Dépouillements

Toxicology testing steps towards computers / Jim Kling in LabAnimal, 3/19 (mars 2019)  

Public ISBD [article]  inLabAnimal > 3/19 (mars 2019) . - p. 11-13 Titre : Toxicology testing steps towards computers Type de document : texte imprimé Auteurs : Jim Kling Année de publication : 2019 Article en page(s) : p. 11-13 Langues : Anglais (eng) Résumé : Can the computer eliminate the lab animal? As computational methods become more advanced and data more freely available, in silico modeling approaches have growing potential to help reduce the number of animals needed to test chemical toxicity. En ligne : https://www.nature.com/articles/s41684-018-0227-0 Permalink : ./index.php?lvl=notice_display&id=80066 [article] Toxicology testing steps towards computers [texte imprimé] / Jim Kling . - 2019 . - p. 11-13. Langues : Anglais (eng) in LabAnimal > 3/19 (mars 2019) . - p. 11-13 Résumé : Can the computer eliminate the lab animal? As computational methods become more advanced and data more freely available, in silico modeling approaches have growing potential to help reduce the number of animals needed to test chemical toxicity. En ligne : https://www.nature.com/articles/s41684-018-0227-0 Permalink : ./index.php?lvl=notice_display&id=80066

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

Nonhuman primate species as models of human bacterial sepsis / Lingye Chen in LabAnimal, 3/19 (mars 2019)

Public ISBD [article]  inLabAnimal > 3/19 (mars 2019) . - p. 14-27 Titre : Nonhuman primate species as models of human bacterial sepsis Type de document : texte imprimé Auteurs : Lingye Chen ; Karen E. Welty-Wolf ; Bryan D. Kraft Année de publication : 2019 Article en page(s) : p. 14-27 Langues : Anglais (eng) Résumé : Sepsis involves a disordered host response to systemic infection leading to high morbidity and mortality. Despite intense research, targeted sepsis therapies beyond antibiotics have remained elusive. The cornerstone of sepsis research is the development of animal models to mimic human bacterial infections and test novel pharmacologic targets. Nonhuman primates (NHPs) have served as an attractive, but expensive, animal to model human bacterial infections due to their nearly identical cardiopulmonary anatomy and physiology, as well as host response to infection. Several NHP species have provided substantial insight into sepsis-mediated inflammation, endothelial dysfunction, acute lung injury, and multi-organ failure. The use of NHPs has usually focused on translating therapies from early preclinical models to human clinical trials. However, despite successful sepsis interventions in NHP models, there are still no FDA-approved sepsis therapies. This review highlights major NHP models of bacterial sepsis and their relevance to clinical medicine. Permalink : ./index.php?lvl=notice_display&id=80068 [article] Nonhuman primate species as models of human bacterial sepsis [texte imprimé] / Lingye Chen ; Karen E. Welty-Wolf ; Bryan D. Kraft . - 2019 . - p. 14-27. Langues : Anglais (eng) in LabAnimal > 3/19 (mars 2019) . - p. 14-27 Résumé : Sepsis involves a disordered host response to systemic infection leading to high morbidity and mortality. Despite intense research, targeted sepsis therapies beyond antibiotics have remained elusive. The cornerstone of sepsis research is the development of animal models to mimic human bacterial infections and test novel pharmacologic targets. Nonhuman primates (NHPs) have served as an attractive, but expensive, animal to model human bacterial infections due to their nearly identical cardiopulmonary anatomy and physiology, as well as host response to infection. Several NHP species have provided substantial insight into sepsis-mediated inflammation, endothelial dysfunction, acute lung injury, and multi-organ failure. The use of NHPs has usually focused on translating therapies from early preclinical models to human clinical trials. However, despite successful sepsis interventions in NHP models, there are still no FDA-approved sepsis therapies. This review highlights major NHP models of bacterial sepsis and their relevance to clinical medicine. Permalink : ./index.php?lvl=notice_display&id=80068

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

Who's responsible for the llama drama ? in LabAnimal, 3/19 (mars 2019)

Public ISBD [article]  inLabAnimal > 3/19 (mars 2019) . - p. 28-31 Titre : Who's responsible for the llama drama ? Type de document : texte imprimé Année de publication : 2019 Article en page(s) : p. 28-31 Langues : Anglais (eng) Permalink : ./index.php?lvl=notice_display&id=80069 [article] Who's responsible for the llama drama ? [texte imprimé] . - 2019 . - p. 28-31. Langues : Anglais (eng) in LabAnimal > 3/19 (mars 2019) . - p. 28-31 Permalink : ./index.php?lvl=notice_display&id=80069

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible