Dépouillements

Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. / Joanna E. Fishback in LabAnimal-Europe, 03/16 (mars 2016)

Public ISBD [article]  inLabAnimal-Europe > 03/16 (mars 2016) . - p. 10-14 Titre : Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Type de document : texte imprimé Auteurs : Joanna E. Fishback Année de publication : 2016 Article en page(s) : p. 10-14 Langues : Anglais (eng) Mots-clés : Adjuvants, Immunologic/administration & dosage  Adjuvants, Immunologic/pharmacology  Animals  Anti-Inflammatory Agents, Non-Steroidal/administration & dosage Anti-Inflammatory  Agents, Non-Steroidal/pharmacology*  Antibody Formation/drug effects  Carbazoles/administration & dosage  Carbazoles/pharmacology*  Drug Therapy, Combination  Female  Freund's Adjuvant/administration & dosage  Freund's Adjuvant/pharmacology*  Rabbits/immunology*  Adjuvants, Immunologic  Anti-Inflammatory Agents, Non-Steroidal  Carbazoles  Freund's Adjuvant  carprofen Résumé : Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA. Note de contenu : Erratum in Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Permalink : ./index.php?lvl=notice_display&id=76492 [article] Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. [texte imprimé] / Joanna E. Fishback . - 2016 . - p. 10-14. Langues : Anglais (eng) in LabAnimal-Europe > 03/16 (mars 2016) . - p. 10-14 Mots-clés : Adjuvants, Immunologic/administration & dosage  Adjuvants, Immunologic/pharmacology  Animals  Anti-Inflammatory Agents, Non-Steroidal/administration & dosage Anti-Inflammatory  Agents, Non-Steroidal/pharmacology*  Antibody Formation/drug effects  Carbazoles/administration & dosage  Carbazoles/pharmacology*  Drug Therapy, Combination  Female  Freund's Adjuvant/administration & dosage  Freund's Adjuvant/pharmacology*  Rabbits/immunology*  Adjuvants, Immunologic  Anti-Inflammatory Agents, Non-Steroidal  Carbazoles  Freund's Adjuvant  carprofen Résumé : Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA. Note de contenu : Erratum in Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Permalink : ./index.php?lvl=notice_display&id=76492

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

Common swine models of cardiovascular disease for research and training / Veronica Crisóstomo in LabAnimal-Europe, 03/16 (mars 2016)

Public ISBD [article]  inLabAnimal-Europe > 03/16 (mars 2016) . - p. 16-28 Titre : Common swine models of cardiovascular disease for research and training Type de document : texte imprimé Auteurs : Veronica Crisóstomo Année de publication : 2016 Article en page(s) : p. 16-28 Langues : Anglais (eng) Mots-clés : Animals  Biomedical Research/education  Cardiovascular Diseases/diagnosis*  Cardiovascular Diseases/etiology  Cardiovascular Diseases/therapy*  Disease Models, Animal  Sus scrofa* Résumé : Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems. Permalink : ./index.php?lvl=notice_display&id=76493 [article] Common swine models of cardiovascular disease for research and training [texte imprimé] / Veronica Crisóstomo . - 2016 . - p. 16-28. Langues : Anglais (eng) in LabAnimal-Europe > 03/16 (mars 2016) . - p. 16-28 Mots-clés : Animals  Biomedical Research/education  Cardiovascular Diseases/diagnosis*  Cardiovascular Diseases/etiology  Cardiovascular Diseases/therapy*  Disease Models, Animal  Sus scrofa* Résumé : Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems. Permalink : ./index.php?lvl=notice_display&id=76493

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible

Altered states part 2: addressing nausea in canine research subjects / Victoria Hampshire in LabAnimal-Europe, 03/16 (mars 2016)

Public ISBD [article]  inLabAnimal-Europe > 03/16 (mars 2016) . - p. 30-31 Titre : Altered states part 2: addressing nausea in canine research subjects Type de document : texte imprimé Auteurs : Victoria Hampshire Année de publication : 2016 Article en page(s) : p. 30-31 Langues : Anglais (eng) Mots-clés : Animals  Animals, Laboratory  Dogs/physiology*  Nausea/prevention & control*  Vomiting/prevention & control* Résumé : Nausea and emesis can occur for multiple reasons. While research staff can readily empathize with this type of discomfort, proper assessment and treatment can be challenging. In order to provide optimal care for canine research subjects, it is critical that institutions develop a treatment plan and take preemptive measures to control nausea and emesis when they occur. Permalink : ./index.php?lvl=notice_display&id=76494 [article] Altered states part 2: addressing nausea in canine research subjects [texte imprimé] / Victoria Hampshire . - 2016 . - p. 30-31. Langues : Anglais (eng) in LabAnimal-Europe > 03/16 (mars 2016) . - p. 30-31 Mots-clés : Animals  Animals, Laboratory  Dogs/physiology*  Nausea/prevention & control*  Vomiting/prevention & control* Résumé : Nausea and emesis can occur for multiple reasons. While research staff can readily empathize with this type of discomfort, proper assessment and treatment can be challenging. In order to provide optimal care for canine research subjects, it is critical that institutions develop a treatment plan and take preemptive measures to control nausea and emesis when they occur. Permalink : ./index.php?lvl=notice_display&id=76494

Réservation

Réserver ce document

Exemplaires (1)

Cote	Support	Localisation	Section	Disponibilité
Revue	Revue	Centre de Documentation HELHa Campus Montignies	Armoires à volets	Disponible Disponible