[article] 
inLabAnimal > Vol.22 N°12 (décembre 2022) . - p. 21-22

Titre :	Expanded precision genome-editing toolbox for human disease modeling in zebrafish
Type de document :	texte imprimé
Auteurs :	Pratishtha Varshney ; Gaurav K. Varshney
Année de publication :	2022
Article en page(s) :	p. 21-22
Langues :	Anglais (eng)
Mots-clés :	biotechnologie  génétique
Résumé :	The application of genome-editing tools to generate point mutations in animal models is of particular value for precise disease modeling, but the PAM requirement of Cas enzymes is a critical limiting factor. Two new studies demonstrate that SpRY variant displays efficient genome editing in a nearly PAM-less manner in zebrafish, expanding the targeting scope of base editors in this model.
Permalink :	./index.php?lvl=notice_display&id=107929

[article] Expanded precision genome-editing toolbox for human disease modeling in zebrafish [texte imprimé] / Pratishtha Varshney ; Gaurav K. Varshney . - 2022 . - p. 21-22.
Langues : Anglais (eng)
in LabAnimal > Vol.22 N°12 (décembre 2022) . - p. 21-22

Mots-clés :	biotechnologie  génétique
Résumé :	The application of genome-editing tools to generate point mutations in animal models is of particular value for precise disease modeling, but the PAM requirement of Cas enzymes is a critical limiting factor. Two new studies demonstrate that SpRY variant displays efficient genome editing in a nearly PAM-less manner in zebrafish, expanding the targeting scope of base editors in this model.
Permalink :	./index.php?lvl=notice_display&id=107929