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Is maternal microbial metabolism an early-life determinant of health? / Kymberleigh A. Romano in LabAnimal, 10/18 (Octobre 2018)

Public ISBD [article]  inLabAnimal > 10/18 (Octobre 2018) . - p. 10-15 Titre : Is maternal microbial metabolism an early-life determinant of health? Type de document : texte imprimé Auteurs : Kymberleigh A. Romano ; Federico E. Rey Année de publication : 2018 Article en page(s) : p. 10-15 Langues : Anglais (eng) Résumé : Mounting evidence suggests that environmental stress experienced in utero (for example, maternal nutritional deficits) establishes a predisposition in the newborn to the development of chronic diseases later in life. This concept is often referred to as the "fetal origins hypothesis" or "developmental origins of health and disease". Since its first proposal, epigenetics has emerged as an underlying mechanism explaining how environmental cues become gestationally "encoded". Many of the enzymes that impart and maintain epigenetic modifications are highly sensitive to nutrient availability, which can be influenced by the metabolic activities of the intestinal microbiota. Therefore, the maternal microbiome has the potential to influence epigenetics in utero and modulate offspring's long-term health trajectories. Here we summarize the current understanding of the interactions that occur between the maternal gut microbiome and the essential nutrient choline, that is not only required for fetal development and epigenetic regulation but is also a growth substrate for some microbes. Bacteria able to metabolize choline benefit from the presence of this nutrient and compete with the host for its access, which under extreme conditions may elicit signatures of choline deficiency. Another consequence of bacterial choline metabolism is the accumulation of the pro-inflammatory, pro-thrombotic metabolite trimethylamine-N-oxide (TMAO). Finally, we discuss how these different facets of microbial choline metabolism may influence infant development and health trajectories via epigenetic mechanisms and more broadly place a call to action to better understand how maternal microbial metabolism can shape their offspring's propensity to chronic disease development later in life. Permalink : ./index.php?lvl=notice_display&id=77324 [article] Is maternal microbial metabolism an early-life determinant of health? [texte imprimé] / Kymberleigh A. Romano ; Federico E. Rey . - 2018 . - p. 10-15. Langues : Anglais (eng) in LabAnimal > 10/18 (Octobre 2018) . - p. 10-15 Résumé : Mounting evidence suggests that environmental stress experienced in utero (for example, maternal nutritional deficits) establishes a predisposition in the newborn to the development of chronic diseases later in life. This concept is often referred to as the "fetal origins hypothesis" or "developmental origins of health and disease". Since its first proposal, epigenetics has emerged as an underlying mechanism explaining how environmental cues become gestationally "encoded". Many of the enzymes that impart and maintain epigenetic modifications are highly sensitive to nutrient availability, which can be influenced by the metabolic activities of the intestinal microbiota. Therefore, the maternal microbiome has the potential to influence epigenetics in utero and modulate offspring's long-term health trajectories. Here we summarize the current understanding of the interactions that occur between the maternal gut microbiome and the essential nutrient choline, that is not only required for fetal development and epigenetic regulation but is also a growth substrate for some microbes. Bacteria able to metabolize choline benefit from the presence of this nutrient and compete with the host for its access, which under extreme conditions may elicit signatures of choline deficiency. Another consequence of bacterial choline metabolism is the accumulation of the pro-inflammatory, pro-thrombotic metabolite trimethylamine-N-oxide (TMAO). Finally, we discuss how these different facets of microbial choline metabolism may influence infant development and health trajectories via epigenetic mechanisms and more broadly place a call to action to better understand how maternal microbial metabolism can shape their offspring's propensity to chronic disease development later in life. Permalink : ./index.php?lvl=notice_display&id=77324

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What is a lab animal? / Ellen P. Neff in LabAnimal, 10/18 (Octobre 2018)  

Public ISBD [article]  inLabAnimal > 10/18 (Octobre 2018) . - p. 19-23 Titre : What is a lab animal? Type de document : texte imprimé Auteurs : Ellen P. Neff Année de publication : 2018 Article en page(s) : p. 19-23 Langues : Anglais (eng) Résumé : Small but dedicated communities are bringing the earliest lineages of the animal kingdom into the lab. Take a look at the ctenophores, the sponges, and the placozoans. En ligne : https://www.nature.com/articles/s41684-018-0135-3 Permalink : ./index.php?lvl=notice_display&id=77325 [article] What is a lab animal? [texte imprimé] / Ellen P. Neff . - 2018 . - p. 19-23. Langues : Anglais (eng) in LabAnimal > 10/18 (Octobre 2018) . - p. 19-23 Résumé : Small but dedicated communities are bringing the earliest lineages of the animal kingdom into the lab. Take a look at the ctenophores, the sponges, and the placozoans. En ligne : https://www.nature.com/articles/s41684-018-0135-3 Permalink : ./index.php?lvl=notice_display&id=77325

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