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Development of a new preclinical model of Parkinson’s disease / Alexandra Le Bras in LabAnimal, 9/2020 (Septembre 2020)  

Public ISBD [article]  inLabAnimal > 9/2020 (Septembre 2020) . - p. 4 Titre : Development of a new preclinical model of Parkinson’s disease Type de document : texte imprimé Auteurs : Alexandra Le Bras Année de publication : 2020 Article en page(s) : p. 4 Langues : Anglais (eng) Résumé : Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra and subsequent reduction of dopamine levels in the striatum, which results in motor impairment. Stem cell transplantation strategies aimed at replacing lost dopamine neurons have shown promising results in preclinical studies, but most of these studies have used toxin-induced models of PD, such as the 6-hydroxydopamine (6-OHDA) rodent model, which do not fully recapitulate human disease and might not predict the long-term effects of the host environment on the transplanted cells. En ligne : https://www.nature.com/articles/s41684-020-0612-3 Permalink : ./index.php?lvl=notice_display&id=90770 [article] Development of a new preclinical model of Parkinson’s disease [texte imprimé] / Alexandra Le Bras . - 2020 . - p. 4. Langues : Anglais (eng) in LabAnimal > 9/2020 (Septembre 2020) . - p. 4 Résumé : Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra and subsequent reduction of dopamine levels in the striatum, which results in motor impairment. Stem cell transplantation strategies aimed at replacing lost dopamine neurons have shown promising results in preclinical studies, but most of these studies have used toxin-induced models of PD, such as the 6-hydroxydopamine (6-OHDA) rodent model, which do not fully recapitulate human disease and might not predict the long-term effects of the host environment on the transplanted cells. En ligne : https://www.nature.com/articles/s41684-020-0612-3 Permalink : ./index.php?lvl=notice_display&id=90770

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CRISPR for choanoflagellates expands the genetic toolbox for our sister group / Ellen P. Neff in LabAnimal, 9/2020 (Septembre 2020)  

Public ISBD [article]  inLabAnimal > 9/2020 (Septembre 2020) . - p. 8 Titre : CRISPR for choanoflagellates expands the genetic toolbox for our sister group Type de document : texte imprimé Auteurs : Ellen P. Neff Année de publication : 2020 Article en page(s) : p. 8 Langues : Anglais (eng) Résumé : Throughout the waters of world, from the tropics to the poles and from salty seas to freshwater ponds, you’ll find curious eukaryotes called choanoflagellates. Some live freely as single cells while others will form multicellular colonies in various shapes and configurations. They can be mobile, propelled through their watery habitats in a sperm-like manner by flagella, or found attached to different substrates in their environment. En ligne : https://www.nature.com/articles/s41684-020-0613-2 Permalink : ./index.php?lvl=notice_display&id=90772 [article] CRISPR for choanoflagellates expands the genetic toolbox for our sister group [texte imprimé] / Ellen P. Neff . - 2020 . - p. 8. Langues : Anglais (eng) in LabAnimal > 9/2020 (Septembre 2020) . - p. 8 Résumé : Throughout the waters of world, from the tropics to the poles and from salty seas to freshwater ponds, you’ll find curious eukaryotes called choanoflagellates. Some live freely as single cells while others will form multicellular colonies in various shapes and configurations. They can be mobile, propelled through their watery habitats in a sperm-like manner by flagella, or found attached to different substrates in their environment. En ligne : https://www.nature.com/articles/s41684-020-0613-2 Permalink : ./index.php?lvl=notice_display&id=90772

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Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics / Chibueze D. Nwagwu in LabAnimal, 9/2020 (Septembre 2020)  

Public ISBD [article]  inLabAnimal > 9/2020 (Septembre 2020) . - p. 12-20 Titre : Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics Type de document : texte imprimé Auteurs : Chibueze D. Nwagwu ; Erwin Defensor ; Michael Y. Jiang ; et al. Année de publication : 2020 Article en page(s) : p. 12-20 Langues : Anglais (eng) En ligne : https://www.nature.com/articles/s41684-020-0594-1 Permalink : ./index.php?lvl=notice_display&id=90773 [article] Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics [texte imprimé] / Chibueze D. Nwagwu ; Erwin Defensor ; Michael Y. Jiang ; et al. . - 2020 . - p. 12-20. Langues : Anglais (eng) in LabAnimal > 9/2020 (Septembre 2020) . - p. 12-20 En ligne : https://www.nature.com/articles/s41684-020-0594-1 Permalink : ./index.php?lvl=notice_display&id=90773

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Some animal models are more equal than others: Cortico-striatal circuits for translation / Megan M. Monko in LabAnimal, 9/2020 (Septembre 2020)  

Public ISBD [article]  inLabAnimal > 9/2020 (Septembre 2020) . - p. 24-26 Titre : Some animal models are more equal than others: Cortico-striatal circuits for translation Type de document : texte imprimé Auteurs : Megan M. Monko ; Sarah R. Heilbronner Année de publication : 2020 Article en page(s) : p. 24-26 Langues : Anglais (eng) Résumé : Cortico-striatal circuits are at the heart of many brain disorders, which means they are often studied using neurobiological animal models. A new study uses resting-state functional connectivity to assess homologies of cortico-striatal circuits in mice, monkeys, and humans. En ligne : https://www.nature.com/articles/s41684-020-0601-6 Permalink : ./index.php?lvl=notice_display&id=90774 [article] Some animal models are more equal than others: Cortico-striatal circuits for translation [texte imprimé] / Megan M. Monko ; Sarah R. Heilbronner . - 2020 . - p. 24-26. Langues : Anglais (eng) in LabAnimal > 9/2020 (Septembre 2020) . - p. 24-26 Résumé : Cortico-striatal circuits are at the heart of many brain disorders, which means they are often studied using neurobiological animal models. A new study uses resting-state functional connectivity to assess homologies of cortico-striatal circuits in mice, monkeys, and humans. En ligne : https://www.nature.com/articles/s41684-020-0601-6 Permalink : ./index.php?lvl=notice_display&id=90774

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Following the fate of cells in vivo / Jim Kling in LabAnimal, 9/2020 (Septembre 2020)  

Public ISBD [article]  inLabAnimal > 9/2020 (Septembre 2020) . - p. 28-31 Titre : Following the fate of cells in vivo Type de document : texte imprimé Auteurs : Jim Kling Année de publication : 2020 Article en page(s) : p. 28-31 Langues : Anglais (eng) Résumé : Researchers are building better barcodes and combining spatial and temporal tools to trace cell lineages from the earliest stages of animal development—and beyond. En ligne : https://www.nature.com/articles/s41684-020-0602-5 Permalink : ./index.php?lvl=notice_display&id=90775 [article] Following the fate of cells in vivo [texte imprimé] / Jim Kling . - 2020 . - p. 28-31. Langues : Anglais (eng) in LabAnimal > 9/2020 (Septembre 2020) . - p. 28-31 Résumé : Researchers are building better barcodes and combining spatial and temporal tools to trace cell lineages from the earliest stages of animal development—and beyond. En ligne : https://www.nature.com/articles/s41684-020-0602-5 Permalink : ./index.php?lvl=notice_display&id=90775

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