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High-throughput tech puts worms on repeat Mention de date : août 2019
Paru le : 01/08/2019
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[article]
Titre : |
Outrunning Salmonella – the role of endogenous Enterobacteriaceae in variable colonization resistance |
Type de document : |
texte imprimé |
Auteurs : |
Siegfried Hapfelmeier |
Année de publication : |
2019 |
Article en page(s) : |
p. 15-16 |
Langues : |
Anglais (eng) |
Résumé : |
The mammalian gut microbiota confers colonization resistance against pathogenic bacteria. Specific pathogen-free C57BL/6 mice from different vendors are variably resistant to oral non-typhoidal Salmonella infection. New work shows that differences in endogenous Enterobacteriaceae determine this phenotypic variability. |
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in LabAnimal > 08/19 (août 2019) . - p. 15-16
[article] Outrunning Salmonella – the role of endogenous Enterobacteriaceae in variable colonization resistance [texte imprimé] / Siegfried Hapfelmeier . - 2019 . - p. 15-16. Langues : Anglais ( eng) in LabAnimal > 08/19 (août 2019) . - p. 15-16
Résumé : |
The mammalian gut microbiota confers colonization resistance against pathogenic bacteria. Specific pathogen-free C57BL/6 mice from different vendors are variably resistant to oral non-typhoidal Salmonella infection. New work shows that differences in endogenous Enterobacteriaceae determine this phenotypic variability. |
Permalink : |
./index.php?lvl=notice_display&id=80088 |
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[article]
Titre : |
Digging deeper: methodologies for high-content phenotyping in Caenorhabditis elegans |
Type de document : |
texte imprimé |
Auteurs : |
Dhaval S. Patel ; Nan Xu ; Hang Lu |
Année de publication : |
2019 |
Article en page(s) : |
p. 17-27 |
Langues : |
Anglais (eng) |
Résumé : |
Deep phenotyping is an emerging conceptual paradigm and experimental approach aimed at measuring and linking many aspects of a phenotype to understand its underlying biology. To date, deep phenotyping has been applied mostly in cultured cells and used less in multicellular organisms. However, in the past decade, it has increasingly been recognized that deep phenotyping could lead to a better understanding of how genetics, environment and stochasticity affect the development, physiology and behavior of an organism. The nematode Caenorhabditis elegans is an invaluable model system for studying how genes affect a phenotypic trait, and new technologies have taken advantage of the worm’s physical attributes to increase the throughput and informational content of experiments. Coupling of these technical advancements with computational and analytical tools has enabled a boom in deep-phenotyping studies of C. elegans. In this Review, we highlight how these new technologies and tools are digging into the biological origins of complex, multidimensional phenotypes. |
Permalink : |
./index.php?lvl=notice_display&id=80089 |
in LabAnimal > 08/19 (août 2019) . - p. 17-27
[article] Digging deeper: methodologies for high-content phenotyping in Caenorhabditis elegans [texte imprimé] / Dhaval S. Patel ; Nan Xu ; Hang Lu . - 2019 . - p. 17-27. Langues : Anglais ( eng) in LabAnimal > 08/19 (août 2019) . - p. 17-27
Résumé : |
Deep phenotyping is an emerging conceptual paradigm and experimental approach aimed at measuring and linking many aspects of a phenotype to understand its underlying biology. To date, deep phenotyping has been applied mostly in cultured cells and used less in multicellular organisms. However, in the past decade, it has increasingly been recognized that deep phenotyping could lead to a better understanding of how genetics, environment and stochasticity affect the development, physiology and behavior of an organism. The nematode Caenorhabditis elegans is an invaluable model system for studying how genes affect a phenotypic trait, and new technologies have taken advantage of the worm’s physical attributes to increase the throughput and informational content of experiments. Coupling of these technical advancements with computational and analytical tools has enabled a boom in deep-phenotyping studies of C. elegans. In this Review, we highlight how these new technologies and tools are digging into the biological origins of complex, multidimensional phenotypes. |
Permalink : |
./index.php?lvl=notice_display&id=80089 |
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Revue | Revue | Centre de Documentation HELHa Campus Montignies | Armoires à volets | Disponible Disponible |
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Revue | Revue | Centre de Documentation HELHa Campus Montignies | Armoires à volets | Disponible Disponible |