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Dès ce lundi 1er juillet jusqu'au mercredi 10 juillet l'horaire du centre de documentation sera adapté :
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Mercredi 3 juillet : de 9h à 12h et de 12h30 à 15h15
Jeudi 4 juillet : de 8h à 12h30 et de 13h à 18h30
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LabAnimal . 7/19Mention de date : juillet 2019 Paru le : 01/07/2019 |
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Ajouter le résultat dans votre panierFarewell, FATZO: a NASH mouse update / Ellen P. Neff in LabAnimal, 7/19 (juillet 2019)
[article]
Titre : Farewell, FATZO: a NASH mouse update Type de document : texte imprimé Auteurs : Ellen P. Neff Année de publication : 2019 Article en page(s) : p. 10 Langues : Anglais (eng) Permalink : ./index.php?lvl=notice_display&id=80084
in LabAnimal > 7/19 (juillet 2019) . - p. 10[article] Farewell, FATZO: a NASH mouse update [texte imprimé] / Ellen P. Neff . - 2019 . - p. 10.
Langues : Anglais (eng)
in LabAnimal > 7/19 (juillet 2019) . - p. 10
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Titre : Animal behavior on auto Type de document : texte imprimé Auteurs : Ellen P. Neff Année de publication : 2019 Article en page(s) : p. 12-16 Langues : Anglais (eng) Résumé : Researchers can’t sit their laboratory mice or fruit flies down and ask them how they’re feeling or why they’re behaving in a particular way. Instead, humans are left to observe and interpret the various clues their animals provide. Can machines help? En ligne : https://www.nature.com/articles/s41684-019-0312-z Permalink : ./index.php?lvl=notice_display&id=80085
in LabAnimal > 7/19 (juillet 2019) . - p. 12-16[article] Animal behavior on auto [texte imprimé] / Ellen P. Neff . - 2019 . - p. 12-16.
Langues : Anglais (eng)
in LabAnimal > 7/19 (juillet 2019) . - p. 12-16
Résumé : Researchers can’t sit their laboratory mice or fruit flies down and ask them how they’re feeling or why they’re behaving in a particular way. Instead, humans are left to observe and interpret the various clues their animals provide. Can machines help? En ligne : https://www.nature.com/articles/s41684-019-0312-z Permalink : ./index.php?lvl=notice_display&id=80085 Réservation
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DisponibleExperiments done in Black-6 mice: what does it mean? / Johanna Åhlgren in LabAnimal, 7/19 (juillet 2019)
[article]
Titre : Experiments done in Black-6 mice: what does it mean? Type de document : texte imprimé Auteurs : Johanna Åhlgren ; Vootele Voikar Année de publication : 2019 Article en page(s) : p. 17-28 Langues : Anglais (eng) Résumé : Low replicability of animal experiments is perceived as a major hurdle in the field of biomedicine. Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to use isogenic mice. The C57BL/6 strain has evolved as a gold standard strain for this purpose. However, C57BL/6 mice are maintained as substrains by multiple vendors. Evidence exists that the subtle differences between these mouse lines have not been systematically investigated and are often ignored. In the present study, we characterized the female mice of two closely related substrains (C57BL/6J and C57BL/6N) from three vendors in Europe (Charles River Laboratories, Envigo, Janvier Labs) in a battery of behavioral tests. Our data show and confirm substantial behavioral differences between the C57BL/6J and C57BL/6N mice. Importantly, the substrain differences were largely affected by the origin of the animals, as a significant effect of vendor or interaction between the substrain and vendor occurred in all tests. This work highlights the importance of adhering to precise international nomenclature in all publications reporting animal experiments. Moreover, the generalization of research findings from a single mouse substrain can be seriously limited due to genetic drift and environmental variables occurring at different vendors. However, heterogenization of samples, by including animals of different substrains, can enhance generalizability. These issues need to be seriously addressed to improve reproducibility, replicability, and the translational potential of the mouse models. Permalink : ./index.php?lvl=notice_display&id=80086
in LabAnimal > 7/19 (juillet 2019) . - p. 17-28[article] Experiments done in Black-6 mice: what does it mean? [texte imprimé] / Johanna Åhlgren ; Vootele Voikar . - 2019 . - p. 17-28.
Langues : Anglais (eng)
in LabAnimal > 7/19 (juillet 2019) . - p. 17-28
Résumé : Low replicability of animal experiments is perceived as a major hurdle in the field of biomedicine. Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to use isogenic mice. The C57BL/6 strain has evolved as a gold standard strain for this purpose. However, C57BL/6 mice are maintained as substrains by multiple vendors. Evidence exists that the subtle differences between these mouse lines have not been systematically investigated and are often ignored. In the present study, we characterized the female mice of two closely related substrains (C57BL/6J and C57BL/6N) from three vendors in Europe (Charles River Laboratories, Envigo, Janvier Labs) in a battery of behavioral tests. Our data show and confirm substantial behavioral differences between the C57BL/6J and C57BL/6N mice. Importantly, the substrain differences were largely affected by the origin of the animals, as a significant effect of vendor or interaction between the substrain and vendor occurred in all tests. This work highlights the importance of adhering to precise international nomenclature in all publications reporting animal experiments. Moreover, the generalization of research findings from a single mouse substrain can be seriously limited due to genetic drift and environmental variables occurring at different vendors. However, heterogenization of samples, by including animals of different substrains, can enhance generalizability. These issues need to be seriously addressed to improve reproducibility, replicability, and the translational potential of the mouse models. Permalink : ./index.php?lvl=notice_display&id=80086 Réservation
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