/21 (mars 2021) . - p. 9-15
Résumé : For the production and rederivation of mouse strains, pseudopregnant female mice are used for embryo transfer and serve as surrogate mothers to support embryo development to term. Vasectomized males are commonly used to render pseudopregnancy in females, generated by surgical procedures associated with considerable pain and discomfort. Genetically modified mouse strains with a sterility phenotype provide a non-surgical replacement and represent an important application of the 3Rs (Replacement, Reduction, Refinement). However, the maintenance of such genetically modified mouse strains requires extensive breeding and genotyping procedures, which are regulated procedures under national legislation. As an alternative, we have explored the use of sterile male hybrids that result when two wild-type mouse subspecies, Mus musculus musculus and Mus musculus domesticus, interbreed. We find the male STUSB6F1 hybrid, resulting from the mating of female STUS/Fore with male C57BL/6J, ideally suited and demonstrate that its performance for the production of oviduct and uterine transfer recipients is indistinguishable when compared to surgically vasectomized mice. The use of these sterile hybrids avoids the necessity for surgical procedures or the breeding of sterile genetically modified lines and can be generated by the simple mating of two wild-type laboratory strains—a non-regulated procedure. Furthermore, in contrast with the breeding of genetically sterile mice, all male offspring are sterile and suitable for the generation of pseudopregnancy, allowing their efficient production with minimal breeding pairs. Permalink : ./index.php?lvl=notice_display&id=92721 Réservation
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[article]
Titre : Model matchmaking Type de document : texte imprimé Auteurs : Ellen P. Neff Année de publication : 2021 Article en page(s) : p. 16-20 Langues : Anglais (eng) Résumé : Building platforms to connect clinicians and model organism researchers.
What do a child with a heart defect and a fruit fly with notched wings have in common? The answer may not be obvious at a glance, but the aberrant phenotypes share genetic pathways1. But unlike a patient, that fly can be manipulated with an ever-growing number of genetic tools and tested with different assays to tease apart pathogenic mechanisms, while scores and scores of flies can be quickly dosed with potential therapeutics in attempts to rescue an anomalous phenotype. The same can increasingly be said of zebrafish, C. elegans worms, mice and frogs and other model organisms deployed in research labs around the world.En ligne : https://www.nature.com/articles/s41684-020-00706-7 Permalink : ./index.php?lvl=notice_display&id=92722
in LabAnimal > 03/21 (mars 2021) . - p. 16-20[article] Model matchmaking [texte imprimé] / Ellen P. Neff . - 2021 . - p. 16-20.
Langues : Anglais (eng)
in LabAnimal > 03/21 (mars 2021) . - p. 16-20
Résumé : Building platforms to connect clinicians and model organism researchers.
What do a child with a heart defect and a fruit fly with notched wings have in common? The answer may not be obvious at a glance, but the aberrant phenotypes share genetic pathways1. But unlike a patient, that fly can be manipulated with an ever-growing number of genetic tools and tested with different assays to tease apart pathogenic mechanisms, while scores and scores of flies can be quickly dosed with potential therapeutics in attempts to rescue an anomalous phenotype. The same can increasingly be said of zebrafish, C. elegans worms, mice and frogs and other model organisms deployed in research labs around the world.En ligne : https://www.nature.com/articles/s41684-020-00706-7 Permalink : ./index.php?lvl=notice_display&id=92722 Réservation
Réserver ce document
Exemplaires (1)
Cote Support Localisation Section Disponibilité Revue Revue Centre de Documentation HELHa Campus Montignies Armoires à volets Disponible
Disponible