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Jeudi : 8h-18h30
Vendredi : 8h-16h30
Votre centre de documentation fermera de 12h30 à 13h ce vendredi 28 juin et fermera à 14h30.
Dès ce lundi 1er juillet jusqu'au mercredi 10 juillet l'horaire du centre de documentation sera adapté :
Lundi 1er juillet : de 8h à 12h et de 12h30 à 16h
Mardi 2 juillet : de 8h à 12h15
Mercredi 3 juillet : de 9h à 12h et de 12h30 à 15h15
Jeudi 4 juillet : de 8h à 12h30 et de 13h à 18h30
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Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. / Joanna E. Fishback in LabAnimal-Europe, 03/16 (mars 2016)
[article]
Titre : Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Type de document : texte imprimé Auteurs : Joanna E. Fishback Année de publication : 2016 Article en page(s) : p. 10-14 Langues : Anglais (eng) Mots-clés : Adjuvants, Immunologic/administration & dosage Adjuvants, Immunologic/pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal/administration & dosage Anti-Inflammatory Agents, Non-Steroidal/pharmacology* Antibody Formation/drug effects Carbazoles/administration & dosage Carbazoles/pharmacology* Drug Therapy, Combination Female Freund's Adjuvant/administration & dosage Freund's Adjuvant/pharmacology* Rabbits/immunology* Adjuvants, Immunologic Anti-Inflammatory Agents, Non-Steroidal Carbazoles Freund's Adjuvant carprofen Résumé : Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA. Note de contenu : Erratum in Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Permalink : ./index.php?lvl=notice_display&id=76492
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 10-14[article] Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. [texte imprimé] / Joanna E. Fishback . - 2016 . - p. 10-14.
Langues : Anglais (eng)
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 10-14
Mots-clés : Adjuvants, Immunologic/administration & dosage Adjuvants, Immunologic/pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal/administration & dosage Anti-Inflammatory Agents, Non-Steroidal/pharmacology* Antibody Formation/drug effects Carbazoles/administration & dosage Carbazoles/pharmacology* Drug Therapy, Combination Female Freund's Adjuvant/administration & dosage Freund's Adjuvant/pharmacology* Rabbits/immunology* Adjuvants, Immunologic Anti-Inflammatory Agents, Non-Steroidal Carbazoles Freund's Adjuvant carprofen Résumé : Freund's complete adjuvant (FCA) is a commonly used immunopotentiator that can boost polyclonal antibody production in animal models such as rabbits, but FCA is also known to cause inflammation and pain. It is important to balance the welfare of animals with the goal of efficiently producing antibodies, but little is known about how common treatments for pain and inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), affect the production of polyclonal antibodies. The purpose of this study was to measure polyclonal antibody production in rabbits that were administered FCA either with or without a concurrent treatment of a NSAID, carprofen. Rabbits were divided into two groups and were administered identical treatments of an antigen with adjuvant, and the treatment group also received carprofen injections at different stages of the study. Carprofen treatment did not significantly affect polyclonal antibody production, which suggests that carprofen and other NSAIDs can be used alongside FCA in rabbits to achieve desired levels of antibody production while minimizing pain and distress associated with the use of FCA. Note de contenu : Erratum in Erratum: Antibody production in rabbits administered Freund's complete adjuvant and carprofen concurrently. Permalink : ./index.php?lvl=notice_display&id=76492 Réservation
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DisponibleCommon swine models of cardiovascular disease for research and training / Veronica Crisóstomo in LabAnimal-Europe, 03/16 (mars 2016)
[article]
Titre : Common swine models of cardiovascular disease for research and training Type de document : texte imprimé Auteurs : Veronica Crisóstomo Année de publication : 2016 Article en page(s) : p. 16-28 Langues : Anglais (eng) Mots-clés : Animals Biomedical Research/education Cardiovascular Diseases/diagnosis* Cardiovascular Diseases/etiology Cardiovascular Diseases/therapy* Disease Models, Animal Sus scrofa* Résumé : Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems. Permalink : ./index.php?lvl=notice_display&id=76493
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 16-28[article] Common swine models of cardiovascular disease for research and training [texte imprimé] / Veronica Crisóstomo . - 2016 . - p. 16-28.
Langues : Anglais (eng)
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 16-28
Mots-clés : Animals Biomedical Research/education Cardiovascular Diseases/diagnosis* Cardiovascular Diseases/etiology Cardiovascular Diseases/therapy* Disease Models, Animal Sus scrofa* Résumé : Cardiovascular diseases are a major health concern and therefore an important topic in biomedical research. Large animal models allow researchers to assess the safety and efficacy of new cardiovascular procedures in systems that resemble human anatomy; additionally, they can be used to emulate scenarios for training purposes. Among the many biomedical models that are described in published literature, it is important that researchers understand and select those that are best suited to achieve the aims of their research, that facilitate the humane care and management of their research animals and that best promote the high ethical standards required of animal research. In this resource the authors describe some common swine models that can be easily incorporated into regular practices of research and training at biomedical institutions. These models use both native and altered vascular anatomy of swine to carry out research protocols, such as testing biological reactions to implanted materials, surgically creating aneurysms using autologous tissue and inducing myocardial infarction through closed-chest procedures. Such models can also be used for training, where native and altered vascular anatomy allow medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems. Permalink : ./index.php?lvl=notice_display&id=76493 Réservation
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DisponibleAltered states part 2: addressing nausea in canine research subjects / Victoria Hampshire in LabAnimal-Europe, 03/16 (mars 2016)
[article]
Titre : Altered states part 2: addressing nausea in canine research subjects Type de document : texte imprimé Auteurs : Victoria Hampshire Année de publication : 2016 Article en page(s) : p. 30-31 Langues : Anglais (eng) Mots-clés : Animals Animals, Laboratory Dogs/physiology* Nausea/prevention & control* Vomiting/prevention & control* Résumé : Nausea and emesis can occur for multiple reasons. While research staff can readily empathize with this type of discomfort, proper assessment and treatment can be challenging. In order to provide optimal care for canine research subjects, it is critical that institutions develop a treatment plan and take preemptive measures to control nausea and emesis when they occur. Permalink : ./index.php?lvl=notice_display&id=76494
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 30-31[article] Altered states part 2: addressing nausea in canine research subjects [texte imprimé] / Victoria Hampshire . - 2016 . - p. 30-31.
Langues : Anglais (eng)
in LabAnimal-Europe > 03/16 (mars 2016) . - p. 30-31
Mots-clés : Animals Animals, Laboratory Dogs/physiology* Nausea/prevention & control* Vomiting/prevention & control* Résumé : Nausea and emesis can occur for multiple reasons. While research staff can readily empathize with this type of discomfort, proper assessment and treatment can be challenging. In order to provide optimal care for canine research subjects, it is critical that institutions develop a treatment plan and take preemptive measures to control nausea and emesis when they occur. Permalink : ./index.php?lvl=notice_display&id=76494 Réservation
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