Centre de Documentation Campus Montignies
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Lundi : 8h-18h30
Mardi : 8h-17h30
Mercredi 9h-16h30
Jeudi : 8h30-18h30
Vendredi : 8h30-12h30 et 13h-14h30
Votre centre de documentation sera exceptionnellement fermé de 12h30 à 13h ce lundi 18 novembre.
Egalement, il sera fermé de 12h30 à 13h30 ce mercredi 20 novembre.
Bienvenue sur le catalogue du centre de documentation du campus de Montignies.
Mention de date : août 2017
Paru le : 01/08/2017
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[article] Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice [texte imprimé] / rachel A. Larsen . - 2017 . - p. 27-29. Langues : Anglais ( eng) in LabAnimal > 08/17 (août 2017) . - p. 27-29 |  |
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[article]
| Titre : |
Evaluation of the neutrophil:lymphocyte ratio as an indicator of chronic distress in the laboratory mouse |
| Type de document : |
texte imprimé |
| Auteurs : |
Debra L. Hickman |
| Année de publication : |
2017 |
| Article en page(s) : |
p. 16-23 |
| Langues : |
Anglais (eng) |
| Résumé : |
Abstract
When evaluating the effect of husbandry and biomethodologies on the well-being of laboratory mice, it is critical to utilize measurements that allow the distinguishing of acute stress from chronic stress. One of the most common measurements of stress in laboratory animals is the corticosterone assessment. However, while this measurement provides a highly accurate reflection of the animal's response to acute stressors, its interpretation is more prone to error when evaluating the effect of chronic stress. This study evaluated the use of the neutrophil:lymphocyte (NE:LY) ratio as an assessment of chronic stress in male and female C57Bl/6N mice as compared to serum corticosterone. One group of mice was exposed to mild daily stressors for 7 days, while the control group was handled with normal husbandry. The NE:LY ratio and serum corticosterone levels were significantly elevated in the chronically stressed mice, though a significant increase in corticosterone was only significant in males when compared by sex. The chronically stressed mice also demonstrated significantly fewer entries into the open arms and less time spent in the open arms of the elevated plus maze, suggesting that the mild daily stressors had induced a state of distress. The findings of this study confirm that the NE:LY ratio is a valid measurement for chronic stress in the laboratory mouse. However, these assays do not distinguish between distress or eustress, so behavioral and physiological assessments should always be included to determine a complete assessment of the well-being of the mouse. |
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in LabAnimal > 08/17 (août 2017) . - p. 16-23
[article] Evaluation of the neutrophil:lymphocyte ratio as an indicator of chronic distress in the laboratory mouse [texte imprimé] / Debra L. Hickman . - 2017 . - p. 16-23. Langues : Anglais ( eng) in LabAnimal > 08/17 (août 2017) . - p. 16-23
| Résumé : |
Abstract
When evaluating the effect of husbandry and biomethodologies on the well-being of laboratory mice, it is critical to utilize measurements that allow the distinguishing of acute stress from chronic stress. One of the most common measurements of stress in laboratory animals is the corticosterone assessment. However, while this measurement provides a highly accurate reflection of the animal's response to acute stressors, its interpretation is more prone to error when evaluating the effect of chronic stress. This study evaluated the use of the neutrophil:lymphocyte (NE:LY) ratio as an assessment of chronic stress in male and female C57Bl/6N mice as compared to serum corticosterone. One group of mice was exposed to mild daily stressors for 7 days, while the control group was handled with normal husbandry. The NE:LY ratio and serum corticosterone levels were significantly elevated in the chronically stressed mice, though a significant increase in corticosterone was only significant in males when compared by sex. The chronically stressed mice also demonstrated significantly fewer entries into the open arms and less time spent in the open arms of the elevated plus maze, suggesting that the mild daily stressors had induced a state of distress. The findings of this study confirm that the NE:LY ratio is a valid measurement for chronic stress in the laboratory mouse. However, these assays do not distinguish between distress or eustress, so behavioral and physiological assessments should always be included to determine a complete assessment of the well-being of the mouse. |
| Permalink : |
./index.php?lvl=notice_display&id=66484 |
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